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Pentobarbital versus phenobarbital
Compare and Contrast of these two barbiturates
10
Pharmacology
Professional
12/03/2011
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Term
Pentobarbital
 Definition
Can be given rectally
Term
Pentobarbital and Phenobarbital
 Definition
Can be given oral, IV, and IM
Term
Pentobarbital
 Definition
Short acting (1-4 hours)
Term
Phenobarbital
 Definition
Long acting (days)
Term
Pentobarbital and Phenobarbital
 Definition
Increases efficacy of GABA by increasing open time of Cl channel
Term
Pentobarbital
 Definition
Direct GABA A receptor activation
Term
Pentobarbital and Phenobarbital
 Definition
Noncompetitive antagonist at AMPA receptor
Term
Pentobarbital
 Definition
Used for preoperative sedation
Term
Pentobarbital
 Definition
Emergency treatment for seizures
Term
Phenobarbital
 Definition
Anticonvulsant
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