Term
| What inc blood level of penicillins? |
|
Definition
| Probenicid - impairs renal tubular secretion of weak acids - inc blood level of penicilin |
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Term
|
Definition
| Silver nitrate (eye infection) or Ceftriaxone |
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Term
|
Definition
1) Pneumococcal Pneumonia (S. Pneumonia)
2)Syphilis
3) Gonorrhea |
|
|
Term
Beta-hemolytic strep pharyngitis
Syphilis |
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Definition
| Benzathine penicillin G (BPG) tx for what |
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|
Term
| mild to moderate staph infections |
|
Definition
| Oral OCD (oxacillin, cloxacillin, dicloxacillin) |
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Term
|
Definition
|
|
Term
| Penicillin resistant pneumococci tx |
|
Definition
| Amoxicillin and ampicillin |
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|
Term
| DOC for Listeria monocytogenes |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What is the spectrum for Amoxicilin and ampicillin? |
|
Definition
-Same as Penicillin G PLUS
-Gram (+) bacilli: Listeria monocytogenes
-Gram (-) rods: E. coli, H. influenza, Proteus mirabilis, Salmonella typhi |
|
|
Term
| tx for Pseudomonas aeruginosa |
|
Definition
| Ticarcillin and Piperacillin |
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|
Term
| tx for infections outside of the urinary tract |
|
Definition
| Ticarcillin/Piperacillin + Aminoglycosides/Fluoroquinolones |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Amoxicillin + Calvulanic acid |
|
Definition
|
|
Term
| Piperacillin + Taxobactam |
|
Definition
|
|
Term
| Hypersensitivity and Nephritis |
|
Definition
| main side effects of penicillins |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
|
Definition
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|
Term
|
Definition
|
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Term
|
Definition
|
|
Term
| 2nd gen extended spectrum against anaerobes |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| -Gram (+) cocci (EXCEPT MRSA) |
|
Definition
|
|
Term
| -PEcK: Proteus, E. coli, Klebsiella |
|
Definition
|
|
Term
| -Anaerobic cocci activity: peptococcus and peptostreptococcus |
|
Definition
|
|
Term
|
Definition
| Oral Cefadroxil, cephalexin, cephradine |
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|
Term
|
Definition
| Oral Cefadroxil, cephalexin, cephradine |
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|
Term
|
Definition
| Oral Cefadroxil, cephalexin, cephradine |
|
|
Term
|
Definition
| Oral Cefadroxil, cephalexin, cephradine |
|
|
Term
| DOC for surgical prophylaxis |
|
Definition
|
|
Term
| alt for penicillin allergies |
|
Definition
|
|
Term
Mixed anerobic infetions
-Peritonitis
-Diverticulitis |
|
Definition
|
|
Term
| what two 2nd gen can penetrate BBB |
|
Definition
|
|
Term
| tx for b-lactamase prod strains of H. influienza and Neisseria |
|
Definition
| Ceftriaxone and Cefotaxime |
|
|
Term
| tx for meningitis (H influenza, pneumococci, meningococi and susceptible enteric gram (-) rods |
|
Definition
| Ceftriaxone and Cefotaxime |
|
|
Term
| Tx for meningitis caused by highly resistant strains of pneumococci |
|
Definition
| Ceftriaxone or Cefotaxime PLUS vancomycin |
|
|
Term
| DOC for empiric therapy of serious infection and active agains most active penicillin resistant strains of pneumococci |
|
Definition
|
|
Term
| Emperical therapy for sepsis of unknown cause |
|
Definition
|
|
Term
| Neutropenic, fibrile, immunocompromised pts – tx with |
|
Definition
| Ceftriaxone (3rd generation) |
|
|
Term
-Enterobacter (more resistant to hydrolysis by chromosomeal b-lactamases)
-Pseudomonas aeruginosa, S. aureus, S. pneumoniae
-Highly active against Haemophilus and neisseria
-penetrates CNS |
|
Definition
|
|
Term
-Cephalosporins are excreted thru
-Exception? |
|
Definition
|
|
Term
| Organisms not covered by cephalosporins |
|
Definition
LAME
-Listeria monocytogenes
-Atypicals (Chlamydia, mycoplasma)
-MRSA
-Enterococci |
|
|
Term
| Which cephalosporin can cause Hypoprothrombinemia (cause bleeding) and disulfiram-like rxns? |
|
Definition
| Cefotetan (methylthiotetrazole) |
|
|
Term
-acts like penicillin (monobactam)
-spectrum similar to 3rd gen cephalosporins
-resistant to most b-lactamases
-can be given to penicillin-allergy pts
-can tx pneumonia, meningitis, and sepsis caused by gram (-) pathogens |
|
Definition
|
|
Term
-resistant to most b-lactamases
-inactivated by dehydropeptidase in renal tubules so must administer with cilastatin to inibit dehydropeptidase
-___________ + cilastatin
-only use for highly resistant strains |
|
Definition
|
|
Term
-N/V/D
-Skin rashes
-Renal failure
-Seizures
-penicillin allergy contraindication |
|
Definition
|
|
Term
| Binds D-Ala-D-Ala terminus preventing peptidoglycan elongation and cross linking |
|
Definition
|
|
Term
| Terminal D-Ala becomes D-lactate |
|
Definition
|
|
Term
| Bacteriocidal for gram (+) |
|
Definition
|
|
Term
| combo with Ceftriaxone or cefotaxime for tx of meningitis caused by highly penicillin resistant pneumococcus |
|
Definition
|
|
Term
| used orally only in tx of enterocolitis usu caused by C. diff and excreted unchanged in the urine |
|
Definition
|
|
Term
| Inhibits cell wall synthesis by interfering with lipid carrier that transfers peptidoglycan subunits to the growing cell wall |
|
Definition
|
|
Term
| Surface lesions of the skin, in wounds, or mucous membranes |
|
Definition
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