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peads gastroeneterolgy
.
47
Medical
Undergraduate 4
04/12/2017

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Term
out of possessing and regurg, which one would suggest the presence of GORD?
Definition
regurgitation
Term
red flag features in vomiting child. what would you think if you saw the following?
bile stained vomit
heamatemesis
projectile vomit in first few weeks of life
Definition
bile stained vomit: intestinal obstruction until proven otherwise
haematemesis: oesophagitis, peptic ulcer, oral/nose bleed
prohectile vomiting: pyloric stenosis
Term
red flag features in vomiting child. what would you think if you saw the following?

vomiting at the end of paroxysmal coughing?
abdo pain/tenderness?
abdo distension?
Definition
vomiting at the end of paroxysmal coughing: whooping cough
abdo tenderness/pain: surgical abdomen
abdo distension: intestinal obstruction including strangulated hernia
Term
red flag features in vomiting child. what would you think if you saw the following?
hepatosplenomegaly
blood in stool
severe dehydration/shock
Definition
hepatosplenomegaly: chronic liver disease
blood in stool: intususseption, gastroenteritis - salmonella or campylobacter
severe dehydration/shock: severe gastroenteritis, DKA, Systemic infection
Term
red flags

bulging fontanelle?
FTT
Definition
bulging fontanelle: raised ICP
FTT: GORD, coeliacs and other chronic GI conditions.
Term
features of intestinal obstruction and vomiting
Definition
the more proximal the obstruction the more prominent the vomiting and the sooner it becomes bile stained.

in distal obstruction abdominal distention is more marked.
Term
list complications of GORD in infants
Definition
FTT from severe vomiting
oesophagitis; haematemesis, discomfort on feeding or heartburn, iron deficiency anemia
recurrent pulmonary aspiration
dystonic neck posturing - SANDIFER syndrome
apparent life threatening events.
Term
what is SANDIFER SYNDROME?
Definition
involves spasmodic torsional dystonia with arching of the back and rigid opisthotonic posturing, mainly involving the neck, back, and upper extremities, associated with symptomatic gastroesophageal reflux, esophagitis, or the presence of hiatal hernia.
Term
what kind of infants is severe reflux more common in?
Definition
CP and other developmental disorders
preterm infants esp if co existent with bronchopulmonary dysplasia
following surgery for oesophageal atresia or diagphramatic hernia
Term
ix for reflux
Definition
24 hour pH monitoring to quantify reflux
24 impedance monitoring
endoscopy to exclude oesophagitis
Term
mx for infant GORD
Definition
parental reassurance
food thickeners e.g. Carobel
position in a 30 degree head up prone position after feeds
if significant reflux: ranitidine or omeprazole
then domperidone

if still present then consider cows milk protein allergy and do further ix.

surgical: nissen fundoplication
Term
features of pyloric stenosis
Definition
projectile vomiting
2-7 weeks peak presentation
> common in boys and first born
hypochloremic, hypokalemic, hyponatremic metabolic alkalosis
Term
what is the surgical rx for pyloric stenosis called?
Definition
pyloromyotomy
Term
what happens in colic
what are the DDX of colic
Definition
inconsolable crying infant who draws knees up passes a lot of flatus.
typically in first 4 weeks of life. resolves by 4 months
DDX
cows milk protein allergy
GORD
Term
surgical causes of acute abdominal pain
Definition
acute appendicitis
intestinal obstruction
intussusception
inguinal hernia
peritonitis
meckels diveticulum inflammed
pancreatitis
trauma
Term
medical causes of acute abdomen
Definition
gastroenteritis
UTI
HSP
DKA
sickle cell
hepatitis
IBD/IBS
constipation
recurrent abdominal pain of childhood
psychological
lead poisoning
idiopathic
Term
extra abdominal causes of acute abdomen
Definition
upper respiratory tract infection
lower lobe pneumonia
testicular torsion
hip and spine
Term
appendicitus features
Definition
uncommon in children <3 years old
anorexia with low grade fever
few instances of vomiting
central colicky abdo pain that localises to RIF
abdo pain aggravated by movement e.g. walking, coughing jumping, bumps on the road during a car journey
persistent tenderness with guarding in Mcburney's point.
Term
what is non specific abdominal pain associated with?
how long does it last before resolving?
Definition
associated with URTI and cervical lymphadenopathy
abdo pain resolves in 24-48 hours.
Term
features of intussusception
Definition
peak 3months and 2 years
paroxysmal severe colicky pain and pallor
infant goes pales esp around the mouth during attacks and draws up legs
initially recover between attacks but then get more lethargic
may refuse feeds, may vomit which can be bile stained depending on site of intussusception
sausage shaped mass often palpable in the abdomen.
red current jelly stools passed is a late sign but characteristic.
abdo distension and shock.
Term
when can you make the diagnosis of mesenteric adenitis?
Definition
children in whom large mesenteric nodes are seen at laporotomy/laporoscopy and who's appendix is normal
Term
define non specific abdominal pain?
Definition
pain which resolves in 24-48hours
less severe than appendicitis with variable tenderness in RIF
Term
intussussectipn
which is the most common site?
peak age of this occurring?
Definition
common site is ileum going into ceacum at ileocecal valve
peak presentational age is between 3months and 2 years
Term
presentation of intussuseption?
Definition
paroxysmal colicky pain with pallor, abdominal mass and red current jelly stool
shock is an important complication and requires treatment
Term
mx of intussuseption?
Definition
reduction is attempted via air insufflation unless peritonitis is present
if this is unsuccessful or if peritonitis is present then surgery is required.
Term
what is a mockers diverticulum and remnant of?
Definition
the vitello intestinal duct
Term
what usually presents in the first 1-3 days of life with intestinal obstruction from Ladd bands?
Definition
malrotation
Term
what ix would you do if a child presented with bilious vomiting?
Definition
urgent upper GI contrast study.

if there are signs of vascular compromise then you would need to do an urgent laparotomy
Term
if a child has epigastric pain at night and heamatemesis what diagnosis are you thinking?
Definition
duodenal ulcer.
Term
what is the most frequent cause of gastroenteritis in developed countries?
Definition
rotavirus
Term
if there is blood in the still with diarrhoea what would you think the broad causative organism is?
Definition
bacterial.
e.g campylobacter jejuni, shigella

with shigella there is usually accompanying high grade fever
Term
what is a Clinitest?
Definition
it is used to diagnose post gastroenteritis syndrome where there is a temporary lactose intolerance following gastroenteritis.

the positive test shows non absorbed sugar in the stools.
Term
in children 1-3months cefotaxime and ampicillin is given if suspected sepsis, what does ampicillin cover against?
Definition
listeria
Term
which condition can cause subacute sclerosing pan encephalitis?
Definition
measles
Term
how long should you rx for encephalitis with aciclovir in suspected or proven cases?
Definition
3 weeks.
Term
if a child has
fever >39 degrees
hypotension
diffuse erythematous macular rash

what are you thinking?
Definition
Toxic shock syndrome
Term
mx of toxic shock syndrome?
Definition
abx
3rd gen cephalosporin e.g. ceftriaxone with clindamycin

clindamycin acts on bacterial ribosomes to to switch off toxin production
Term
what is Nikolsky sign?
Definition
where areas of epidermis separate on gentle pressure.

seen in scalded skin syndrome and SJS
Term
there are currentl 8 well known human herpes viruses what are they?
Definition
HSV 1 and 2
varicella zoster
CMV
EBV
herpes virus 6,7 and 8
herpes 8 is associated with Kaposi sarcoma
Term
MOA of aciclovir?
Definition
viral DNA polymerase inhibitor
Term
a child has a rash and a week after he has cerebelitis with an ataxic gait. this resolves within a month

what is the causative organism of his rash and ataxic gait?
Definition
VZV
Term
what do you rx CMV with?
Definition
ganciclovir or
foscarnet

both have serious side effects
Term
what do HHV 6 and 7 commonly cause?
Definition
Roseola infantum

high fever with malaise lasting a few days
when fever wanes a generalised macular rash appears

HHV6 and 7 are a common cause for febrile convulsions
Term
what are the complication of parvo virus?
Definition
can cause aplastic crisis in haemolytic anemias e.g. sickle cell OR
hydrops in the fetus
Term
in which condition that can affect the coronary arteries do children get inflammation of their BCG vaccination site?
Definition
kawasakis

the platelet count rises typically in the second week of illness.
there is prolonged fever
Term
how to diagnose kawasaki. what symptoms do you need?
Definition
prolonged fever of >5 and 4 other features of
non purulent conjunctivitis
red mucus membranes: strawberry tongue, dry cracked lips
cervical lymphadenopathy
rash
red and oedematous palms and soles or peeling of fingers and toes
Term
a child is found to have a deficiency in CD18 and CD11b
what does this mean
what will happen as a consequence?
Definition
this means they have a deficiency in neutrophil surface adhesion molecules

this leads to the inability of neutrophils to migrate to sites of infection/inflammation
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