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PDA I Exam 4 Fall 2008
Noradrenergic Transmission I
49
Health Care
Professional
11/27/2008

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Term
Norepinephrine and epinephrine are found in:
Definition
Postganglionic sympathetic nerve ending
Term
In the biosynthesis of catecholamines:
Tyrosine is converted to this molecule by tyrosine hydroxylase.
Definition
DOPA
Term
In the biosynthesis of catecholamines:
DOPA is converted to this molecule by DOPA decarboxylase.
Definition
Dopamine
Term
In the biosynthesis of catecholamines:
Dopamine is converted to this molecule by Dopamine-B-hydroxylase.
Definition
Noradrenaline (Norepinephrine)
Term
In the biosynthesis of cathecholamines:
Noradrenaline (NE) is converted to this molecule by Phenylethanolamine-N-methyltransferase.
Definition
Adrenaline (Epinephrine)
Term
These two drugs are given to patients with Parkinson's Disease.
Definition
L-DOPA, carbidopa
Term
Carbidopa blocks this enzyme:
Definition
DOPA decarboxylase
Term
Tyrosine hydroxylase is found in the:
Definition
Cytosol
Term
Tyrosine hydroxylase is selective for:
Definition
L-tyrosine
Term
If you have a drug that blocks the synthesis of tyrosine hydroxylase, you will:
Definition
Block the synthesis of DOPA (and dopamine, NE, and E)
Term
This drug is a strong inhibitor of tyrosine hydroxylase. It is sometimes used in treatment of HTN.
Definition
alpha-methyltyrosine (Metyrosine)
Term
DOPA decarboxylase is found in:
Definition
Cytosol
Term
Is DOPA decarboxylase specific or non-specific?
Definition
Non-specific
Term
This drug used to treat Parkinson's Disease inhibits DOPA decarboxylase.
Definition
Carbidopa
Term
Dopamine-B-hydroxylase is found in the:
Definition
Synaptic vesicles
Term
Dopamine-B-hydroxylase is an indicator of:
Definition
Sympathetic nerve activity
Term
Phenylethanolamine-N-methyltransferase is located in the:
Definition
Adrenal medulla
Term
Phenylethanolamine-N-methyltransferase catalyzes the:
Definition
N-methylation of NE to E
Term
Epinephrine and NE are synthesized in the:
Definition
Adrenal Medulla
Term
Reserpine is a/an:
Definition
Inhibitor of the vesicular catecholamine pump
Term
In the sympathetic nervous system, this terminates the action of released NE:
Definition
Reuptake of the neurotransmitter
Term
Circulating EPI and NE are degraded by:
Definition
Monoamine Oxidase
Term
Cocaine, tricyclic antidepressants, phenoxybenzamine, and amphetamine are examples of:
Definition
Uptake 1 inhibitors
Term
Steroid hormones and phenoxybenzamine are examples of:
Definition
Uptake 2 inhibitors
Term
Reserpine is an example of:
Definition
Vesicular transporter inhibitor
Term
MAOs are located:
Definition
In the outer membrane of mitochondria
Term
MAOIs are used to treat:
Definition
Depression
Term
This molecule found in wine, sausage, and cheese causes adverse effects in MAOIs:
Definition
Tyramine
Term
In the presence of MAOIs, this is taken up causing a massive release of NE.
Definition
Tyramine
Term
Consuming wine, cheese, or sausage while taking an MAOI could cause:
Definition
Hypertensive crisis due to massive release of NE
Term
COMT inhibitors are used to treat:
Definition
Parkinson's Disease
Term
Tolcapone and entacapone are:
Definition
COMT inhibitors used to treat Parkinson's Disease
Term
Activation of these receptors decrease NE release:
Definition
Alpha-2 receptors
Term
Alpha and beta receptors are this kind of receptor
Definition
GPCR
Term
Alpha-1 and alpha-2 receptors exist:
Definition
Postsynaptically
Term
Activation of alpha-1 receptors causes this in blood vessels:
Definition
Vasoconstriction
Term
Alpha-2 receptors are located both:
Definition
Postsynaptically and presynaptically
Term
Phenylephrine is:
Definition
A selective alpha-1 agonist
Term
Clonidine is a:
Definition
Selective alpha-2 agonist
Term
Prazosin is a:
Definition
Selective alpha-1 antagonist
Term
Yohimbine is a:
Definition
Selective alpha-2 antagonist
Term
Alpha-1 receptors have this physiological effect:
Definition
Smooth muscle contraction
Term
Alpha-2 receptors cause this physiological effect:
Definition
Inhibition of transmitter release
Term
Alpha-1 receptors act through this GPCR:
Definition
Gq
Term
Alpha-2 receptors act through this GPCR:
Definition
Gi
Term
Beta-1 receptors are found primarily in:
Definition
Cardiac myocytes
Term
Beta-2 receptors are found primarily in:
Definition
Bronchial smooth muscle tissue
Term
Beta-3 receptors are found primarily in:
Definition
Adipose tissue
Term
Activation of beta-1 receptors causes these effects on the heart:
Definition
Increase contractile force; increase heart rate
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