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PDA Exam 2, Part 3
Natural Products- amino acid derivatives
16
Pharmacology
Professional
02/22/2012

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Cards

Term
List proteins considered primary metabolic products
Definition
Amino acids
Term
List three primary metabolites derived from aromatic amino acids
Definition
1. Phenols
2. Tannins
3. Lignin
Term
List three secondary metabolites derived from aliphatic amino acids
Definition
1. Alkaloids
2. Peptides
3. Penicillin
Term
Define alkaloid
Definition
Naturally occurring, organic nitrogenous compounds that are usually basic and derived from amino acids

Derived from plants
Term
Define true alkaloids
Definition
Products derived from amino acids with nitrogen in a ring structure
Term
How are proto-alkaloids different from true alkaloids?
Definition
Derived from amino acids, but the nitrogen is in a side chain instead of a ring
Term
How are pseudo-alkaloids different from true alkaloids?
Definition
Products that behave like alkaloids and nitrogen in ring structure

But are NOT derived from amino aicds

Produced in mammals
Term
List properties of alkaloids
Definition
-Solids (usually)
-Basic in nature
-Base and salt forms
-Precipitate with alkaloidal reagents
-Watch for toxicity
Term
List two alkaloidal reagents
Definition
-Mayer's Reagent
-Dragendorff's Reagent
Term
List a few of the major classes of alkaloids
Definition
1. Nicotine
2. Atropine
3. Quinine
4. Caffeine
5. Anything with a pyrrole or imidazole
6. Purines
Term
What two types of alkaloids are derived from tyrosine?
Definition
Isoquinoline alkaloids
Phenanthrene alkaloids
Term
How can you test a solution for morphine?
Definition
Add ferrous solution, it will react with meconic acid (found with morphine)
Term
How do you classify alkaloids?
Definition
1. Look where the nitrogen is. Decide if it is a true alkaloid or pseudo-alkaloid.

2. See what amino acid structure contributed the N
Term
List five antibiotics derived from amino acid metabolism
Definition
1. Penicillins
2. Cephalosporins
3. Chloramphenicol
4. Cycloserine
5. Dactinomycin
Term
What amino acids contribute to the structure of penicillin?
Definition
Cysteine, Valine, Phenylalanine
Term
List two polypeptide antibiotics that are composed of both L and D acids
Definition
Bacitracin, polymyxin
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