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PCOL I Exam 2 Drugs
Nicotinic Agonists & Antagonists, Adrenergic Agonists & Antagonists, VGCC Antagonists, Cholesterol Drugs
82
Pharmacology
Graduate
10/22/2012
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Term
varenicline
 Definition
Chantix; partial nicotinic agonist
use: smoking cessation
Term
succinylcholine
 Definition
depolarizing NMJ blocker; nicotinic agonsist
effect:: paralysis
use: surgery
contraindications: pseudocholinesterase deficiency (permanent paralysis) & malignant hyperthermia (muscle shivering causes dangerous rise in body T)
Term
vecuronium
 Definition
nicotinic antagonist
effect: paralysis for surgery
Term
doxacurium
 Definition
nicotinic antagonist
effect: paralysis for surgery
Term
cisatracurium
 Definition
nicotinic antagonist
effect: paralysis for surgery
Term
rocuronium
 Definition
nicotinic antagonist
effect: paralysis for surgery
Term
rapacuronium
 Definition
nicotinic antagonist effect: paralysis for surgery; very selective for NMJ receptor
Term
mivacurium
 Definition
nicotinic antagonist
effect: paralysis for surgery; releases histamine
very selective for NMJ receptor
short acting
Term
pancuronium
 Definition
nicotinic antagonist
effect: paralysis for surgery
less selective for NMJ receptor
long acting
Term
dobutamine
 Definition
beta-1 agonist
effect: positive inotropy > positive chronotropy
use: acute CHF
tachyphylaxis occurs; use for first few days
Term
acebutolol
 Definition
beta-1 antagonist
(partial agonist)
Term
atenolol
 Definition
beta-1 antagonist
Tenormin
Term
betaxolol
 Definition
beta-1 antagonist
Term
bisoprolol
 Definition
beta-1 antagonist
Term
metaprolol
 Definition
beta-1 antagonist
Lopressor, Toprol XL
Term
esmolol
 Definition
beta-1 antagonist
Brevibloc
IV, short acting
Term
albuterol
 Definition
beta-2 agonist
Term
bitolterol
 Definition
beta-2 agonist
Tornalate
Term
formoterol
 Definition
beta-2 agonist
Foradil
Term
isoetharine
 Definition
beta-2 agonist
Term
levalbuteral
 Definition
beta-2 agonist
Xopenex
Term
metaproterenol
 Definition
beta-2 agonist
Alupent
Term
pirbuterol
 Definition
beta-2 agonist
Maxair
Term
salmeterol
 Definition
beta-2 agonist
Serevent
Term
terbutaline
 Definition
beta-2 agonist
Term
ritodrine
 Definition
beta-2 agonist
IV
use: tocolytic
Term
isoproterenol
 Definition
nonselective beta agonist
Term
roflumilast
 Definition
phoshphodiesterase-4 inhibitor
Daliresp
use: COPD, asthma
Term
propranolol
 Definition
nonselective beta antagonist
Term
nadolol
 Definition
nonselective beta antagonist
Term
pindolol
 Definition
nonselective beta antagonist
Term
sotalol
 Definition
nonselective beta antagonist
Term
timolol
 Definition
nonselective beta antagonist
Term
levobunalol
 Definition
nonselective beta antagonist
Term
midodrine
 Definition
alpha-1 agonist
Term
phenylephrine
 Definition
alpha-1 agonist
eyedrop, tablet, IV, nasal spray
Term
pseudoephedrine
 Definition
alpha-1 agonist
Sudafed
Term
oxymetazoline
 Definition
alpha-1 agonist
Afrin
Term
prazosin
 Definition
alpha-1 antagonist
Term
terazosin
 Definition
alpha-1 antagonist
Hytrin
Term
doxazosin
 Definition
alpha-1 antagonist
Cardura
Term
alfuzosin
 Definition
alpha-1 antagonist
Uroxatral
Term
silodosin
 Definition
alpha-1 antagonist
Rapaflo
Term
tamsulosin
 Definition
alpha-1A selective antagonist
Flomax
Term
labetalol
 Definition
alpha-1, beta-1, beta-2 antagonist
Term
carvedilol
 Definition
alpha-1, beta-1, beta-2 antagonist
Coreg
Term
clonidine
 Definition
alpha-2 agonist
Catapres
Term
methyldopa
 Definition
alpha-2 agonist
Term
guanabenz
 Definition
alpha-2 agonist
Term
guanfacine
 Definition
alpha-2 agonist
Tenex
Term
dexmedetomidine
 Definition
alpha-2 agonist
Term
brimonidine
 Definition
alpha-2 agonist
Alphagan
Term
apraclonidine
 Definition
alpha-2 agonist
Term
yohimbine
 Definition
alpha-2 antagonist
Term
phentolamine
 Definition
nonselective alpha antagonist
Term
phenoxybenzamine
 Definition
nonselective alpha antagonist
Term
verapamil
 Definition
nonDHP CCB
more negative inotropy than diltiazem
Term
diltiazem
 Definition
nonDHP CCB
Term
amlodipine
 Definition
DHP CCB
no first pass effect :)
Term
clevidipine
 Definition
DHP CCB
Term
felodipine
 Definition
DHP CCB
Term
isradipine
 Definition
DHP CCB
Term
nicardipine
 Definition
DHP CCB
Term
nifedipine
 Definition
DHP CCB
Term
nimodipione
 Definition
DHP CCB
Term
nisoldipine
 Definition
DHP CCB
Term
pitavastatin
 Definition
HMG CoA Reductase Inhibitor
Term
atorvastatin
 Definition
HMG CoA Reductase Inhibitor
Term
rosuvastatin
 Definition
HMG CoA Reductase Inhibitor
Term
pravastatin
 Definition
HMG CoA Reductase Inhibitor
Term
simvastatin
 Definition
HMG CoA Reductase Inhibitor
Term
fluvastatin
 Definition
HMG CoA Reductase Inhibitor
Term
lovastatin
 Definition
HMG CoA Reductase Inhibitor
Term
cholestyramine
 Definition
Bile acid sequestrant
Term
colestipol
 Definition
Bile acid sequestrant
Term
colesevalem
 Definition
Bile acid sequestrant
Term
gemfibrozil
 Definition
fibrate
Term
fenofibrate
 Definition
fibrate
Term
niacin
 Definition
effect: inhibit cAMP -> inhibit TG synthesis & lipolysis
Term
ezetimibe
 Definition
cholesterol absorption inhibitor in smint
Term
CETP inhibitor
 Definition
HDL cannot transfer to VLDL/LDL -> increase HDL
(future drug)
Term
PSCK9 inhibitor
 Definition
LDL receptor cannot degrade -> more LDL receptors on surface -> decrease LDL
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