Term
| What is the Schilling test? |
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Definition
| Urine test that indicates B12 absorbed through GI tract |
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Term
| Why are the megaloblastic cells in folate or B12 deficiency? |
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Definition
| Slowed cell division, normal cytoplasmic development |
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Term
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Definition
| Abx, analogues of PABA (part of folate), prevent cell division by interfering with folate synthesis |
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Term
| How much folate should a woman capable of becoming pregnant have per day? |
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Definition
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Term
| Why is FH4 required for cell division? |
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Definition
| It is required for the synthesis of dTMP and purine bases used to produce precursors for DNA replication |
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Term
| What are the 2 reactions B12 is involved with? |
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Definition
| Transfer of a methyl group from N5-methyl-FH4 to homocysteine to form methionine, and the rearrangement of methylmalonyl CoA to form succinyl CoA |
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Term
| Where does SAM come from? |
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Definition
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Term
| How is homocysteine converted into methionine? |
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Definition
| From B12 donating a methyl group |
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Term
| When SAM transfers a methyl group, what are the products? |
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Definition
| SAH --> homocysteine and adenosine |
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