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PBL Test 2: Biochemistry - FH4, Vit B12 and SAM
Biochemistry of folate and Vitamin B12
9
Biochemistry
Professional
11/03/2010

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Cards

Term
What is the Schilling test?
Definition
Urine test that indicates B12 absorbed through GI tract
Term
Why are the megaloblastic cells in folate or B12 deficiency?
Definition
Slowed cell division, normal cytoplasmic development
Term
What are sulfa drugs?
Definition
Abx, analogues of PABA (part of folate), prevent cell division by interfering with folate synthesis
Term
How much folate should a woman capable of becoming pregnant have per day?
Definition
400ug
Term
Why is FH4 required for cell division?
Definition
It is required for the synthesis of dTMP and purine bases used to produce precursors for DNA replication
Term
What are the 2 reactions B12 is involved with?
Definition
Transfer of a methyl group from N5-methyl-FH4 to homocysteine to form methionine, and the rearrangement of methylmalonyl CoA to form succinyl CoA
Term
Where does SAM come from?
Definition
activation of methionine
Term
How is homocysteine converted into methionine?
Definition
From B12 donating a methyl group
Term
When SAM transfers a methyl group, what are the products?
Definition
SAH --> homocysteine and adenosine
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