Caused by deficiency of essential fatty acids

May occur in patients receiving total parenteral nutrition

Suppress the transcription and translation of COX-2

Induce the synthesis of a protein or family of proteins that inhibit the activity of phospholipase A2

Predominant eicosanoid in platelets

Vasoconstrictor, platelet aggregation stimulant

Permanently destroys the COX enzyme by covalently acetylating the active site

Effective in prevention of acute MI

Less effective in stimulating platelet aggregation than its counterpart

Production stimulated by diets high in polyunsatuated fatty acids

Can be used to treat male impotence

Can maintain PDA until surgery can be performed

Stimulate uterine muscle contraction

Used to induce labor and control postpartum bleeding