Term
| Insuffiecient exocrine pancreas secretion leads to _______________. |
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Definition
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Term
| Exocrine pancreas plays a vital role in digestion. What 2 things must occur as the chyme goes from the stomach to the small intestine? |
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Definition
1. Acid must be quickly and efficiently neutralized
2. Macromolecular nutrients must be broken down even further before reabsorbed into the blood. |
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Term
| The endocrine portion of the pancreas secretes which hormones? |
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Definition
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Term
| The endocrine pancreas plays a role in ________________ and ______________ metabolism and maintains normal blood glucose concentration. |
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Definition
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Term
| The cells of pancreas are arranged in grape like clusters called _____________. These secrete the enzyme component of pancreatic juice. |
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Definition
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Term
| The substances made by the acini are drained into _____________ that drain into the ________________-. |
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Definition
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Term
| Which cells make the fluid component of the pancreatic juice? |
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Definition
| The columnar epithelial cells that line the ducts |
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Term
| How much pancreatic juice is secreted per day? |
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Definition
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Term
| Exocrine pancreatic juice is composed of an ____________________ component and an _______________ component. |
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Definition
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Term
| The enzyme component of the exocrine juice helps to digest carbohydrates, fats, and proteins secreted by _____________. |
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Definition
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Term
| What types of signals control pancreatic secretions? |
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Definition
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Term
| What things trigger the signals for pancreatic secretion? |
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Definition
1. Presence of acid
2. Presence of digestion products in the duodenum |
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Term
| Where is CCK released from? |
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Definition
| The I cells in the duodenum |
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Term
| What 2 things trigger the release of CCK from the I cells? |
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Definition
CCK releasing factor
Monitor peptide |
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Term
| CCK releasing factor is secreted in the ________________ where as the monitor peptide is by _______________. |
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Definition
Small intestine
Pancreatic acinar cells |
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Term
| Both CCK releasing factors and monitor peptide are released in response to ___________ signals. |
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Definition
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Term
| The secretion of the ____________cells and cells of the _______________ make up the enzyme component of pancreatic juice. |
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Definition
Acinar cells
Intercalated ducts |
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Term
| The major proteases in the intestine for the digestion of proteins are: |
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Definition
1. Trypsin
2. Chymotrypsin
3. Carboxypeptidase |
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Term
| Trypsinogen is converted to trypsin by _____________- in the intestine. |
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Definition
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Term
| Chymotrypsinogen is converted to chymotrypsin by _____________ in the intestine. |
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Definition
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Term
| Procarboxypeptidase is converted to carboxypeptidase by ______________ in the intestine. |
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Definition
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Term
| ____________ and ____________ are both proteolytic digestive enzyme that catalyzes the breakdown of dietary proteins to peptones, peptides and A.A. |
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Definition
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Term
| Carboxypeptidase cleaves peptides from _________. |
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Definition
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Term
| What are the major lipases in pancreatic juice? |
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Definition
1. Triacylglycerol hydrolase
2. Cholesterol ester hydrolase
3. Phospholipase A2 |
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Term
| Which 3 things lead to increase secretion of pancreatic juices? |
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Definition
1. AcH
2. Secretin
3. CCK |
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Term
| The aqueous component of pancreatic juice is produced primarily by the columnar epithelial cells that line the ducts that is rich in __________. |
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Definition
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Term
| Describe the hormonal regulation of pancreatic aqueous secretion. |
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Definition
AcH binds to M3R that is coupled to Gq.
Increases in IP3 which then binds to IP3R.
Increase release of Ca2+
Activates AQP8 to secreted H2O |
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Term
| ____________ hormonal regulation allows for both aqueous and HCO3- secretion via activating cAMP and thus PKA. |
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Definition
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Term
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Definition
| When food is chewed but not swallowed |
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Term
| What occurs during the cephalic phase of pancreatic juice release? |
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Definition
Sham feeding induces secretion of a low volume of pancreatic jucie with a high protein content.
(lots of amylase) |
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Term
| What type of impulses stimualte pancreatic secretion? |
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Definition
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Term
| During the gastric phase of pancreatic secretion, distention of the stomach elicits vagal reflexes that induce the pancreas to secrete a small volume of juices with a high _________________. |
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Definition
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Term
| What occurs during the intestinal phase of pancreatic secreation? |
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Definition
1. Acid in the chyme in the duodenum and upper jejunum secrete large volume of pancreatic juice with low enzyme concentration.
2. Also releases secretin |
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Term
| Secretin directly stimulates pancreatic _____________ cells to secrete ______________ component of the pancreatic juice. |
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Definition
Ductular epithelial
HCO3- |
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Term
| What things elicit pancreatic juice secretion that is rich in enzyme components during the intestinal phase? |
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Definition
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