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PBD II Exam 2 Millard
N/A
14
Physiology
Graduate
02/09/2011

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Cards

Term
Where in the hypothalamus are the cell bodies that release GHRH?
Definition
arcuate nucleus
Term
How many forms of GHRH are there and how many amino acids are each?
Definition
2 forms, 40 and 44
Term
How many forms of Somatostatin are there and what is the chain length of each?
Definition
2 forms, 14 and 28 AAs
Term
T/F Plasma levels of GH are very episodic.
Definition
T
Term
____ leads to surges of GH, whereas ____ inhibits secretion of GH
Definition
GHRH, SRIF
Term
Besides GHRH, what is the other potent stimulator of GH secretion? Does it act on the same receptor as GHRH?
Definition
ghrelin, no (GH secretagogue receptor)
Term
Which amino acid is known to stimulate the hypothalamus to produce GHRH?
Definition
Arginine
Term
Amino acids, niacin, serotonin, dopamine, stress, and sleep stimulate/inhibit the release of GHRH?
Definition
stimulate!
Term
Where are the cell bodies that release SRIF located?
Definition
periventricular area of hypothalamus
Term
What hormone is responsible for the long-loop feedback control of GH? Increase in this hormone leads to an increase/decrease in GHRH and an increase/decrease in SRIF.
Definition
IGF-1, dec GHRH, inc SRIF
Term
What effect does IGF-1 have on the pituitary?
Definition
interferes with GHRH binding
Term
What hormone is responsible for the short-loop feedback control of GH?
Definition
GH. Negative feedback on the brain to dec GHRH and inc SRIF
Term
What hormones regulate the ultra-short-loop feedback control of GH
Definition
GHRH and SRIF. Involved in moment to moment GH secretion
Term
The actions of GH are mediated via a class of proteins called _____?
Definition
Insulin-like growth factors (IGFs)
The synthesis of IGF-1 is induced by GH.
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