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Pathophysiology
Disorders of Blood Flow and Oxygenation
43
Medical
Undergraduate 3
08/19/2008

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Term
Pericardium
Definition
double walled membranous sac that encloses heart. Layers separated by serous fluid.

1.pulses paradoxus
2.muffled heart sounds
3.poorly palpable pulses
Term
Myocardium
Definition
cardiac muscle
Term
Endocardium
Definition
internal lining
Term
Acute pericarditis
Definition
1. Definition: acute inflammation of pericardium, etiology unknown or infection
2. Pathophysiology: membrane becomes inflamed, roughened, exudate may form
3. Clinical Manifestations:
a.chest pain
b. restlessness, anxiety
c. low grade fever
d. friction rub

4. Complications:
a. Pericardial effusion: excess pericardial fluid. Can compress adjoining structures - pulmonary tissues
b. Cardiac tamponade: effusion inc in size or occurs rapidly. Fluid and pressure compromises heart’s ability to fill and empty
1. pulses paradoxus
2. muffled heart sounds
3. poorly palpable pulses

5. Diagnostic Tests:
a. EKG
b. echocardiogram

6. Treatment:
a. treat cause
b. pain meds
c. pericardiocentesis
Term
exudate
Definition
An exudate is any fluid that filters from the circulatory system into lesions or areas of inflammation流出物,分泌液
Term
Lesion
Definition
any abnormal tissue found on or in an organism, usually damaged by disease or trauma. Lesion is derived from the Latin word laesio which means injury.n. 损害,损伤精神的伤害,障碍
Term
effusion
Definition
In chemistry, effusion is the process where individual molecules flow through a hole without collisions between molecules.n. 流出,溢出
Term
Diffusion
Definition
n. 散布,传播,蔓延
Term
Pericardial effusion
Definition
excess pericardial fluid. Can compress adjoining structures - pulmonary tissues
Term
Cardiac tamponade
Definition
an emergency condition in which fluid accumulates in the pericardium (the sac in which the heart is enclosed). If the fluid significantly elevates the pressure on the heart it will prevent the heart's ventricles from filling properly. This in turn leads to a low stroke volume. The end result is ineffective pumping of blood, shock, and often death.
Term
aspirate
Definition
v. 送气发音,吐气,吸出
n. h音,气音字,h字
a. 气音的,h音的
Term
pericardiocentesis
Definition
a procedure where fluid is aspirated from the pericardium
Term
Constrictive Pericarditis
Definition
chronic inflammation of pericardium, etiology unknown but associated with radiation, cancer, rheumatoid arthritis
Term
Constrictive Pericarditis

Pathophysiology
Definition
fibrous scarring, pericardial layers adhere. Encases heart in rigid shell
Term
Constrictive Pericarditis
Clinical Manifestations
Definition
a. fatigue, weakness
b. SOB on exertion
c. exercise intolerance
d. edema
e. distention of jugular vein
f. hepatic congestion

4. Diagnostic Tests
a. EKG changes b. echocardiogram

5. Treatment
a. digoxin b. diuretics
c. Na restrictions
d. surgery
Term
edema
[i(:)'di:mə]
Definition
the increase of interstitial fluid in any organ — swelling
浮肿,水肿
Term
distention
Definition
n. 膨胀
Term
jugular vein
Definition
The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava.
Term
Cardiomyopathies
Definition
心肌症
literally means "heart muscle disease," is the deterioration of the function of the myocardium (i.e., the actual heart muscle) for any reason. People with cardiomyopathy are often at risk of arrhythmia or sudden cardiac death or both.
Term
Dilated Cardiomyopathy
Definition
inflammation and degeneration of myocardial fibers that dec contractile function. Chambers dilate – causes impaired pumping function. Dec L ventricular ejection fraction and dec CO. Leads to inc in volumes in heart.
Term
Erosion
Definition
n. 腐蚀,侵蚀
Term
echocardiogram
Definition
超声波心动(描记)图
Term
pericardiocentesis
Definition
心包(放液)穿刺术
Term
arrhythmia
Definition
an abnormal rate of muscle contractions in the heart
Term
hypertrophied
Definition
(thickened)
Term
Hypertrophic cardiomyopathy
Definition
myocardial hypertrophy without dilation. Walls hypertrophy, thick septum so small volumes. Hypertrophy also causes impaired relaxation. Possible aortic outflow obstruction
Term
angina
Definition
n. 咽峡炎,狭心症
Term
syncope
['siŋkəpi]
Definition
loss of consciousness, fainting
n. 字中音省略,中略,假死
Term
CXR
Definition
Chest X-Ray
Term
Restrictive Cardiomyopathy
Definition
Term
stiff
Definition
a. 坚硬的,严厉的,呆板的
ad. 僵硬地,彻底地
Term
emboli
Definition
In medicine, an embolism occurs when an object (the embolus, plural emboli) migrates from one part of the body (through circulation) and causes a blockage (occlusion) of a blood vessel in another part of the body.
Term
arthralgia
Definition
关节痛
关节疼痛
Term
WBC
Definition
White Blood Count (WBC)
Term
Rheumatic Fever/Heart Disease
Definition
inflammatory disease caused by delayed infection by group A beta-hemolytic strept
Rheumatic fever is an autoimmune inflammatory disease which may develop after a Group A streptococcal infection (such as strep throat or scarlet fever) and can involve the heart, joints, skin, and brain. It commonly appears in children ages 6 through 15 .
Term
Rheumatic Fever

Pathophysiology:
Definition
RF sequel to pharyngeal infection. Abnormal immune response to group A strept cell membrane antigen. Antigens bind to receptors in heart -> Inflammatory lesions develop and damage valves.
Term
polyarthritis
[ˌpɔliɑ:'θraitis]
Definition
n. [医]多发性关节炎
Term
Chorea
Definition
an abnormal involuntary movement disorder
Term
erythema
[ˌeri'θi:mə]
Definition
n. 红斑
Term
Valvular Disease:
Stenosis
Definition
valve opening constricted. Chamber in front of valve - work harder, hypertrophy
Term
Stenosis
[sti'nəusis]
Definition
[医](器官)狭窄
valve opening constricted. Chamber in front of valve - work harder, hypertrophy
Term
Regurgitation
[riˌgɜ:dʒi'teiʃən,ri:-]
Definition
n. 流回,逆流,反刍
valve does not close all the way, allows blood to flow in reverse. Inc volume – hypertrophy and dilation of chamber
Term
Mitral Valve Prolapse
Definition
failure of one or both valves leaflets to fit together. Usually benign, can lead to mitral regurgitation and inc risk of endocarditis
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