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Fever Tachycardia Leukocytosis • Pain |
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Water Lipids and Carbohydrates Glycogen Proteins Pigments Calcium Urate |
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| failure of the cells to receive or utilize oxygen |
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| tear or rip skin (common with the elderly) |
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| Chemical Mechanism of Cellular injury: Mercury |
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Definition
Dental amalgams Fish consumption Vaccines |
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Microcephaly- small brain Low birth weight Cardiovascular defects Developmental disabilities Physical- sm head and features Mental- decreased cognition speech problems, retardation at different levels. |
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Mechanisms of Cellular Injury: Chemical Lead |
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Definition
| alters nervous system and affect Ca(affects clotting factors- bleeding). |
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| Free Radicals Cause damage by |
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Definition
Lipid peroxidation(Failure of Na-K pumps)-destruction of polysaturated lipids; changes permeability. • Attacking critical proteins- no nutritional source; delayed wound healing. Fragmenting DNA- cannot create proteins(essential to life). Damaging mitochondria- damages the powerhouse(no ATP prod) |
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| oxygen restored to the cell, but not to function normally causing permanent injury. |
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| cells are shrinking (not decreasing in #) |
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| normal shrinking; thymus shrinks to nothing during childhood. |
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| cells are shrinking; abnormal response because of…decreased workload, increase in pressure, low blood supply ect… |
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| cells are shrinking-no use of muscle (in a cast, paralysis) |
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| cells increase in size-normal increase; body builder |
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| cells increase in size-abnormal response; heart enlarged due to increased workload (hypertension). |
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| increase in # of cells(regeneration) physiologic response to maintain body function. |
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| increase # of cells in hormonal dependent organs ( ex. Estrogen during pregnancy) |
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| cell changes and no longer functions as a cell, changes composition. |
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| adaptive response; (reversible) changes cell type in response to an irritant; will revert to normal once irritant is removed. |
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| breakdown of protein and enzyme |
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Term
| Coagulative Necrosis: Occurs & Characteristics |
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Definition
| Occurs: Kidneys, heart, adrenal glands; Appearance: gelatinous, transparent state to a firm, opaque state |
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Term
| Liquefactive Necrosis: Cause & Characteristics |
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Definition
| Patho: Bacterial infection staphylococci, streptococci, and Escherichia coli; Appearance: tissue soft, liquefies, and walled off from healthy tissue, forming cysts |
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| Caseous Necrosis: cause and characteristics |
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Definition
| COMBO infection caused by Mycobacterium tuberculosis;Appearance: tissues resemble cottage cheese; inflammatory wall encloses areas of caseous necrosis |
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