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Pathophysiology Test #3
Lectues
10
Nursing
Graduate
07/24/2011

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Term
characteristics of cancer cells
Definition
1. lack of contact inhibition
2. inability to differentiate
3. derive from a single cell
4. abnormal cell proliferation
5. local tumor formation
6. invasion of surrounding tissue
7. ability to metastasize
Term
Steps of initiation
Definition
1. carcinogen damages DNA
2. Changes a specific gene in cell
3. Gene undergoes repair
4. Gene mutates or mutate and produces cancer cell line
Term
oncogenes
Definition
genes that encode proteins to promote cellular proliferation
Term
deregulation
Definition
mutations in proto-oncogene yields uncontrolled growth stimulatory proteins
Term
Promotion results in:
Definition
uncontrolled growth and replication of cells
Term
growth factors
Definition
polypeptides that influence cellular growth, differentiation, and survival
Term
promotion
Definition
-energize growth stimulating pathways to stay open
-signal protein receptors in cytoplasm to proliferate
-transmit growth stimulating signals to other growth factor receptor cells in tissue
-Signal transcription factors to induce cell cycle
Term
angiogenesis
Definition
tumors form new blood vessels
Term
metastasis
Definition
cancer cells can form new colonies
Term
metastasis
Definition
cancer cells can form new colonies
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