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Pathophysiology Exam 6
Final Exam - Reproductive & Integumentary Systems
72
Pathology
Undergraduate 2
12/04/2013

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Cards

Term
Primary Skin Lesions
Definition
Macule, Patch, Papule, Plaque, Nodule, Tumor,Vesicle, Bulla, Pustule, Cyst, Wheal, Telangiectasia
Term
Macule
Definition
flat, non-palpable, less than 1 cm
(Measles, freckles, petechiae, scarlet fever)
Term
Patch
Definition
flat, non-palpable, greater than 1 cm
(Vitiligo, port wine stain, mongolian spots, cafe-au-lait spot)
Term
Plaque
Definition
elevated, firm, rough with flat top, greater than 1 cm (psoriasis, seborrheic and atinic keratosis)
Term
Nodule
Definition
deeper, firmer than papule, palpable, 1-2 cm (hypertrophic nodule, lipomas)
Term
Tumor
Definition
elevated, solid, deeper in dermis, greater than 2 cm (hemangioma, neoplasms)
Term
Papule
Definition
elevated, palpable, less than 1 cm (wart, verruca, elevated moles, lichen planus)
Term
Vesicle
Definition
serous fluid-filled elevated less than 1 cm (chicken pox, herpes zoster/shingles)
Term
Bulla
Definition
serous fluid-filled elevated, greater than 1 cm (blister)
Term
Pustule
Definition
filled w/ pus, elevated (Acne)
Term
Wheal
Definition
transitory palpable lesion (insect bites, uticaria, allergic reactions)
Term
Telangiectasia
Definition
fine, irregular red lines due to capillary dilation (rosacea)
Term
Cyst
Definition
filled with liquid or semi-solid material elevated (sebaceous cyst, cystic acne)
Term
Secondary Skin lesions
Definition
result from change in primary lesions
Term
Crust
Definition
(scab, eczema) dried pus, lymph or blood
Term
Erosion
Definition
depressed, moist, glistening (chicken pox or small pox after rupture)
Term
Scar
Definition
fibrous tissue that replaces normal skin after injury (hypertrophic scar, healed wound or surgical incision)
Term
Keloid
Definition
excessive collagen formation during healing; more common in African Americans; will always heal that way can't remove
Term
Excoriation
Definition
loss of epidermis, depressed (scabies, abrasion or scratch)
Term
Fissure
Definition
crack from epidermis to dermis (athletes foot, cracks at the corners of the mouth)
Term
Scale
Definition
flaky skin (seborrheic dermatitis after scarlet fever)
Term
Follicular phase
Definition
FSH induces growth of follicles
Follicle secretes estrogen
Estrogen stimulates endometrial growth
Term
Luteal phase
Definition
LH induces ovulation
Corpus luteum secretes estrogen and progesterone
Endometrium continues to thicken
Term
Menstruation starts new cycle
Definition
Drop in estrogen and progesterone starts menstrual flow
Term
BRCA
Definition
breast cancer gene; Only 5-10% of breast cancers are attributable to inherited genetic mutation
Term
Benign prostatic hyperplasia
Definition
Increase in number of prostate gland cells increases size
Causes urinary frequency, diminished force of urine stream, feeling of incomplete emptying, overflow incontinence, post void dribbling, distended bladder, enlarged prostate on rectal exam
Term
prostate cancer
Definition
2nd most common malignancy in men in U.S. 3rd most common cause of cancer deaths in men over 55
Unknown cause
Originates in periphery of gland, so well-established before symptoms of urinary difficulties from urethral obstruction occur
Term
benign prostatic hyperplasia and prostate cancer
Definition
Have no relationship
Term
Herpes simplex Type 1: HSV-1
Definition
typically infects the oropharyngeal areal causing facial, oral, and lip lesions, but may cause genital herpes
Term
Herpes simplex Type 2: HSV-2
Definition
usual cause of genital herpes; spread through direct contact of virus with mucosa or any skin break, nearly 80% of HSV transmission occurs during asymptomatic shedding of virus
Term
Cervical carcinoma risk factors
Definition
Major risk factor: incection with human papilloma virus (HPV), other risk factors: sexual activity at young age, increasing numbers of sexual partners, poor nutrition, smoking
Term
Endometrial cancer risk factors
Definition
unopposed estrogen therapy, obesity, early menarche, nulliparity, late menopause, diabetes, hereditary nonplyposis colorectal cancer, gallbladder disease, personal history of breast or ovarian cancer
Term
Fibrocystic breast disease risk factors
Definition
Excess estrogen and lack of progesterone during luteal phase
Term
Epididymitis
Definition
inflammatory response from infection or trauma in the epididymis (where the sperm travels through and matures); infection spreads from urethritis or prostatitis, indwelling urinary catheter, organisms from pharynx and tuberculosis travel through bloodstream
Term
Orchitis
Definition
inflammation of the testis, serious complication of epididymitis, major routhe of infection through the bloodstream, most common cause is mumps virus
Term
Testicular cancer
Definition
risk factors: hx of undesended testicle (cryptorchidism), klinefelter’s syndrome (XXY), peak age 15-35 years old
Term
Gonorrhea
Definition
direct mucosal-to-mucosal contact is necessary for transmission, not everyone exposed acquires the disease, risk of transmission is greater from male to female than female to male, can spread through bloodstream causing gonococcal bacteremia
Term
Syphilis
Definition
almost exclusively through sexual transmission, through direct contact between a moist infected lesion and any break in the skin or mucosa; if untreated becomes chronic systemic infection w/ three phases:
Term
Primary syphilis
Definition
chancre heals spontaneously in 4-6 weeks
Term
Secondary syphilis
Definition
rash on palms an soles most common
Term
Tertiary syphilis
Definition
occurs years to decades after initial infection, spreads to various organs causing lesions or gummas (small nodular masses of granulation tissue with necrotic centers surrounded by inflammation)
Term
Testicular cancer screening recommendations
Definition
monthly testicular self-examination for all men over 15 years old
Term
Prostate cancer screening recommendations
Definition
Digital rectal exam: annually for all men over 40 (unless found in family members at a younger age); Serum prostate-specific antigen (PSA) – annually at 40 yrs for African-Americans or family history of prostate cancer, annually for all men over 50 years; diagnosis confirmed by needle biopsy
Term
Cervical cancer
Definition
pap smear and pelvic exam annually for all women who are sexually active or age 18
Term
Testicular torsion
Definition
testis twists within scrotal sac and cuts off blood supply (can end up w/ necrotic testicles) can occur after trauma to testes or while asleep due to spasm of cremaster muscle, time is important salvage rate 70% between 6-12 hours, 20% after 12 hours
Term
Varicocele
Definition
Abnormal dilation of veins in scrotum, usually no symptoms, may feel heavy or tender, on palpation feels like bag of worms, surgical removal
Term
chronic prostatitis is a major cause of
Definition
Recurrent urinary tract infections in men
Term
Premenstrual syndrome (PMS) treatment
Definition
exercise, diet change, avoid salt, alcohol, caffeine, or oral contraceptive pills
Term
Testicular torsion treatment
Definition
surgical emergency within 6 hours (orchiopexy), ochidectomy(removal of testicle) if necrotic
Term
Hydrocele treatment
Definition
surgical-hydrocelectomy
Term
Varicocele treatment
Definition
surgical-variocelectomy
Term
Benign prostatic hyperplasia treatment
Definition
surgical TURP (trans urethral resection of prostate) or urethral stents
Term
Testicular cancer treatment
Definition
surgical removal of testicle (orchidectomy), radiation, chemotherapy
Term
Herald patch
Definition
pityriasis rosea: acute self-limited eruption in young adults and adolesents; begins as oval scaly lesion called “Herald patch” within week multiple pale-red oval patches with fine scale around periphery appear on neck, trunk, proximal extremities (exposure to sunlight results in faster disappearance of lesions)
Term
Onychomycosis
Definition
nail fungus that cause the nail to become thick or ragged and appear yellow, green brown, or black in color; an infected nail may even separate from the nail bed. Treatments are available but take a long time to work
Term
Seborrheic keratosis
Definition
brown papules and nodules (wart like growth) have stick on appearance, (don’t turn malignant, don’t need to be removed unless cosmetically desired or irritating)
Term
Actinic keratosis
Definition
erythematous, scaly, rough lesion caused by chronic exposure to sunlight (premalignant growth, can develop into squamous cell carcinoma)
Term
Melanoma
Definition
deadliest of skin caner
3% of skin malignancies, but responsible for almost all deaths due to skin cancer
Invade deeper layers of dermis and subcutaneous tissues and metastasize to distant sites
Increased incidence w/ greate sun exposure
Diagnosis is based on change in shape, color, size and configuration of pigmented lesion
Clinical manifestations:
Asymmetry of lesion
Border irregularity
Color variegation
Diameter greater than 6 mm (pencil eraser)
Treatment:
Early detection
Aggressive surgical removal
Term
Dermatitis vs eczema
Definition
same thing!
Term
Acute eczema
Definition
vesicles bulliae erythema, weeping, crusting
Term
Chronic eczema
Definition
thickened, scaly, pruritic patches and plaques
Term
Eczema/Allergic Contact Dermatitis
Definition
all types of red, blistering, weeping, scaly, thickened, itchy skin lesions
Term
Junctional Nevi
Definition
not palpable, uniformly brown, small macules, round in shape and smooth regular borders (good, not suspicious)
Term
Compound Nevi
Definition
palpable, uniformly pigmented, elevated (not suspicious)
Term
Blue Nevus
Definition
irregular borders, blue-black in color, must rule out melanoma; if lesion is present for years, biopsy not necessary, if new must biopsy (color suspicious, irregular shape)
Term
Compound Nevi with Halo
Definition
nevus may disappear in time leaving only white macular portion (not suspicious)
Term
Giant Congenital Nevus
Definition
chocolate brown hairless plaque with smudged border in newborn, usually become elevated and hairy with age (can develop malignant melanoma, surgical excision will take multiple surgeries)
Term
Dysplastic Nevus
Definition
variegated brown macule w/ slightly rased area at 1000, fuzzy margins, oval shape (precancerous)
Term
Acne vulgaris
Definition
acute or chonic inflammatory process of sebaceous glands (oil glands); mechanical factors cause rubbing, friction, pressure or stretching of skin rich in oil glands such as football helmets, surgical tape, shirt collars also oil-based cosmetics, medications, dietary changes; acutane used in antibiotic resistant cystic acne
Term
Acne Rosacea
Definition
have increased number of sevacious glands with multiple small telangiectases
Usually in thos 40-60 years old
Pronounced erythema, superficial pustules and papules over cheeks
Avoid excessive amounts of alcohol and spicy foods
Treat with tetracycline
Term
Basal cell carcinoma
Definition
most common malignant tumor of skin, caused by exposure to sunlight, radiologic therapy, contact with arsenic, rare genetic disorders
Erythematous, smooth pearly nodule, usually elevated may have telangiectatic vessels
Frequently see central ulceration and bleeding
Term
Squamous cell carcinoma
Definition
ulcerated, scaly, thickened nodule that bleeds occasionally, may be surrounded by multiple actinic keratosis
Can be indistinguishable from eczema or psoriasis
Causes: sunlight, ingestion of arsenic, radiologic therapy, burns, scars, genetic susceptibility
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