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Pathophysiology CH 34
patho quiz 1
53
Nursing
Graduate
07/07/2013

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Term
neuron
cell body
Definition
controls cell activity
Term
neuron
dendrites
Definition
conduct information toward the cell body
Term
neuron
axon
Definition
carries impulses away from cell body
Term
supporting cells
Definition
PNS - Schwann cells
CNS - oligodendrocytes, astrocytes (astroglia), microglia, ependymal
Term
Schwann cells
Definition
produce the myelin sheath = rapid conduction of nerve impulses
Term
oligodendrocytes
Definition
form the myelin (multilayered around several axon = increase velocity of nerve conduction
Term
astrocytes/ astroglia
Definition
largest and most numerous - form network, facilitate communication, involved with scar tissue in the brain (gliosis)
Term
microglia
Definition
small, phagocytic - clean up debris
Term
ependymal cell
Definition
lining of neural tube cavity, ventricular system (choroid plexus - production of CSF)
Term
nervous tissue metabolic requirement
Definition
15% of resting cardiac output
20% of it's oxygen
Term
functional importance of ion channels
Definition
they change the polarity of the cell - stimulating the action potentials (communication between neurons)
Term
phases of action potential
Definition
resting membrane potential (-90mV)
depolarization (+30 to +45mV)
repolarization
Term
threshold potential
Definition
-60mV; when reached opens ion channels (all or nothing, fully open or fully closed)
Term
resting membrane potential
Definition
-90mV; polarized (pos in/ neg out of cell) but no electrical activity - not transmitting impulses
Term
depolarization
Definition
+30 to +45mV; sodium channels open = rapid inflow of sodium ions that generate the electrical impulse
Term
repolarization
Definition
close sodium channels, open potassium channels = efflux of potassium and return of resting membrane potential
Term
synapses
Definition
structures that permit communication between neurons
Term
electrical synapses
Definition
consist of gap junctions between adjacent cells that allow action potentials to move rapidly from one cell to another
Term
chemical synapses
Definition
involve special presynaptic and postsynaptic structures, separated by a synaptic cleft. They rely on chemical messengers - released from presynaptic neuron - cross synaptic cleft - interact with receptors of postsynaptic neuron
Term
neurotransmitters
Definition
chemical messengers that control neural function; they interact with cell membrane receptors to selectively cause excitation or inhibition of action potentials
Term
3 major types of neurotransmitters
Definition
amino acids (glutamic acid and GABA)
peptides (endorphins and enkephalins)
monoamines (epinephrine and norepinephrine)
Term
neuromodulators
Definition
chemical messengers that react with membrane receptors to produce slower and longer-acting changes in membrane permeability
Term
neutrotrophic factors
Definition
growth factors - released from presynaptic terminals - required to maintain the long-term survival of postsynaptic neurons
Term
hierarchy of control
Definition
forebrain controls the brain stem, the brain stem controls the spinal cord
Term
archilayer
Definition
connects neighboring segments
contains neurons - reticular activating system
reticular formation
Term
RAS
Definition
reticular activating system
responsible for regulating arousal and sleep wake transitions
Term
reticular formation
Definition
site of many important spinal cord and brain stem reflex circuits
Term
paleolayer
Definition
fibers reach to the brain stem
longitudinal communication between more distant segments of nervous system; track systems for sensation and movement
Term
neolayer
Definition
pathways for bladder control and fine motor skills
develop by fifth year of life
become functional in infancy and childhood, very delicate and discriminate function
Term
hindbrain
Definition
medulla oblongata, cerebellum, and pons
gives rise to cranial nerves V-XII controlling viscera, hearing, facial, and mouth/throat functions
aka brain stem
Term
midbrain
Definition
cerebral peduncles, cerebral aquaduct, superior colliculi, inferior colliculi
gives rise to cranial nerves III and IV controlling eye movement
Term
forebrain
Definition
thalamus, hypothalamus, cerebrum
gives rise to cranial nerves I and II for smell and sight
Term
functions of the hindbrain
Definition
reflex centers for heart and respiration rates, coughing swallowing, vomiting, etc.
cerebellum allows fine motor coordination
Term
functions of the midbrain
Definition
cerebral peduncles carry nerve fibers from the cerebrum to the hindbrain
cerebral aqueduct lets CSF drain from the 4th ventricle inside the cerebrum
superior colliculi control reflex eye movements
inferior colliculi control reflex reactions to sound
Term
functions of the forebrain
Definition
thalamus "switchboard" or relay station for impulses going to and coming from the cerebrum
hypothalamus homeostatic control
Term
cerebrum
Definition
frontal lobe: motor, anticipation
parietal lobe: somatosensory
temporal lobe: hearing, memory
occipital lobe: vision
limbic system: emotional
Term
dura mater
Definition
2 layers
inner layer separates the cerebral hemispheres
venous blood drains out of the brain in a sinus
bridging veins carry blood from the brain across the inner layer of the dura mater to the sinus
sinus also collects CSF
Term
arachnoid
Definition
lies just beneath dura mater
waterproof
CSF lies under arachnoid to cushion the brain
villi (extensions of arachnoid) poke through the inner layer of the dura mater into the sinuses to let CSF drain into the sinuses
Term
pia mater
Definition
lies right on the surface of the brain
holds the cerebral arteries in place
Term
meninges (system of membranes the envelope the CNS) and meningeal spaces
Definition
epidural space: meningeal arteries
dura mater: subdural space: bridging veins
arachnoid: subarachnoid space: cerebral arteries, CSF
pia mater
Term
function of meninges
Definition
protect CNS
Term
CSF
Definition
leaks out of capillaries inside the brain's hollow ventricles (composition controlled by the blood-brain barrier) - passes out an opening below the cerebellum - circulates around the brain and spinal cord in the subarachnoid space - passes through arachnoid villi into blood in the dural sinuses and is returned to the heart
Term
ANS:
sympathetic
Definition
catecholamines
epinephrine, norepinephrine, dopamine
attach to adrenergic receptors
Term
Autonomic Nervous System
Definition
sympathetic
parasympathetic
Term
ANS:
parasympathetic
Definition
acetylcholine
attaches to cholinergic receptors
Term
neurotransmitters for sympathetic postganglionic neurons
Definition
norepinephrine and epinephrine
Term
acetylcholine
Definition
neurotransmitter for
sympathetic: preganglionic
parasympathetic: preganglionic and postganglionic
Term
adrenergic neurotransmitters
Definition
synthesized in the sympathetic system
attach to adrenergic receptors
neurotransmitter is removed from synapse by reuptake or degraded by enzymes
Term
adrenergic receptors
Definition
alpha 1: constrict blood vessels
alpha 2: negative feedback to stop neurotransmitter release
beta 1: speed and strengthen heart
beta 2: bronchodilation
Term
cholinergic neurotransmitter - acetylcholine
Definition
released from parasympathetic system from motor neurons
attaches to cholinergic receptors
neurotransmitter is removed from the synapse by acetylcholinesterase
Term
cholinergic receptors
Definition
nicotinic: excite skeletal muscle cells
muscarinic: slow heart, stimulate GI tract, vasodilate
Term
dorsal
Definition
afferent (to CNS)
sensory
Term
ventral
Definition
efferent (away from CNS)
motor
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