Term
|
Definition
|
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Term
|
Definition
|
|
Term
| what does c3a and c5a do together and separately? |
|
Definition
| both: increase permeability and dilation, c5a also initiates AA metabolism. |
|
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Term
|
Definition
| increase vascular permeability, wbc adherence, and fibroblasts. |
|
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Term
| name the two AA metabolites. |
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Definition
| lipoxygenase (leukotrienes) and COX (thromboxane and prostaglandin) |
|
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Term
| what do the metabolites of AA in the cycloxygenase pathway do? |
|
Definition
thromboxane: increase vasoconstriction and platelet aggregation
prostaglandin: increase vascular permeability and vasodilation. |
|
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Term
| what is one cell that sequesters histamine? |
|
Definition
|
|
Term
| what do leukotriene c, d, and e4 do? |
|
Definition
| stimulate smooth muscle contraction, increase vascular permeability, involved in allergies. |
|
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Term
| what promotes interleuken secretion? |
|
Definition
| endotoxins or physical injury |
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Term
|
Definition
| induce the synthesis of adhesion molecules, nitric oxide synthesis, aggregation of neutrophils, systemic acute phase rxn. |
|
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Term
| what makes the adhesion molecules? |
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Definition
|
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Term
| where does autocrine bind? paracrine? endocrine? |
|
Definition
| surface; neighbor; travels |
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Term
|
Definition
| endothelial cells and macrophages |
|
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Term
| what is platelet activating factor made by? |
|
Definition
|
|
Term
|
Definition
| increase permeability/vasodilation, platelet aggregation, AA metabolism, leukocyte adherence |
|
|
Term
| what do neutophils release? |
|
Definition
| paf, leukotrienes, prostaglandins, lysosomal enzymes. |
|
|
Term
| what do b lymphocytes secrete? |
|
Definition
|
|
Term
| what do macrophages release? |
|
Definition
| paf, leukotrienes, prostaglandins, cytokines, lysosomal enzymes |
|
|
Term
| what do macrophages release? |
|
Definition
| paf, leukotrienes, prostaglandins, cytokines, lysosomal enzymes |
|
|
Term
| what activates macrophages? |
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
| what is the first type of Ig produced in infection response? |
|
Definition
|
|
Term
| describe type I hypersensitivity. |
|
Definition
| allergy! IgE! binds to mast cells, histamine released. |
|
|
Term
| describe type II hypersensitivity. |
|
Definition
| cytotoxic. IgG and IgM bind to FIXED antigens. triggers MAC attack. |
|
|
Term
| example of type II hypersensitivity? |
|
Definition
| myasthenia gravis, graves disease |
|
|
Term
| describe type III hypersensitivity. |
|
Definition
| immune complex mediated. IgG and IgM bind to CIRCULATING antigens. makes huge meshwork and deposits in tissues. |
|
|
Term
| examples of type III hypersensitivity? |
|
Definition
| injection site redness, systemic=lupus, bvs=vascular disease, jt space=artritis. |
|
|
Term
| describe type IV hypersensitivity. |
|
Definition
| t-cell mediated/delayed type. DOESN'T REQUIRE ANTIBODY! response delayed 24-48 hours. need 2 exposures. |
|
|
Term
| granulomatous inflammation=? |
|
Definition
| giant cells and epitheliod cells. |
|
|
Term
| name the morphologic patterns of inflammation. |
|
Definition
| serous, fibrinous, suppurative, ulcerative. |
|
|
Term
| Name and describe the four steps of scar formation. |
|
Definition
| 1. angiogenesis: migration and proliferation of endothelial cells. 2. fibroblast migration 3. ECM deposition. 4. CT remodelling. |
|
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Term
|
Definition
| beginning of scar. made of capillaries, fibroblasts, ec fluid, macrophages. |
|
|
Term
| function of granulation tissue? |
|
Definition
| fill in gaps, remove dead cells, aid in wound contraction, pre-scar. |
|
|
Term
| what is primary wound healing? |
|
Definition
|
|
Term
| what is secondary wound healing? |
|
Definition
| longer inflammation, more granulation, pronounced scar. |
|
|
Term
| what are some complications of wound healing? |
|
Definition
| proud flesh, keloid formation, wound dehiscence, contracture |
|
|
Term
|
Definition
|
|
Term
| what is wound dehiscence? |
|
Definition
|
|
Term
| what happens in contracture? |
|
Definition
| excess wound contraction. myofibroblasts work too well. |
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