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Pathophys Part 3 GI
Alterations of Digestive Function
125
Health Care
Not Applicable
06/15/2012

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Term
Dysphagia is difficulty swallowing caused by
Definition
Esophageal obstruction, tumors, strictures, diverticula, impaired esophageal motility, neural dysfunction, muscular disease and CVA
Term
Dysphagia manifestations are
Definition
distention and spasm of esophagus after swallowing, regurgitation of undigested food
Term
GERD or Gastroesophageal reflux occurs when chyme regurgitates into the esophagus and is due to
Definition
increased abdominal pressure, ulcers, pyloric edema, strictures and hiatal hernia
Term
GERD manifestations are
Definition
regurgitation of chyme within 1 hour of eating; acid reflux, asthma, chronic cough
Term
Hiatal hernia is a protrusion of upper stomach into the thorax and is caused by
Definition
a congenitally short esophagus, trauma, weak diaphragmatic muscles at the GE junction, increased abdominal pressure
Term
Hiatal hernia manifestation are
Definition
GERD, dysphasia, epigastric pain
Term
Pyloric obstruction or narrow pylorus is caused by
Definition
peptic ulcer or carcinoma near pylorus
Term
Pyloric obstruction manifestations are
Definition
epigastric fullness, nausea, pain and vomitus without bile
Term
Intestinal obstruction or impaired chyme flow through the intestinal lumen is caused by
Definition
Hernia, intussusception or telescoping of one prt of the intesting into another, twisting or torsion, inflamed diverticula, tumor growth, loss or peristaltic activity or paralytic ileus
Term
Intestinal obstruction manifestations are
Definition
Colicky pain to severe/constant pain; vomiting, diarrhea, constipation, dehydration, perforation peritonitis and hypokalemia and acidosis with complications
Term
Acute gastrointestinal bleeding is commonly associated with
Definition
hematemesis - bright /brown flood in vomitus; hematochezie - bright red frank rectal bleeding; or melena - dark,tarry stools.
Term
Occult bleeding is slow, chronic blood loss caused by
Definition
iron deficiency anemia because stored iron in the bone marrow is exhausted
Term
Occult bleeding is diagnosed by
Definition
testing for trace amounts of blood in normal appearing stools.
Term
Upper GI bleeding is likely caused by bleeding ulcers in the
Definition
esophagus, stomach or duodemun
Term
Bleeding from the lower GI tract or jejunum, ileum, colon or rectum is likely caused by
Definition
polyps, inflammatory disease, cancer or hemorrhoids
Term
Acute severe GI Hemorrhage is
Definition
a life threatening condition with mortality depending on severity of volume and rate, age,other diseases and efficacy of treatment
Term
Acute attacks of GERD with pain in mid-chest and middle abdomen can be confused with
Definition
Acute MI
Term
Barrett's Esophagus is caused by
Definition
intestinal metaplasia
Term
Barrett's Esophagus is often associated with
Definition
GERD
Term
Barrett's esophagus can develop into
Definition
a rare and deadly esophagael cancer
Term
Intestinal metaplasia is
Definition
the tissue lining the esophagus becomes replaced by tissue similar to the lining of the intestine
Term
Gastritis is
Definition
inflammation of the mucous membrane layer of the stomach
Term
Acute or Chronic Gastritis can affect the
Definition
fundus or antrum or both
Term
Acute gastritis symptoms include
Definition
vague abdominal discomfort, epigastric tenderness and bleeding
Term
Acute gastritis may be caused by
Definition
H. Pylori
Term
Chronic gastritis occurs primarily in the elderly and is caused by
Definition
a progressive thinning and degeneration in the wall of the stomach
Term
There are 2 types of chronic gastritis
Definition
fundal and antral
Term
Chronic fundal gastritis is
Definition
the most severe type and pernicious anemia develops due to intrinsic factor unavailable to facilitate absorption of Vit B12
Term
Chronic fundal gastritis is also known as
Definition
atrophic gastritis
Term
Chronic antral gastritis is
Definition
the most common type with H.Pylori being a major cause; occurs four time more often than fundal gastritis
Term
Peptic ulcer is an ulceration or tear in the protective lining of
Definition
the lower esophagus, stomach or duodenum
Term
Duodenal Ulcers manifestation are
Definition
occur at age 25-50; due to increased acid production; alcohol, tobacco, H.Pylori; pain-food relief, common nocturnal pain; bleeding is common; malignancy is rare
Term
Gastric ulcer manifestations are
Definition
occur at age 59-70 years due to increased stress, normal to low acid production; mod use of alcohol and tobacco; gastritis is common; H.Pylori mayh be present; pain-food-relief; uncommon nocturnal pain, chronic, no remission; exacerbation; bleeding is less common and malignancy is possible
Term
Stress ulcers manifestations are
Definition
related to severe stress, trauma, sepsis, head injuries; increased acid production; pain is asymptomatic until bleeding or performation occurs; bleeding is very common and the most frequent complication
Term
Ulcers that extend through the muscularis mucosae and damage blood vessels are called
Definition
True Ulcers - which can hemorrhage or perforated the wall. Risk factors include smoking, H.Pylori and habitual use of NSAIDS or alcohol
Term
Ulcers in ICD-10 are coded to the specific site when documented; peptic ulcers unspecified are coded to
Definition
a nonspecific category
Term
ICD-10 includes ulcer codes for acute and chronic; hemorrhage / perforation or both for what specific sites
Definition
gastric duodenal peptic and gastrojejunal
Term
Crohn disease or regional enteritis may affect
Definition
any part of the GI tract from mouth to anus
Term
Crohn disease or regional enteritis may be caused by
Definition
smoking, diet and bacteria
Term
A phenomenon of Crohn disease is that inflammation can be found in some segment of the colon or one side of the colon and not the other creating a pattern called
Definition
skip lesions
Term
Crohn disease manifestations are
Definition
family history, mild to severe abd pain; diarrhea; abd mass; small intestinal malabsorption; steatorrhea; skip lesions or lesions in entire intestinal wall; fistulas/abscesses/ narrowed lumen and possible obstruction
Term
Ulcerative colitis manifestations are
Definition
mild to severe abd pain; diarrhea, bloody stools, increased cancer risk; lesions in mucosal layer of the large intestines
Term
Diverticula are
Definition
outpouchings or herniations of the mucosa through the muscle layers of the colon wall; occurring most frequently in the sigmoid colon
Term
Two types of esophageal cancer are
Definition
squamous cell carcinoma - that begins in flat cells lining the esophagus and adenocarcinoma - that begins in cells that make and release mucus and other fluids
Term
Esophageal cancer manifestations are
Definition
chest pain and dysphagia
Term
Risks for esophageal cancer are
Definition
malnutrition, alcohol, tobacco and chronic reflux
Term
Two types of stomach or gastric cancer are
Definition
squamous cell carcinoma and adenomcarcinoma Cancers that forms in tissues lining the stomach.
Term
Manifestations of stomach cancer are
Definition
anorexia, malaise, weight loss, upper abd pain, vomiting, occult blood, metastasis from stomach
Term
Risks for stomach cancer are
Definition
dietary salty foods, nitrates, nitrosamines, gastric atrophy
Term
This colorectal cancer grows in the ring of the left colon and grows in mass in the right colon. This type of cancer is an
Definition
adenocarcinoma
Term
Risks for colorectal cancer are
Definition
chromosomal deletions, polyps, diverticulitis, ulcerative colitis and low fiber / high fat diets
Term
Colorectal cancer manifestations are
Definition
pain, anemia, bloody stool, mass of right colon and obstruction of left colon, distension and elevated CEA
Term
Name the two types of liver cancer
Definition
hepatocarcinoma and cholangiocarcinoma
Term
Risks for liver cancer are
Definition
HBV, HCV, HDV, cirrhosis, intestinal parasites, alfatoxin,smoking and alcohol consumption
Term
Liver cancer manifestations are
Definition
pain, anorexia, bloating, weight loss, portal hypertension, ascites +/-jaundice, elevated serum proteins and enzymes
Term
Name the two types of Gallbladder cancer
Definition
secondary metastases and adenocarcinoma
Term
Risks for gallbladder cancer are
Definition
cholelithiasis
Term
Gallbladder cancer manifestations are
Definition
steady pain, diarrhea, anorexia, vomiting and +/-jaundice
Term
Pancreatic cancer is the 4th most common cancer death. Name the type of cancer
Definition
adenocarcinoma
Term
Risks for pancreatic cancer are
Definition
chronic pancreatitis, cigarette smoking, alcohol and diabetes in women
Term
Pancreatic cancer manifestations are
Definition
weight loss, weakness, nausea, vomiting, abd pain, depression, +/-jaundice, possible hypoglycemia if an insulin secreting tumor
Term
Obesity refers to excessive body fat with a BMI over 30 and is associated with 3 leading causes of death Name them
Definition
cardiovascular disease
cancer
diabetes mellitus
Term
An imbalance between the amount of energy intake and expenditures is linked to excessive caloric intake in this disease
Definition
Obesity
Term
Obesity is a risk facter for what types of cancer in women
Definition
breast, cervical, endometrial and liver cancer in women
Term
Obese men are at greater risk for these cancers
Definition
prostatis, colon and rectal cancers
Term
Obesity is caused by excess calories or inherent metabolic problems. Name these two classifications
Definition
Exogenous - excess ingestion of calories
Endogenous - inherent metabolic problems
Term
Anorexia nervosa is
Definition
refusal to eat beacaus of a distorted body image perception that one is too fat
Term
Bulimia is
Definition
binging or consumption of normal to large amounts of food followed by self induced vmoting or purging of the intestines with laxatives
Term
Marasmus can lead to death due to
Definition
absolute deprivation of food
Term
Marasmus is also called
Definition
protein energy malnutrition
Term
kwashiorkor can result in electrolyte imbalance, loss of renal, pulmonary and cardic functions due to
Definition
carbohydrate intake without protein intake
Term
Diverticulosis is
Definition
an asymptomatic diverticular disease
Term
Diverticulitis is
Definition
a symptomatic inflammation of the colon most frequently seen in the sigmoid colon
Term
Portal hypertension is a complication of liver disease caused by
Definition
obstructive or impeded blood flow in the portal venous system or vena cava; cirrhosis, viral hepatitis, parasite infection, hepatic vein thrombosis, right side heart failure
Term
Portal hypertension manifestations are
Definition
esophageal and stomach varices with vomiting of blood, splenomegaly, ascites
Term
Ascites is a complication of liver disease caused by
Definition
portal hypertension; reduced serum albumin levels, increase capillary hydrostatic pressure which pushes water into the peritoneal cavity, cirrhosis, heart failure, constrictive pericarditis, abdominal malignancies, nephrotic syndrome and malnutrition
Term
Hepatic encephalopathy is a complication of liver disease and is caused by
Definition
blood containing toxins such as annomia are shunted from GI tract to systemic circulation allowing toxins to reach the brain
Term
Hepatic encephalopathy manifestations are
Definition
subtle changes in cerebral function, confusion, tremor of hands, stupor, convulsions and coma
Term
Hemolytic Jaundice or unconjugated bilirubin is a complication of liver disease and is caused by
Definition
excessive hemolysis of RBC because of immune reactions, infections, toxic substances or transfusion of incompatible blood
Term
Obstructive Jaundice or conjugated bilirubin is a complication of liver disease and is caused by
Definition
obstruction of bile flow by gallstones or tumor preventing flow into duodenum or due to drugs
Term
Hepatocellular Jaundice or conjugated and unconjugated bilirubin is a complication of liver disease caused by
Definition
Intrahepatic disease, obstruction by bile calculi, genetic enzyme defects and infections
Term
Hepatorenal syndrome is a complication of liver disease caused by
Definition
a decrease in blood volume, intra vasoconstriction because the liver may fail to remove excessive vasoactive substances from the blood
Term
Hepatorenal syndromes manifestations are
Definition
oliguria, jaundice, ascites, GI bleeding
Term
Viral Hepatitis A has a 30d incubation period and is mild disease. Prevented by hygiene and immune serum globulin. Hep A transmitted via
Definition
fecal-oral, parenteral or sexual pathways
Term
Viral Hepatitis B haas a 60-180d incubation period. Is a severe or prolonged disease; can be chronic, remain a carrier; Prevented by hygiene and HBV vaccine. Hep B is transmitted via
Definition
parenteral or sexual pathways
Term
Viral Hepatitis D has a 30-180d incubation period; Is a severe disease; can be chronic, remain a carrier; Prevented by hygiene and HBV vaccine. Hep D is transmitted via
Definition
parenteral, fecal-oral or sexual pathways
Term
Viral Hepatitis C has a 35-60d incubation period; level of severity is unknown; is a chronic disease; remains a carrier; Prevented by hygiene and screeing of blood; Hep C is transmitted via
Definition
parenteral pathways
Term
Viral Hepatitis E has a 15-60d incubation period; is severe disease in pregnant women; is not chronic and no carrier state; Prevention is by hygiene, safe water; Hep E is transmitted via
Definition
fecal-oral pathways
Term
Viral Hepatitis G is transmitted via
Definition
parenteral and sexual pathways.
Term
The clinical manifestation of the different types of Hepatitis are similar and consist of three phases. Name the phases
Definition
prodromal, icteric and recovery
Term
Prodromal phase of hepatitis is
Definition
the disease process beings about 2 weeks after exposure and ends with appearance of jaundice
Term
Icteric phase of hepatitis is
Definition
the disease process begins about 1-2 weeks after prodromal phase and lasts 2-6 weeks
Term
Recovery phase of hepatitis is
Definition
the jaundice begins to resolve at about 6-8 weeks after exposure. In most cases, liver function returns to normal within 2-12 weeks after the onset of jaundice
Term
Fulminant hepatitis is a clinical syndrome and can be a complication of Hep B or Hep C. Fulminant hepatitis results from
Definition
severe impairment or necrosis of liver cells and potentital liver failure
Term
Cirrhosis is an irreversible inflammatory disease disrupting liver structure and function. Obstruction caused by cirrhosis can cause portal hypertion. Name the causes of Cirrhosis
Definition
alcoholism and complications of Hep A or Hep B
Term
The toxic effects of chronic/excessive alcohol intake cause the liver to oxidize the alcohol into Acetaldehyde which damages hepatocytes; manifesting in hepatomegaly, splenmegaly, jaundice, ascites and decreased sexual function. Nam this form of cirrhosis
Definition
Alcoholic cirrhosis
Term
The cause of this cirrhosis is unknown but is possibly due to an autoimmune mechanism that scars ducts and manifesting in hepatomegaly, splenomegaly, jaundice, ascites and circulating IgG. Name this form of cirrhosis
Definition
Primary biliary cirrhosis
Term
The cause of this cirrhosis is obstruction by neoplasms, strictures or gallstones, scars the ducts proximally and manifesting in hepatomegaly, splenmegaly, jaundice, ascites; Name this form of cirrhosis
Definition
Secondary biliary cirrhosis
Term
The cause of this cirrhosis is viral hepatitis due Hep C, drugs or other toxins, consequence of chronic and severe liver disease; manifesting in hepatomegaly, splenomegaly, jaundice, ascites and liver is small/distorted. Name this form of cirrhosis
Definition
Post-necrotic cirrhosis
Term
Gallstone formation is cholelithiasis and inflammation of the GB or cystic duct is cholecystitis. There are 2 types of gallstones - name them
Definition
Cholesterol and Pigmented
Term
Cholesterol gallstones most common and are formed
Definition
in the bile that is supersaturated with cholesterol produced by the liver
Term
Pigmented gallstones are defined as
Definition
occuring later in life and associated with cirrhosis
Term
Cholecystitis is
Definition
an acute or chronic GB disease almost always caused by the lodging of a gallstone in the cystic duct
Term
The preferred treatment for gallstones causing obstruction or inflammation is
Definition
Lap cholecystectomy
Term
Right Upper Quadrant pain and an intolerance to fatty food are manifestations of
Definition
Cholecystitis
Term
Pacreatitis is
Definition
relatively rare but a potentially serious disorder due to inflammation of the pancreas
Term
Acute pancreatitis is
Definition
due to an injury or disruption of the pancreatic ducts or acini
Term
Chronic pancreatitis is due to
Definition
alcohol abuse
Term
Acute pancreatitis manfestations are
Definition
mild to severe epigastric or mid abd pain
Term
Cleft Lip in children is
Definition
incomplete fusion of nasomedial or intermaxillary process occuring in the 2nd month of embryonic development and occurs in 1/600 births
Term
Cleft palate is
Definition
a defect that may affect only the uvula and soft palate but may extend forward toward the nostrils through the hard palate; frequently is associated with cleft lip
Term
Esophageal atresia in children is
Definition
congenital condition where the esophagus ends in a blind pouch and may be accompanied by a connection between the esophagus and trachea called tracheoesophageal fistula (TEF)
Term
Pyloric stenosis in children is
Definition
obstruction of the pylorus due to hypertrophy of the pyloric sphincter; obstructin is evident between 1-2 weeks and 3-4 months of age. Most common in boys
Term
Pyloric stenosis manifestations are
Definition
marked projectile vomiting at 2-3 weeks of age that does not resolve; weight loss, electrolyte imbalances and dehydration
Term
Intestinal secretions and amniotic fluid that fills the entire intestine before birth is called
Definition
meconium
Term
Intestinal obstruction caused by the meconium of the newborn is
Definition
meconium ileus
Term
Congenital condition assocated with the failure of the parasympathetic nervous system to produce intramural ganglion cells in the enteric nerve plexes is
Definition
Congenital aganglionic megacolon or Hirschsprung disease
Term
One third of all intestinal obstructions in infants, occuring in 1/5000 births is
Definition
Hirschspring disease
Term
The telescoping or invagination of one portion of intestine into another, causing intestinal obstruction and most common in the ileum is called
Definition
intussusception
Term
GER in children has been implicated as a possible factor in SIDS; GER is more common in premature newborns and resolves by 6-12 months. GER is due to
Definition
the return of gastric contents into the esophagus because of poor function of the lower esophageal sphincter in newborns
Term
A childrens multisystem disease primarily manifesting in the pancreas resulting in pancreatic insufficiency in 85% of children is called
Definition
Cystic fibrosis (CF)
Term
A loss of mature villous epithelium caused by the ingestion of gluten is called
Definition
Celiac sprue, celiac disease and now called Gluten-sensitive enteropathy
Term
Individuals with gluten sensitive enteropathy follow strict diets as the
Definition
gluten is toxic to the intestinal epithelial cells
Term
In ICD-10 cleft lip is classified as
Definition
bilateral, unilateral, partial or complete
Term
In ICD-10, cleft palate is classified as
Definition
hard or soft, bilateral, unilateral, partial or complete
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