Shared Flashcard Set

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Pathology
2.3 Medical Microbiology
44
Other
Not Applicable
10/02/2007

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Cards

Term
What would call the macrophage, or Antigen presenting cell of the cornea?
Definition
Langerhans cell
Term
What is the most common natureal flora of the eyelid?
Definition
Staph Epidermis
Term
What is the major difference in the cell wall that causes the gram positive bacteria to stain purple?
Definition
the thick peptidoglycan layer
Term
What process results from capillary dilation and immune cells being directed to the infection site?
Definition
inflammation
Term
What is the body trying to accomplish by the inflammation process?
Definition
contain the infection to the site of entry
Term
What does the period of convalesence refer to in the clinical course of infection?
Definition
The patient being sick for a while
Term
What is the term for a pathogen growing massively within the host?
Definition
septicemia
Term
What do you call a site where mucus membranes meet the skin?
Definition
portal of entry
Term
What do the sweat glands use a mixture of that inhibits many microbes on the skin?
Definition
salt and fatty acids
Term
How do the normal flora suppress potential pathogen growth?
Definition
competition for nutrients
Term
Why do pathogens in the small intestine have little to feed on in the small intestine despite the abundance of nutrients present?
Definition
the effiency of the adsorption system
Term
Why do the bacteria of the large intestine rarely do us harm?
Definition
A protective mucous layer separates the contents of the large intestine from the large intestines cells
Term
What percent of the feces are bacteria by weight?
Definition
40%
Term
What is the bodies main defense against cytoplasmic bugs?
Definition
cytotoxic T cells
NK cells
T cell dependent macrophage activation
Term
What is the bodies main defense against vesicular pathogens?
Definition
T cell and NK cell depedent macrophage activation
Term
What is the bodies main defense against vesicular pathogens?
Definition
T cell and NK cell depedent macrophage activation
Term
What is the bodies main defense against pathogens in the interstitial spaces?
Definition
Antibodies, complement, phagocytosis, neutralization
Term
What is the bodies main defense against pathogens on the epithelial surface?
Definition
Antibodies (especially vitamin A)
inflammatory cells
Term
What is the bodies main defense against pathogens on the epithelial surface?
Definition
Antibodies (especially vitamin A)
inflammatory cells
Term
What type of cells provide a second line of defense by consuming invaders and secreting cytokines?
Definition
Phagocytes
Term
What do you call a monocyte that leaves the blood and goes into the tissue?
Definition
macrophage
Term
How do phagocytes kill other cells?
Definition
fusion with lysosome-like granules containing, lowered pH, peroxide, and enzymes
Term
What are three antibody mediated defenses or humoral factors?
Definition
BOA

1. Bacteriolytic enzymes-can lyse gram negative bacteris
2. Opsonizing antibodies-coat the cells surface and enhance phagocytosis (Fc receptors)
3. Antitoxins-specific antibodies that bind to certain exotoxins
Term
What are three cell mediated factors?
Definition
1. K and NK cells
2. Cytotoxic T-lymphocytes
3. Activated macrophages
Term
How does the body seal off an area during an inflammation response?
Definition
1. dilation of blood vessels
2. formation of clots
Term
What do you call a normal flora organism that is not pathogenic but becomes pathogenic after it is innoculated in the wrong place or the host becomes weakened and immunocompromised?
Definition
oppurtunistic infection
Term
What is a possible consequence of E coli infection of the urinary tract?
Definition
renal failure
Term
What are the four bacterial virulence factors?
Definition
A TIA
1. adherence
2. invasive factors
3. toxins
4. anti-phagocytic factors
Term
What do you call the hairlike appendages that extend from the bacterial surface that usually allow the bacteria to attach to the mucus membranes?
Definition
pili or fimbriae
Term
What enzyme enables the staphylococcus enzyme to clot plasma and thereby form a sticky coat of fibrin around the bacteria for protection?
Definition
coagulase
Term
What is the most common enzyme associated with invasveness?
Definition
coagulase
Term
What enzyme is also called fibrinolysin? It dissolves the fibrin clot that surrounds a wound. It can be used to treat stroke.
Definition
streptokinase
Term
What enzyme enables the staph, strep,clostridia, or pneumonococi to spread through the connective tissue?
Definition
hyaluronidase
Term
What enzyme is secreted by clostridia and breaks down connective tissue causing gangrene?
Definition
collagenase
Term
What type of toxins are non antigenic, relatively stable and a lipopolysaccharide is released after autolysis? What kind of bacteria release them?
Definition
endotoxins of Gram - bacteria or pseudo
Term
What are the highly secreted toxic proteins that are antigenic and heat labile? What produces them?
Definition
exotoxins, gram + bacteria
Term
What kind of toxins are an integral part of the cell wall of gram - bacteria?
Definition
Endotoxins
Term
Which type of toxins are characterized by the target organ they effect?
Definition
exotoxins
Term
How does botulinum toxin effect the nervous system?
Definition
It stops the vessicles of acetylcholine from being secreted by the presynaptic neuron. Acetylcholine is produced and packaged in vesicles, but the vessicles are never released into the synaptic cleft.
Term
Which type of toxin stimulates the macrophages to release tumor necrosis factor producing fever and shock?
Definition
endotoxin
Term
While the leukocidin enzyme is produced by both staph and strep, the hemolysin is produced only by _____?
Definition
strep
Term
What enzyme produced by clostridium infrengens destroys the cell membrane of red blood cells?
Definition
lecinthase
Term
What bacteria produces coagulase and is hemolytic?
Definition
Staphylococcus Aureus
Term
What do bacteria with capsules require to be phagocytosed?
Definition
antibody binding
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