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Pathology
N/A
5
Medical
Professional
09/28/2011
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Term
Nephrotic Syndrome
 Definition

Heavy Proteinuria ≥ 3.5 gm protein/24 hrs

hypoalvuminemia (plasma albumin <3 gm/dl

generalized edema

hyperlipidemia and lipiduria
Term
Nephrotic Syndrome Pathophysiology
 Definition
increased permeability of glomerular capillary wall to plasma proteins, particularly albumin-->hypoalbuminemia-->loss of colloid osmotic pressure-->edema and hypovolemia-->↓GFR and ↑ADH from pituitary-->↑Na/H2O retention-->↑ edema and anasarca (massive edema)
Term

Selective Proteinuria

 

Nonselective proteinuria

 

Hyperlipidemia and lipiduria

 Definition

1. Low MW proteins:  albumin, transferrin, IgG

 

2.  Low and High MW proteins:  IgM, IgA

 

3.  incresed circulating cholesterol and TG due to hypoalbuminemia trigger incr synthesis by liver, abnormal transport w/ decr. uptake into tissues, impaired breakdown of lipoproteins
Term
Nephrotic Syndrome Causes
 Definition

Minimal Change Disease

Focal segmental glomerulosclerosis

Membranous glomerulonephritis

Membranoproliferative glomerulonephritis

 

Diabetes Mellitus, Amyoidosis, Systemic Lupus

NSAID, Hep B, C, HIV, Neoplasms
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