Shared Flashcard Set

Details

Pathology
Joint Pain
21
Medical
Graduate
11/05/2010

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Cards

Term
Gout
Definition
Acute arthritis from uric acid deposition
Term
Pseudo-gout
Definition
Transient acute arthritis from deposition of calcium pyrophosphate
Term
Pseudo-gout clinical presentation
Definition
• Mostly affects large joints (knee most common)
• Joint swelling, warmth, erythema, pain
Term
Synovial Chrondromatosis
Definition
Benign synovial membrane proliferation and fragmentation into joint
Term
Synovial Chrondromatosis presentation
Definition
• Joint pain with swelling
• Limited ROM
• History of locking
Term
Ganglion Cyst
Definition
Small cyst-like lesions near joint capsule or tendon
Term
Synovial Cyst
Definition
Herniation of synovium through joint capsule or a massively enlarged bursa
Term
Tenosynovial Giant Cell Tumor
Definition
Benign neoplasm of cells resembling synoviocytes infiltrated with macrophages and histiocytic giant cells in synovial linings
Term
Tenosynovial Giant Cell Tumor
Definition
• Localized: one painless mass
• Diffuse: joint swelling and pain and maybe warmth and erythema
Term
Osteoarthritis
Definition
Progressive noninflammatory erosion of articular cartilage (often monoarticular and in joints with no systemic involvement with other organs)
Term
Osteoarthritis etiology
Definition
Most common arthritis
Mostly in elderly
Term
Osteoarthritis clinical
Definition
• Pain and stiffness of joints
• Heberden’s Node, Bouchard’s Node
Term
Suppurative Arthritis
Definition
Arthritis and intra-articular pus formation from bacterial agent
Term
Rheumatoid Arthritis
Definition
Chronic systemic inflammatory disorder that primarily attacks multiple joints, tho it may involve other tissues or organs
Term
RA clinical presentation
Definition
• Variable – flares and remissions
• Fatigue, anorexia, low grade fever, joint aches and stiffness (mostly in morning)
• Flares: swollen, painful, erythematous episodes in multiple joints
• Joint deformities over time
• Felty’s syndrome: neutropenia and enlarges spleen
• Sjogrens syndrome: salivary glands of eyes and mouth inflamed
• Vasculitis: inflammation of vessels
Term
RA etiology
Definition
• Autoimmune disorder from genetic and envir. factors
• In predisposed individuals, exposure to unknown joint antigen -> continuous CD4+ and other lymphocyte activation -> damaged joint
Term
SLE
Definition
Systemic Lupus Erythromatosis (SLE)
Chronic autoimmune disorder affecting any part of body
Term
SLE clinical presentation
Definition
• Variable – flares and remissions
• Fatigue, anorexia, low grade fever, joint aches and stiffness
• Muscle and joint stiffness mostly in morning
• Malar rash, minimally destructive arthritis, anemia, leucopenia, platelepenia, nephritis, other organs
Term
Seronegative Spondyloarthritis
Definition
Group of diseases that develop in genetically predisposed individuals initiated by environmental factors
Commonalities: seronegative for RF or ANA and spondylitis can occur
Term
Ankylosing Spondyloarthritis
Definition
• Type of arthritis that causes chronic inflammation of spine and sacroiliac joints
• 90% of patients are HLA-B27+
• Over time spine fuses and become immobile
• Men 20-30 years of age most susceptible to chronic disease
Term
Reactive arthritis
Definition
• Non-infectious arthritis mostly in limbs and occurs within one month of primary infection localized elsewhere in the body
• Chlamydia, shigella, salmonella, yersinia, campylobacter most common
• Chronic disease similar to ankylosing spandyloarthritis
• 80% patients HLA-B27+
• People 20-30 years
• Goes away in a week
• Reiter Syndrome: arthritis, urethritis, conjunctivitis, and maybe balanitis and spondylitis
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