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PATHOLOGY
PATHOLOGY CHAPTER 3
41
Dentistry
Undergraduate 1
02/27/2014

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Term
ACANTHOLYSIS
Definition
•DISSOLUTION OF THE INTERCELLULAR BRIDGES OF THE PRICKLE CELL LAYER OF THE EPITHELIUM
Term
ACQUIRED IMMUNE RESPONSE
Definition
•IMMUNE RESPONSE TO A FOREIGN SUBSTANCE, BASED ON SPECIFIC MEMORY OF A PAST EXPOSURE TO THAT SAME FOREIGN SUBSTANCE
•THE SECOND ACQUIRED IMMUNE RESPONSE IS QUICKER THAN THE INITIAL RESPONSE
Term
ACTIVE IMMUNITY
Definition
•BASED ON ANTIBODIES DEVELOPED IN RESPONSE TO AN ANTIGEN
•THERE ARE 2 TYPES OF ACTIVE IMMUNITY:
-NATURAL AND ACQUIRED
Term
ALLERGEN
Definition
•ANTIGEN PRODUCING A HYPERSENSITIVITY REACTION
Term
ALLERGY
Definition
•HYPERSENSITIVITY ACQUIRED THROUGH EXPOSURE TO A PARTICULAR ALLERGEN THAT ELICITS AN EXAGGERATED REACTION ON REEXPOSURE TO THE SAME ALLERGEN
Term
ANAPHYLAXIS
Definition
•SEVERE, IMMEDIATE TYPE OF HYPERSENSITIVITY OR ALLERGY IN WHICH AN EXAGGERATED IMMUNOLOGIC REACTION OCCURS ON REEXPOSURE TO A FOREIGN PROTEIN OR OTHER SUBSTANCE AFTER SENSITIZATION
•CAN RESULT IN:
-HIVES
-ITCHING
-SWELLING
-VASCULAR COLLAPSE
-SHOCK
•AKA: ANAPHYLACTIC SHOCK
Term
ANTIBODY
Definition
•PROTEIN MOLECULE (Ig) THAT IS SECRETED BY PLASMA CELLS AND REACTS WITH A SPECIFIC ANTIGEN
•THERE ARE 5 CLASSES OF ANTIBODIES:
-IgA
-IgD
-IgE
-IgG
-IgM
Term
ANTIBODY TITER
Definition
•LEVEL OF SPECIFIC ANTIBODY IN THE BLOOD
Term
ANTIGEN
Definition
•ANY SUBSTANCE ABLE TO INDUCE A SPECIFIC IMMUNE RESPONSE
Term
ATTENUATE
Definition
•TO REDUCE THE SEVERITY OF A DISEASE OR THE VIRULENCE OF A PATHOGENIC AGENT, AS IS DONE IN THE DEVELOPMENT OF CERTAIN VACCINES
Term
AUTOANTIBODY
Definition
•ANTIBODY THAT REACTS AGAINST A NORMAL TISSUE CONSTITUENT OF ONE'S OWN BODY
Term
AUTOIMMUNE DISEASE
Definition
•DISEASE CHARACTERIZED BY TISSUE TRAUMA CAUSED BY AN IMMUNE RESPONSE AGAINST TISSUE CONSTITUENTS OF ONE'S OWN BODY
Term
B-CELL LYMPHOCYTE
Definition
•DEVELOPS IN LYMPHOID TISSUE OTHER THAN THE THYMUS
•CAN LATER DEVELOP INTO A PLASMA CELL THAT PRODUCES ANTIBODY
•MAIN INITIATOR OF HUMORAL IMMUNITY
Term
CELL-MEDIATED IMMUNITY
Definition
•TYPE OF IMMUNITY IN WHICH THE MAJOR ROLE IS PLAYED BY T-CELL LYMPHOCYTES
Term
CYTOKINES
Definition
•PROTEINS PRODUCED BY VARIOUS CELL TYPES FOR THE PURPOSE OF INTERCELLULAR COMMUNICATION
•IMMUNOLOGICAL CYTOKINES ARE INVOLVED IN THE IMMUNE RESPONSE
Term
DENDRITIC CELL
Definition
•WHITE BLOOD CELL THAT ACTS AS AN ANTIGEN-PRESENTING CELL IN THE SKIN AND MUCOSA
Term
HUMORAL IMMUNITY
Definition
•TYPE OF IMMUNITY IN WHICH BOTH B-CELL LYMPHOCYTES AND THE ANTIBODIES THEY PRODUCE AS PLASMA CELLS PLAY THE PREDOMINANT ROLE
Term
HYPOSALIVATION
Definition
•DECREASED SALIVARY FLOW THAT MAY RESULT IN XEROSTOMIA
Term
HYPERSENSITIVITY
Definition
•BODY REACTS TO A FOREIGN AGENT, OR ALLERGEN, WITH AN EXAGGERATED IMMUNE RESPONSE.
THERE ARE 4 TYPES: TYPES 1-4
Term
IMMUNE COMPLEX
Definition
•COMBINATION OF AN ANTIBODY AND ANTIGEN PRODUCING A COMPLEX THAT CAN INITIATE A HYPERSENSITIVITY REACTION
Term
IMMUNIZATION
Definition
•INDUCTION OF ACTIVE IMMUNITY
•PRODUCES A STRONGER, FASTER IMMUNE RESPONSE WHEN EXPOSED TO THAT PARTICULAR DISEASE
•PREVENTS DISEASE DEVELOPMENT
Term
IMMUNODEFICIENCY
Definition
•REDUCED IMMUNE RESPONSE RESULTING FROM HYPOACTIVITY OR DECREASED #s OF LYMPHOID CELLS
Term
IMMUNOGLOBULINS
Definition
•PROTEINS THAT SERVE AS ANTIBODIES DESIGNED TO RESPOND TO A SPECIFIC ANTIGEN
•SECRETED BY PLASMA CELLS
•SURFACE IGs REMAIN ATTACHED TO THE SURFACE OF B CELLS AND FUNCTION AS RECEPTORS
Term
IMMUNOMODULATOR
Definition
•SUBSTANCE THAT ALTERS THE IMMUNE RESPONSE BY AUGMENTING OR REDUCING THE ABILITY OF THE IMMUNE SYSTEM TO PRODUCE ANTIBODIES OR SENSITIZED CELLS THAT RECOGNIZE AND REACT WITH THE ANTIGEN THAT INITIATED THEIR PRODUCTION
Term
LANGERHANS CELL
Definition
•SPECIALIZED DENTRIDIC CELL
•FOUND IN SKIN AND MUCOSA
•INVOLVED IN IMMUNE RESPONSE
Term
LE CELL
Definition
•MATURE NEUTROPHIL WITH A PHAGOCYTIZED
Term
LYMPHOID TISSUE
Definition
•TISSUE COMPOSED OF LYMPHOCYTES SUPPORTED BY A MESHWORK OF CONNECTIVE TISSUE
•INCLUDES TONSILLAR TISSUE, LYMPH NODES AND LYMPHATIC ORGANS
Term
LYPHOKINES
Definition
•CYTOKINES PRODUCED BY B- OR T-CELL LYMPHOCYTES IN CONTACT WITH ANTIGENS
•MEDIATORS IN AN IMMUNE RESPONSE
Term
MACROPHAGE
Definition
•LARGE, TISSUE-BOND MONONUCLEAR PHAGOCYTE DERIVED FROM MONOCYTES CIRCULATING IN THE BLOOD
•CAN BECOME MOBILE WHEN STIMULATED BY INFLAMMATION AND INTERACT WITH LYMPHOCYTES IN AN IMMUNE RESPONSE
Term
MONOKINES
Definition
•CYTOKINES PRODUCED BY MONOCYTES OR MACROPHAGES
•MEDIATORS IN AN IMMUNE RESPONSE
Term
MUCOSITIS
Definition
•MUCOSAL INFLAMMATION DUE TO A DISEASE PROCESS
Term
NATURAL KILLER CELL
Definition
•TYPE OF LYMPHOCYTE THAT IS PART OF THE INITIAL INNATE IMMUNE RESPONSE, WHICH BY UNKNOWN MECHANISMS IS ABLE TO DIRECTLY DESTROY CELLS RECOGNIZED AS FOREIGN
Term
NIKOLSKY SIGN
Definition
•DIAGNOSTIC SIGN WHEREBY THE SUPERFICIAL EPITHELIUM SEPARATES EASILY FROM THE BASAL LAYER ON EXERTION OF FIRM, SLIDING MANUAL PRESSURE WITH THE FINGERS
Term
PASSIVE IMMUNITY
Definition
•TYPE OF IMMUNITY THAT USES ANTIBODIES PRODUCED BY ANOTHER PERSON TO PROTECT AN INDIVIDUAL AGAINST INFECTIOUS DISEASES
•THERE ARE 2 TYPES OF PASSIVE IMMUNITY:
-NATURAL AND ACQUIRED
Term
PLASMA CELL
Definition
•CELL DERIVED FROM FROM B-CELL LYMPHOCYTES THAT PRODUCES ANTIBODIES IN RESPONSE TO THE PRESENCE OF ANTIGEN
Term
PRURITIS
Definition
•ITCHING
Term
RHEUMATOID FACTOR
Definition
•ANTIBODY THAT BINDS TO CERTAIN ANTIBODIES FOUND IN THE SERUM OF PATIENTS WITH RHEUMATOID ARTHRITIS AND CONNECTIVE TISSUE DISEASES SUCH AS SJOGREN SYNDROME
Term
SYNDROME
Definition
•GROUP OF SIGNS AND SYMPTOMS THAT OCCUR TOGETHER
Term
T-CELL LYMPHOCYTE
Definition
•MAINLY RESPONSIBLE FOR INITIATING CELL-MEDIATED IMMUNITY AND MODULATING HUMORAL IMMUNITY
Term
THYMUS
Definition
•ORGAN CONSISTING OF LYMPHOID TISSUE LOCATED HIGH IN THE CHEST
•LARGE IN AN INFANT AND GRADUALLY SHRINKS
Term
XEROSTOMIA
Definition
•DRYNESS OF THE MUCUS MEMBRANES
•USUALLY CAUSED BY HYPOSALIVATION
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