Term
| Definition of acute pancreatitis |
|
Definition
| sudden inflammation of the pancreas |
|
|
Term
| Etiology of acute pancreatitis |
|
Definition
| 80% due to biliary tract disease (gallstones) or alcoholism |
|
|
Term
| Clinical course of acute pancreatitis |
|
Definition
| abdominal pain associated with raised pancreatic enzymes in blood, urine, inflammation and necrosis of pancreatic tissue, severe shows extensive fat necrosis leading to death |
|
|
Term
|
Definition
obstruction of pancreatic duct, enzymes of pancreas (lipases and proteases) auto-
digest pancreas and peripancreatic tissue. Lipases break triglycerides into free fatty acids which then
combine with calcium to create calcium soap. |
|
|
Term
| Definition of chronic pancreatitis |
|
Definition
| progressive destruction of pancreas |
|
|
Term
| Etiology of chronic pancreatitis |
|
Definition
| repeated flare-ups of mild acute pancreatitis |
|
|
Term
| Clinical course of chronic pancreatitis |
|
Definition
| replacement of pancreatic parachyma by fibrous connective tissue |
|
|
Term
| Definition of Cystic Fibrosis |
|
Definition
| genetic disorder of exocrine gland affecting mucous secreting and exocrine sweat glands |
|
|
Term
| Incidence of Cystic Fibrosis |
|
Definition
| 1 in 3200 live births, most common lethal genetic disease that affects white populations |
|
|
Term
| Etiology of Cystic Fibrosis |
|
Definition
| genetic disorder, autosomal recessive |
|
|
Term
| Clinical course of Cystic Fibrosis |
|
Definition
| abnormally thick mucus secretion in pancreatic ducts which leads to cystic dilation and fibrous atrophy of pancreas, obstruction and secondary infection of air passages |
|
|
Term
| Clinical significance of pancreatic cysts |
|
Definition
| Usually benign, only 5-15% are neoplastic |
|
|
Term
| Incidence of carcinoma of pancreatic duct cells |
|
Definition
| 4th leading cause of death in the US |
|
|
Term
| Etiologic factors of carcinoma of pancreatic duct cells |
|
Definition
| inherited and acquired mutations in cancer-associated genes |
|
|
Term
| Clinical course of carcinoma of pancreatic duct cells |
|
Definition
| high mortality rate, usually well advanced a time of presentation, jaundice and palpable gallbladder, pain related to extensive infiltration of posterior abdominal wall and associated nerve fibers |
|
|
Term
|
Definition
chronic disorder of carbohydrate, fat and protein metabolism based on either failure
of adequate insulin production or marked decrease in insulin effectiveness (end-organ insensitivity). |
|
|
Term
|
Definition
| amine precursor uptake and decarboxylation |
|
|
Term
| Incidence of islet cell tumors of the pancreas |
|
Definition
|
|
Term
| Clinical course of islet cell tumors of the pancreas |
|
Definition
| APUD tumors, clinical symptoms mimic conditions, carcinoid tumors, 10% mets to lung |
|
|
