Term
|
Definition
| simplex, CMV, Molluscum contagiosum, HPV (common hand/foot wart) |
|
|
Term
|
Definition
|
|
Term
| Spirochetal skin disorders |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| skin disorder commonly called hives |
|
|
Term
| Causative agents of Urticaria |
|
Definition
| antigen-induced release of vasoactive mediators from mast cells, granules via sensitization with specific IgE antibodies |
|
|
Term
| Clinical features of Urticaria |
|
Definition
| localized degranulation of mast cells, microvascular hyperpermeability and pruritic wheals, type 1 hypersensitivity |
|
|
Term
|
Definition
| refers to pathoglic conditions characterized by red, papulovesicular, oozing and crusted lesions that can become scaling plaques |
|
|
Term
| Causative agents of Eczema |
|
Definition
| allergic contact dermatitis (poison ivy), drug-related dermatitis, photoezcematous dermatitis (UV light), primary irritant dermatitis (repeated trauma), hypersensitivity response |
|
|
Term
| Clinical features of Eczema |
|
Definition
| accumulation of edema fluid witin epidermis, seen in early lesions oeczematous dermatitis |
|
|
Term
| Definition of Erythema multiforme |
|
Definition
| self-limiting disorder in hypersensivity response |
|
|
Term
| Causative agents of Erythema multiforme |
|
Definition
|
|
Term
| Clinical features of Erythema multiforme |
|
Definition
| blisters, target lesions (red macuole or papule with a pale, vescilar or eroded center), symmetric involvement of the extremities, can lead to stevens-johnson syndrome |
|
|
Term
|
Definition
| chronic inflammatory dermoatosis |
|
|
Term
| Causative agents of Psoriasis |
|
Definition
|
|
Term
| Clinical features of Psoriasis: |
|
Definition
| large, erythrematous, scaly, plaques on skin of elbows, knees and lumbrosacral area, and becomes a serious debiliatating disorder |
|
|
Term
| Autoimmune humoral immunity non-infectious inflammatory dermatitis |
|
Definition
| Pemphigus vulgaris: blisters |
|
|
Term
| Autoimmune humoral and cellular immunity non-infectious inflammatory dermatitis |
|
Definition
| Lupus erythematosis: "butterfly" rash; mostly female |
|
|
Term
| Idiopathic non-infectious inflammatory dermatitis |
|
Definition
(1) hyperkeratotic inflammatory reaction to normal injury
2) postulated defective epidermal cell surface receptors with augmented inflammation |
|
|
Term
| Example of idiopathic non-infectious inflammatory dermatitis |
|
Definition
|
|
Term
|
Definition
| common disorder characterized by partial or complete loss of pigment-producing melanocytes within the epidermis |
|
|
Term
| Common theories of pathogenesis of vitiligo |
|
Definition
| (1) autoimmune circulating antibodies against melanocytes due to other autoimmune disorder (2) neurohumoral or (3) self-distruction by toxic intermediates of melanin synthesis |
|
|
Term
|
Definition
| benign collection of melanocytes |
|
|
Term
| Morphologic features of Nevi |
|
Definition
| many clinical and histological types, appear as tan-to-brown, uniformly pigmented, small solid regions of elevated skin with well-defined rounded boarders |
|
|
Term
| Clinical significance of Nevi |
|
Definition
| migrate over time and evenetually “burn out” |
|
|
Term
|
Definition
| - consist of melanocytes (nevus cells) forming well-defined, rounded aggregates of cells at the dermoepidermal junction |
|
|
Term
|
Definition
| nests of nevus cells are present at dermoepidermal junction and in dermis |
|
|
Term
| Dermal nevi (intradermal nevi) |
|
Definition
| nests of nevus cells in dermis without the epidermal component. |
|
|
Term
| General features of dysplastic nevi |
|
Definition
| larger than acquired nevi, numerous, variability in pigment, boarders are irregular in contour |
|
|
Term
| Relationship of dysplastic nevi to malignant melanoma |
|
Definition
| genetic predispotiion indicated an increased risk for development of malignant melanoma in a pre-existing dysplastic nevi or in unaffected skin |
|
|
Term
| Definition of malignant melanoma |
|
Definition
|
|
Term
| Incidence of malignant melanoma |
|
Definition
| lighly pigmented people, 1:75, men |
|
|
Term
| Gross features of malignant melanoma |
|
Definition
| invasion, change in color or size of a pigmented lesion, nodule with vertical growth (mets and angiogenesis) |
|
|
Term
| Clinical course of malignant melanoma |
|
Definition
| radial and vertical growth pattern. 0.75 mm potentially metastatic |
|
|
Term
| Relationship of Nevi to malignant melanoma |
|
Definition
| can develop from a dysplastic nevi |
|
|
Term
| Clinical features of Actinic keratosis |
|
Definition
| build-up of excess keratin, lesions are <1 cm in diameters, tan-brown, red or skin-colored and have rough, sandpaper-like consistency, seen on face, arms or hands |
|
|
Term
| Significance of actinic keratosis |
|
Definition
| precursor to squamous carcinoma due to chronic exposure to sunlight |
|
|
Term
| Incidence of squamous cell carcinoma |
|
Definition
| most common tumor arising on old people |
|
|
Term
| Most common anatomical sites of squamous cell carcinoma |
|
Definition
|
|
Term
| Factors predisposing/associated with squamous cell carcinoma |
|
Definition
| sunlight, industrial carcinogens, chronic ulcers or draining osteomyelitis, old burn scars, ingestion of arsenicals, ionzing radiations, tobacco and betal nut chewing |
|
|
Term
| Gross features of squamous cell carcinoma |
|
Definition
| sharply defined, red, scaling, plaques, invasive lesions are nodular, variable scale, and ulcerative |
|
|
Term
| Clinical course of squamous cell carcinoma |
|
Definition
| less than 2% develop metastases from sun-exposed skin, complete excision for cure, 20-50% develop metas when develop on mucosal surfaces |
|
|
Term
| Incidence of basal cell carcinoma |
|
Definition
| common, incidence rises with immunosuppression |
|
|
Term
| Most common anatomical sites of basal cell carcinoma |
|
Definition
| subject to chronic sun exposure in lighly pigmented people |
|
|
Term
| Factors predisposing/associated with basal cell carcinoma |
|
Definition
| immunosuprresion, inheretied genetic defects |
|
|
Term
| Gross morphology of basal cell carcinoma |
|
Definition
| ulcerate, invade bone, cartiledge, orbit and perineural spaces |
|
|
Term
| Clinical course of basal cell carcinoma |
|
Definition
| locally aggressive, rare mets, invasion |
|
|
Term
|
Definition
T-cell lymphoma involving the skin, with an eczema-like reaction. May become
disseminated to include a leukemic phase, with diffuse scaling skin lesions over much of the body - Sezary syndrome. |
|
|
Term
|
Definition
skin-associated cancer of vascular-type tissues most frequently associated with
AIDS; associated with Herpes simplex 8; may metastasize to regional LNs, lung or GI tract |
|
|
Term
| Which tumor of the skin is common, locally aggressive, but rarely metastasizes? |
|
Definition
|
|
Term
| A 37-year-old male presented with numerous blisters on his scalp, face and in his mouth. Clinical examination revealed crusted areas of inflammation. The surface of these crusted areas could be easily removed by rubbing or scratching. Biopsy examination of one blister showed separation of epithelial cells by edema fluid. Lab tests suggested that this was an autoimmune reaction to skin-binding proteins. Based on this information, his physician determined that he has pemphigus vulgaris and that his prognosis was poor unless he undergoes long-term corticosteroid and immunosuppressive therapy. Do you agree with both the diagnosis and the prognosis? |
|
Definition
|
|
Term
| A 45-year-old woman noticed that she developed tingling and numbness over the palmar surface of her thumb, index, and middle fingers after several hours at her computer workstation doing word processing. Pain in the same area often occured at night as well. On physical examination she had minimal atrophy of muscles of both hands. Which of the following conditions is most likely to account for her symptoms? |
|
Definition
| Localized tenosynovitis (carpal tunnel syndrome) |
|
|
Term
| Because this skin lesion is raised and ulcerated, it is most likely a |
|
Definition
|
|
Term
| This neoplasm of pigment-producing cells is a |
|
Definition
|
|
Term
| This skin biopsy shows green fluorochrome-stained intercellular IgG antibody at the intercellular borders of acantholytic epithelial cells. The presence of such an antibody reaction is consistent with a diagnosis of |
|
Definition
|
|
Term
| vascular-type malignancies most frequently associated with AIDS. They may metastasize to regional lymph nodes, the lung, or GI tract. |
|
Definition
|
|
Term
| described as "target lesions". They are red macules with pale vesicular or eroded centers, symmetrically involve the extremities, and are usually self-limited |
|
Definition
|
|
Term
| Which factor MOST commonly predisposes to neoplastic disorders of the skin? |
|
Definition
|
|
