Term
| General Location of Lymphatic tissue |
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Definition
scattered throughout the body as isolated cells, nonencapsulated collections of cells in mucous
membranes, or encapsulated organs - thymus, lymph nodes, spleen. |
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Term
| General Function of Lymphatic tissue |
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Definition
| defense against foreign materials (antigens). Involves presentation of an antigen by a macrophage to lymphocytes. |
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Term
| List of the cells involved in the immune response |
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Definition
| B lymphs, T lymphs (T cell subsets) and antigen presenting cells (macrophages) |
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Term
| B- Lymphocytes description |
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Definition
derived from bone marrow; when stimulated, undergo proliferation and differentiation to
become plasma cells which make antibody; memory cells. The immune response associated with
production of antibody is known as a HUMORAL immune response. |
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Term
| T- Lymphocytes description |
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Definition
derived from bone marrow, processed in thymus; function in regulating the immune
response by directing the activity of other cells. The immune response associated with T-lymphocyte activity
is known as a CELL-MEDIATED immune response |
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Term
| T Helper Cell description |
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Definition
CD4, secrete lymphokines - substances that enhance immune
response (increase B-cell and macrophage activity). [Lymphocyte destroyed by human immunodeficiency virus (HIV-1).] |
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Term
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Definition
CD8, killer cells - can destroy virus-infected and malignant cells
(require activation by T helper). |
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Term
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Definition
| CD8, thought to inhibit T helper cells (often classified in combination with cytotoxic cells). |
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Term
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Definition
| T helper cells, cytotoxic T cells and suppressor T cells |
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Term
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Definition
- fixed and free phagocytic cells derived from monocytes. Appearance and
names vary - epithelioid macrophages (granulomatous inflammation), dendritic reticulum cells (lymph
nodes), histiocytes, Kupffer cells (liver), microglial cells (brain), Langerhans cells (skin). |
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Term
| Other cells that act as antigen presenting cells |
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Definition
| B lymphocytes, endothelial cells and other cells may act as antigen presenting cells |
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Term
| Causes of Reactive Hyperplasia of lymph nodes |
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Definition
| secondary to antigenic stimulus |
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Term
| clinical symptoms of Reactive Hyperplasia of lymph nodes |
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Definition
| granulomatous inflammation or acute lymphadenitis |
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Term
| architectural changes of Reactive Hyperplasia of lymph nodes |
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Definition
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Term
| causes of atypical hyperplasia of lymph nodes |
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Definition
| reactive hyperplasia, lymphoma, infectious monucleosis, pastvaccine lymphoma or lymphogranuloma verereum |
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Term
| clinical symptoms of atypical hyperplasia of lymph nodes |
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Definition
| histologic change in lymph node |
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Term
| architectural changes of atypical hyperplasia of lymph nodes |
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Definition
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Term
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Definition
| heterogenous group of solid tumors if the lymphoid tissue |
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Term
| General characteristics of malignant lymphoma |
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Definition
| more frequent in adults, immunodeficiency is a risk factor, sometimes casued by a virus, can be hodgkin or non hodgkin |
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Term
| classification of Hodgkin Lymphoma |
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Definition
| proliferation of atypical malignant cells interspersed with infiltrate of various inflammatory cells (lymphs, eosinophils, plasma cells, histiocytes), baed in tissue reaction to R-S cells, more lymphocyte response yields a better prognosis |
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Term
| incidence of Hodgkin Lymphoma |
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Definition
| 9290 new causes in 2013, two peak incidence (20’s and 60’s) |
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Term
| etiology of Hodgkin Lymphoma |
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Definition
| unknown, sometimes viruses (EBV or HTLV) |
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Term
| pathogenesis of Hodgkin Lymphoma |
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Definition
| malignant neoplasm of specialized cells |
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Term
| morphology of Hodgkin Lymphoma |
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Definition
| Reed-Sternberg cell (binucleate containing a single prominent eosinophilic nucleus) |
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Term
| clinical course of Hodgkin Lymphoma |
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Definition
| as disease progresses, normally does in a sequential contiguous fashion (neck, chest, abs) |
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Term
| classification of non-Hodgkin Lymphoma |
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Definition
| FAB classification into low, intermediate or high grade lymphoma based on differentiation |
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Term
| incidence of non-Hodgkin Lymphoma |
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Definition
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Term
| pathogensis of non-Hodgkin Lymphoma |
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Definition
| presents with weight loss and night sweats, malignant neoplasm of lymphoid cells growing as tissue mass |
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Term
| morphology of non-Hodgkin Lymphoma |
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Definition
| presents with weight loss and night sweats, malignant neoplasm of lymphoid cells growing as tissue mass |
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Term
| clinical course of non-Hodgkin Lymphoma |
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Definition
| low grade tumoes (usually follicular small cell) slowly progress and are incurable, high grde tumors (large cell) are rapid by can be cured by chemotherapy |
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Term
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Definition
| a neoplastic proliferation of one cell type that originates in the bone marrow |
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Term
| general characteristics of leukemia |
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Definition
| acute/chronic (immaure/mature cells), caused by unstable genetics in BM due to germ line mutations |
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Term
| classification of leukemia |
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Definition
| chronic or acute (depending on cell type) |
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Term
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Definition
| increasing in last 50 years, 8-10 deaths/100,000, two population peaks (10’s and 60’s), 48610 new cases in 2013 |
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Term
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Definition
| malignant cells from bone marrow proliferate and disseminate into circulation |
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Term
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Definition
| proliferating cells, immature (or mature) cells in peripheral blood smear |
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Term
| clinical course of leukemia |
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Definition
| acute is short term with high risk of death is not treated, and chronic is longer term |
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Term
| Chromosome abnormality found in 90% of the patients with CML |
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Definition
| Philadelphia chromosome translocation (9:22) |
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Term
| incidence of multiple myeloma |
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Definition
| rare, increase risk with age |
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Term
| pathogenesis of multiple myeloma |
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Definition
| neoplastic proliferation of plasma cells in bone marrow |
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Term
| morphology of multiple myeloma |
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Definition
| abnormal plasma cells in bone marrow |
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Term
| clinical course of multiple myeloma |
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Definition
| excessive Ig production, bone pain, fractures, lytic lesions in bones |
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Term
| incidence mycosis fungoides |
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Definition
| uncommon, occurs in older males |
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Term
| pathogenesis mycosis fungoides |
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Definition
| cutaneous proliferation of T cells |
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Term
| morphology mycosis fungoides |
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Definition
| markedly convoluted nucleus (called cerebriform), band like dermal infiltrate of atypical lymphocytes mixed with histiocytes and other inflammatory cells |
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Term
| clinical course of mycosis fungoides |
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Definition
| skin involvement can move to involvement of lymph node, spleen and liver |
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Term
| incidence of hairy cell leukemia |
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Definition
| middle age to elderly people |
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Term
| pathogenesis of hairy cell leukemia |
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Definition
| proliferation of mononuclear cells with finger like projections, infiltrate the bone marrow and spleen and cause hypersplenism |
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Term
| morphology of hairy cell leukemia |
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Definition
| proliferation of mononuclear cells with finger like projections, infiltrate the bone marrow and spleen and cause hypersplenism |
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Term
| clinical course of hairy cell leukemia |
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Definition
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Term
| Etiology of non- Hodgkin Lymphoma |
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Definition
| increasing age, unknown, virsus |
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Term
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Definition
| unstable genetics in the BM due to germ line mutations |
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Term
| General incidence of metastatic tumors to the lymph nodes |
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Definition
| more common than primary malignancies of lymph nodes |
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Term
| clinical significance of metastatic tumors to the lymph nodes |
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Definition
| carcinomas, indicated metastasis and malignancy |
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Term
| A 62-year-old man has had back pain for 4 months. No abnormal findings were noted on physical examination, however his serum globulin was high from a monoclonal gammopathy. A chest radiograph showed no abnormalities of heart or lung fields, but there were several clear areas noted in the vertebral bodies. A sternal bone marrow aspirate was performed and yielded a dark red jelly-like material in the syringe. Which of the following cell types is most likely to be numerous on microscopic examination of this aspirate? |
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Definition
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Term
| Which is the lymphoma with the BEST prognosis |
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Definition
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Term
| Chronic Leukemia has a ________ prognosis than acute leukemia |
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Definition
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Term
| The Philadelphia chromosome has been found in 90% of patients with |
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Definition
| chronic myelogenous leukemia |
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Term
| The Reed-Sternberg cell is characteristic of |
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Definition
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Term
| Which of the following would be a typical response of a lymph node draining an infected area? |
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Definition
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