Term
| incidence of hydatidiform mole |
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Definition
| 1-1.5 per 2000 pregnancies in the US, more common before age of 20 and after 40 |
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|
Term
| pathogenesis of hydatidiform mole. |
|
Definition
| : abnormal fertilization, entire genetic content is supplied by two sperm, yielding diploid cells containing only paternal chromosomes |
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|
Term
| gross features of hydatidiform mole. |
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Definition
| hydrophic swelling, edematous stroma, proliferation of both cytotrophoblasts |
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|
Term
| clinical course of hydatidiform mole. |
|
Definition
| elevation of BHCG in materal blood and absence of fetal heart sounds are typical |
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|
Term
| relationship of HCG levels to hydatidiform mole |
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Definition
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|
Term
| relationship of hydatidiform mole to choriocarcinoma |
|
Definition
| 50% of choriocarcinoma arise from moles |
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Term
| clinical significance of invasive mole (chorioadenoma destruens). |
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Definition
| difficult to remove, chemotherapy |
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|
Term
| definition of invasive mole (chorioadenoma destruens) |
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Definition
| cellular mole that penetrates and may perforate the uterine wall |
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|
Term
| incidence of choriocarcinoma |
|
Definition
| rare in the western hemisphere, 1 per 30,000 pregnanciesi n the US. More common in Africa and asia |
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|
Term
| definition of choriocarcinoma |
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Definition
| aggressive malignant tumor which arises from gestational chorionic epithelium or totipotential cells within the gonads |
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|
Term
| clinical course of choriocarcinoma |
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Definition
| arise from moles or abortion, abnormal conception, bloody, brown discharge + rising BHCG in blood or urine, no uterine enlargement, higher BHCG than mole |
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|
Term
| difference between gestational and nongestational choriocarcinoma |
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Definition
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