Term
| lichen sclerosis definition |
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Definition
| atrophic dystrophy the involves the vulva |
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Term
| incidence of lichen sclerosis |
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Definition
| occurs in all age groups, most commonly affects post menopausal women, small percentage (1-5%) can develop squamous cell carcinoma of the vulva |
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Term
| gross appearance of lichen sclerosis |
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Definition
| Presents clinically as leukoplakia (white patch), patient complains of itching, dryness |
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Term
| clinical significance of lichen sclerosis |
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Definition
| Grossly may mimic carcinoma in situ. Is not considered a premalignant condition |
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Term
| condyloma acuminatum definition |
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Definition
| : genital warts of vulva, more common, papillary and distinctly elevated or somewhat flat and rugose |
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Term
| condyloma acuminatum relationship to HPV |
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Definition
| caused by HPV, koilocytosis, cytopathic change characterized by perinuclear cytoplasmic vacuolization and wrinkled nuclear contours hallmark of HPV, associated with 6 and 11, do not progress to cancer |
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Term
| gross appearance of Paget disease of vulva |
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Definition
| red, scaly, crusted, plaque that mimics the appearance of the inflammatory dermatitis |
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Term
| explain how Paget disease of vulva differs from Paget disease of breast |
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Definition
| : tumor cells of the vulvar disease are usually confined to the skin and skin appendages, rarely with an associated adenocarcinoma of the sweat glands. Paget's Disease of the breast is always associated with an underlying adenocarcinoma of the breast |
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Term
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Definition
| squamous cell carcinoma in situ |
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Term
| incidence of carcinoma of the vulva |
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Definition
| primary carcinoma is generally uncommon (3% of genital cancers in the female); usually occurs in women over age 60. Recent increase in incidence in women 40 to 60 years of age, related to HPV. |
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Term
| clinical signs of carcinoma of the vulva |
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Definition
| whitish patches of epithelial thickening, pigmented, exophytic or ulcerative endophytic tumors, multifocal and warty (HPV) lesions that tend to be squamous cell carcinomas, unifocal and well-differentiated keratinizing squamous cell carcinomas (non-HPV) |
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Term
| course of disease of carcinoma of the vulva |
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Definition
| Carcinoma in situ of the vulva (vulvar intraepithelial neoplasia - VIN), called Bowen's disease, clinically appears as leukoplakia. |
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Term
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Definition
| The most frequent type of primary carcinoma is squamous carcinoma (90%) |
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Term
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Definition
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Term
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Definition
| can be HPV or non HPV associated |
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