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Pathology Unit IV
Gastrointestinal Tract: Appendix
13
Pathology
Graduate
03/06/2013

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Term
pathogenesis of acute
appendicitis
Definition
related to blockage of small central lumen of appendix by fecolith.Mucosa is damaged. Bacteria normally present in large bowel gain access - cause inflammation
Term
clinical symptoms of acute
appendicitis
Definition
Complications - perforation, peritonitis, abscess, adhesions. The pain associate with appendicitis is due to infiltration of the muscle wall of the appendix by inflammatory cells.
Term
important complication of acute
appendicitis
Definition
Mcburney’s sign- deep tenderness notated at a location two thirds of the distance from the umbilicus to right anterior superios iliac spine
Term
mucocele of the appendix definition
Definition
mucus secretion of epithelial cells continues, resulting in a greatly dilated appendix filled with mucus material. This condition is known as pseudomyxoma peritonei - "jelly belly
Term
morphology of mucocele of the appendix
Definition
blocked proximal end (fecolith)
Term
clinical significance of mucocele of the appendix
Definition
Danger is if mucocele ruptures, mucus-producing epithelium can be spread throughout peritoneal cavity and continue to produce mucus
Term
pseudomyxoma peritonei definition
Definition
jelly belly caused by mucus secretion of epithelial cells continues, resulting in a greatly dilated appendix filled with mucus material
Term
morphology of pseudomyxoma peritonei
Definition
Similar condition can occur with a mucinous tumor of the ovary.
Term
clinical significance of pseudomyxoma peritonei
Definition
dangerous if ruptured, can spread
Term
carcinoid tumor of the appendix definition
Definition
most common tumor of the appendix
Term
gross appearance of carcinoid tumor of the appendix
Definition
solid bulbous swelling two to three centimeters in diameter.
Term
clinical significance of carcinoid tumor of the appendix
Definition
Extremely rare for carcinoid tumors of appendix to behave in a malignant fashion. In this location they are generally considered benign and are often only incidental findings, producing no clinical disease.
Term
A 70-year-old previously healthy man noted blood streaked stool and saw his physician. On physical examination the stool was positive for blood, though a lesion could not be palpated by digital rectal examination (DRE). There were no palpable abdominal masses or organomegaly. There was no tenderness and bowel sounds were active. An appendectomy scar was present in the right lower quadrant. A colonoscopy was performed, and there was an area of obstruction from an encircling mass with superficial ulceration that was located at 20 cm above the peri-anal area. Which of the following risk factors was most likely to have been present for development of this lesion?
Definition
prior abdominal surgery .
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