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Pathology Unit IV
Gastrointestinal Tract: Salivary Glands
16
Pathology
Graduate
03/06/2013

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Term
Sialadenitis (definition)
Definition
inflammation
Term
Cause of Sialadenitis
Definition
viral (mumps), bacterial, or autoimmune origin (Sjögren syndrome).
Term
pathogenesis of Sialadenitis
Definition
obstruction of excretory duct by stone which may result in secondary bacterial infection
Term
Clinical significance of Sialadenitis
Definition
bacterial infections are common
Term
incidence of pleomorphic adenoma
Definition
: 75 % of tumors of major salivary glands
Term
clinical features of pleomorphic adenoma
Definition
Contain epithelial elements in a background of gelatinous, mucoid, myxoid, and/or chondroid tissue.
Term
course of disease of pleomorphic adenoma
Definition
90% are benign, but most are slow growing and well demarcated and located in superficial parotid, excision is difficult due to involvement of facial nerve, 10% recur after surgery
Term
incidence of adenolymphoma
Definition
5-10% of salivary tumors (parotid gland)
Term
clinical features of adenolymphoma
Definition
: Consists of cyst or cleft-like spaces lined by tall columnar cells with granular, very eosinophilic (pink) cytoplasm, associated with abundant lymphoid tissue
Term
course of disease of adenolymphoma
Definition
Slow growing, benign tumor cured by excision
Term
incidence of mucoepidermoid tumor
Definition
5-10% of salivary tumors, most often in the parotid glands
Term
clinical features of mucoepidermoid tumor
Definition
Composed of mixtures of squamous cells, mucus-secreting cells, and intermediate cells
Term
course of disease of mucoepidermoid tumor
Definition
Tumors range from benign to overtly malignant, biologic behavior may be difficult to predict from histology. Overtly malignant tumors metastasize to regional nodes and distant sites. Five year survival for well-differentiated tumors - 90%; poorly differentiated- 20-30%
Term
incidence of adenoid cystic carcinoma
Definition
uncommon, low-grade tumor of major salivary glands occurs more often in minor salivary glands
Term
clinical features of adenoid cystic carcinoma
Definition
: Composed of small dark cells with scant cytoplasm, forming cystic spaces that contain PAS-positive, mucinous or eosinophilic hyalinized material.
Term
course of disease of adenoid cystic carcinoma
Definition
as malignant tumors, tend to involve nerve, spread through the bloodstream and metastasize to distant sites. Five year survival rate is 60 to 70%; ten year survival drops to 30%; 15 year survival rate - 15%.
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