Term
| How to differentiate if megaloblastic anemia is caused by B12 or folate ? |
|
Definition
Measure methylmalonic acid or
Check RBC folate or
Serum B12 |
|
|
Term
| One health complication that is common to any type of anemia ? |
|
Definition
| High output cardiac failure |
|
|
Term
| In Vitamin B12 deficiency, does methylmalonyl acid and homocysteine increase or decrease ? |
|
Definition
|
|
Term
|
Definition
In a bone marrow aspirate, you don't get any material.
Ex) In aplastic anemia, you do dry tap and only get fat cells |
|
|
Term
| Most common cause of aplastic anemia ? |
|
Definition
|
|
Term
| Translocation and oncogene for Burkitt's Lymphoma ? |
|
Definition
| (8;14) translocation and c-myc oncogene |
|
|
Term
| "Starry sky" pattern of cells seen in what lymphoma ? |
|
Definition
|
|
Term
| Markers for Burkitt's Lymphoma ? |
|
Definition
| CD10, CD19, CD20, Surface IgM |
|
|
Term
|
Definition
|
|
Term
| Markers for Hairy Cell Leukemia ? |
|
Definition
|
|
Term
| Most common complication of multiple myeloma is ? |
|
Definition
|
|
Term
| Hypercalcemia seen in multiple myeloma ? |
|
Definition
|
|
Term
| You see tear-drop cells (dacrocytes) where ? |
|
Definition
|
|
Term
| Normal myeloid : erythroid ratio is ? |
|
Definition
3 : 1
Is a bone marrow index that is used in diagnosing disease
Reversed ratio is in hemolytic anemia |
|
|
Term
| Characteristics of Hereditary Spherocytosis ? |
|
Definition
Aut. Dominant
Increased MCHC
Ankyrin is most common protein
Can see pigment gall stones
Osmotic Fragility test
Negative Coombs test
Trt is splenectomy (eliminates anemia but still have spherocytes)
Howell Jolly bodies after splenectomy |
|
|
Term
| Most common risk factor for G6PD deficiency ? |
|
Definition
|
|
Term
| G6PD is what type of genetic disorder ? |
|
Definition
| X-linked recessive disorder |
|
|
Term
| Heinz bodies are seen in G6PD and Alpha Thalassemia ; what stain can be used to see them ? |
|
Definition
Supravital stain or Crystal blue stain
Also see bite cells |
|
|
Term
| Most definitive test and trt for G6PD enzyme deficiency ? |
|
Definition
G6PD enzyme assay at 1 month post-crisis
Trt is ony supportive therapy |
|
|
Term
| What is rare in G6PD deficiency ? |
|
Definition
| Splenomegaly and gall stones |
|
|
Term
| What test can you do to diagnose PHN (Paroxysmal Nocturnal Hemoglobinuria) ? |
|
Definition
|
|
Term
| Schistocytes and helmet cells seen where ? |
|
Definition
| Microangiopathic Haemolytic Anemia |
|
|
Term
| What is sodium metabisulphate ? |
|
Definition
| Is used in reduction test to diagnose sickle cells |
|
|
Term
| Howell Jolly inclusions and basophilic Stippling are both seen in what disorder ? |
|
Definition
|
|
Term
| What stains positive for PAS and TDT ? |
|
Definition
|
|
Term
| Bone marrow biopsy shows what in apalastic anemia ? |
|
Definition
|
|
Term
| Pre-T cells in ALL have what mutation ? |
|
Definition
|
|
Term
| Characteristics of Haemophilia A ? |
|
Definition
X-linked recessive
Factor 8 deficiency (intrinsic pathway)
Prolonged PTT |
|
|
Term
| Prolonged PTT and prolonged bleeding time is seen in ? |
|
Definition
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