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Pathology Spleen
N/A
32
Pathology
Not Applicable
04/21/2011

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Cards

Term
Splenomegaly Measurement
Definition
>13cm

Most common finding. S&S: LUQ pain or fullness
Term
Splenic Congestion
Definition
Acute: Hypermia (unusual amt of blood)

Chronic: diffuse enlargement of gland

Etiology due to obstructive blood disease
Term
Amyloidosis
Definition
-Storage disease causing starch deposits in organs and tissue
Term
Gaucher's Disease
Definition
Congenital disorder of lipid metabolism
Term
Sickle Cell Anemia
Definition
-Inherited hematologic disease particular to those of African descent
-Acute crisis might yield an enlarged spleen with a decrease in hematocrit. With increasing crisis, spleen would become smaller with areas of infarction and fibrosis
Term
Thalassemia
Definition
-Inherited hematologic disease particular to individuals from the Mediterranean or SE Asia
-Anemia due to deficient synthesis of of hemoglobin
-Gross Splenomegaly
Term
Polycythemia vera
Definition
chronic disease of unknown etiology seen as an increase in RBC mass and hemoglobin concentration.
S & S of fatigue, vertigo, tinnitus, irritability, splenomegaly, flushing of the face, redness and pain in the extremities and bruising
US findings of an enlarged, turgid, spleen. Infarcts and thrombosis are common in polycythemia vera
Term
Letterer-Siwe disease and Hand-Schuller-Christian disease
Definition
seen in pediatric patients as hepatosplenomegaly
Term
Splenic abscess
Definition
-Focal Disease of Spleen
-Usually due to suppressed immune system, subacute bacterial endocarditis
-S & S of LUQ tenderness, abd pain
Term
Splenic Infection
Definition
Most often presents as splenomegaly
More often seen in immunocompromised patients
Term
AIDS
Definition
-Focal disease of spleen
-Splenomegaly with possible focal lesions
Term
Splenic infarction & trauma
Definition
-due to occlusion of the splenic artery
-focal, wedge-shaped defect that varies in appearance depending on the time of onset
Term
Splenic Trauma
Definition
-Usually due to blunt abdominal trauma
-results in hematoma
--May be subcapsular or may be ruptured
--Must assess for free fluid in the intraperitoneum
Term
Splenic cysts
Definition
-Appears as true cyst
-May be parasitic or nonparasitic
Term
Echinococus
Definition
Parasite that forms in cysts
Term
Benign Primary Neoplasms
Definition
-Hamartoma
-Cavernous hemangioma
Term
Lymphoma
Definition
-Malignant Primary Neoplasms
-Usually seen as hypoechoic lesions
Patterns of Diffuse involvement,
Focal small nodular lesions,
Focal large lesions,
Bulky disease,

Usually seen as hypoechoic lesions
Patterns of
Diffuse involvement,
Focal small nodular lesions,
Focal large lesions,
Bulky disease

Mets may originate from primary breast, lung, ovary , stomach, or prostate—most commonly from melanoma
Term
Origins for Metastatic Disease
Definition
Mets may originate from primary breast, lung, ovary , stomach, or prostate—most commonly from melanoma
Term
significance and findings in trauma to the spleen
Definition
Enlarged; hematoma; Subcapsular vs. ruptured
Term
Accessory Spleen
Definition
Results from failure of fusion of separate splenic masses forming on dorsal mesogastrium

Most commonly found at splenic hilum or along splenic vessels
Term
Reticuloendothelial
Definition
Certain phagocytic cells make up the RES; plays role in synthesis of blood proteins and hematopoiesis
Term
Wandering Spleen
Definition
Spleen that has migrated from its normal LUQ location
Term
Culling
Definition
Process by which spleen removes red blood cells as they pass through
Term
Hemosiderin
Definition
Pigment released from hemoglobin process
Term
Leukopenia
Definition
Abnormal decrease of WBC; may be drug induced
Term
Malpighian Corpuscles
Definition
Found in white pulp; lymph node in spleen
Term
Phagocytosis
Definition
Process by which the red pulp destroy the degenerating red blood cells
Term
Pitting
Definition
Process by which spleen removes red blood cells as they pass through
Term
Red Pulp
Definition
Consists of reticular cells and fibers, surrounds the splenic sinuses
Term
White pulp
Definition
Consists of lymphatic tissue and lymphatic follicles
Term
Autoimmune Hemolytic Anemia
Definition
Anemia caused by antibodies produced by one's immune system
Term
Hemolytic Anemia
Definition
Anemia resulting from hemolysis of RBCs
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