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Pathology GI and Endocrine
Pathology
53
Pathology
Graduate
12/04/2018

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Term
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Definition
Morphological Diagnosis: Multifocal Acute Moderate Ruminitis
Distribution: Multifocal
Severity: Severe?
Process: Inflammatory, infectious- Mycotic/fungal species such as Mucor, Aspergillus, Rhizopsus, and absidia species causes circular and well delineated infarction and thrombosis
Term
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Definition
Diagnosis: Bloat Line
Process: Indicates that the cow could not eructate, leading to the buildup of gas within the rumen and the susequent compression of the esophagus, leading to ischemia
Term
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Definition
Cholelith
Term
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Definition
Nutmeg appearance due to Chronic Passive Congestion
Chronis
Term
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Definition
Chronic Passive Congestion with Nutmeg Appearance
Chronic
Term
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Definition
Cirrhosis- presence of regenerative nodules separated by fibrous septa due to chronic hepatitis
Severe
Term
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Definition
Process: deposition of fibrin, pyogranulomatous inflammation, or edema
- Feline infectious peritonitis- Coronavirus
Term
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Definition
Process: Fibrosis takes place in responses to chronic inflammation
-Chronic
Diagnosis: Chronic Moderate Multifocal Hepatic Fibrosis
Term
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Definition
Lesions in the lover often develop secondary ruminal acidosis or rumenitis.
Most likely diagnosis: Hepatic abscesses caused by Fusobacterium necrophorum infection or by Corynebacterium spp
Term
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Definition
Condition: Hepatic Lipidosis
DAMNITV: Metabolic, Degenerative, Nutritional
Chronic
Term
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Definition
Herniation
- Rent in the mesentery with the intestines displaced through the rent
Term
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Definition
Icterus/Jaundice
Term
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Definition
Intussusception
- telescoping of intestine inside intestine
Term
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Definition
Johne's disease
- Granuloma/granulomatous hyperplasia
- Granulomas of the intestines and thickening of the mucosal folds caused by Mycobacterium avium
Term
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Definition
DAMNITV: Neoplastic
Diagnosis: Lymphoma
Distribution: Multifocal
Severe and Chronic
Term
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Definition
Metabolic Bone Disease
- Pathogenesis: calcium/phosphorous imbalance in the body (commonly due to a vitamin D deficiency) which causes a weakening if the skeletal structure via increased activity of the parathyroid gland to mobilize calcium from bone tissue
Term
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Definition
White spots are from necrosis
Organs present: Liver, lungs, heart, diaphragm, jejunum/intestines
Term
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Definition
Lesion- Nodular hyperplasia
Term
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Definition
Distribution: Focal
Differential: Pancreatic Adenocarcinoma
Term
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Definition
Parakeratosis
- Diet that maintains a high grain concentration leads to the rapid production of volatile fatty acids, which lowers the pH of the rumen. Lower pH promotes the proliferation of lactic acid-producing bacteria which further lower the pH. In a chronic fashion, low pH promotes the compensatory keratinization of ruminal papillae to prevent damage and also decreases absorption across the ruminal epithelium.
Chronic
Term
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Definition
DAMNITV: Neoplastic
Process (note color of jejunum): Pedunculated Lipoma causing strangulation and occlusion of blood supply in a horse
Term
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Definition
Adrenal Gland Medulla affected
Pathology: Pheochromocytoma
Term
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Definition
Pituitary gland adenoma
Secondary diseases: hyperadrenocorticism and hyperthyroidism
What happens to the surrounding tissue? Compression atrophy
Term
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Definition
Morphological Diagnosis: Diffuse Severe Subacute to Chronic Proliferative Enteritis with Hemoorhage
Organism involved= Lawsonia intracellularis
Lesion: Markedly thickened mucosa throughout the section with a blood clot (red bloody cast)
Term
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Definition
Organ: Pancreas
Acute- Saponification/Fat Necrosis
Term
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Definition
Process: Saponification- trauma to the pancreas or acute pancreatitis leads to acinar cell damage which leads to the release of lipases, resulting in degradation of triglycerides into fatty acids. Free fatty acids accumulate with salt and calcium to form deposits throughout the tissue
Term
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Definition
Process: Necrosis
Severe
Term
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Definition
Etiological Diagnosis: Bacterial Dermatitis or Erysipelas Dermatitis
Process: Hemorrhage or Ischemia and Necrosis (Skin Infarcts)
Term
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Definition
Etiological Diagnosis: Bacterial Dermatitis or Erysipelas Dermatitis
Process: Hemorrhage or Ischemia and Necrosis (Skin Infarcts)
Term
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Definition
Intestine from pig
DAMNITV: Infectious, Inflammatory
Disease: Brachyspira hyodysenteriae
Term
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Definition
Morphological Diagnosis: Diffuse Severe Subacute to Chronic Proliferative Enteritis with hemorrhage
Organism: Lawsonia intracellularis
Describe Lesion: Markedly thickened mucosa throughout the section with a blood clot (red bloody cast)
-Proliferative Enteritis
Term
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Definition
Thyroid Carcinoma which causes hypothyroidism in dogs
Term
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Definition
Torsion or Volvulus of the large colon
Sequestra: Ischemia occurs due to the compression of both arteries and veins, obstruction, bloat, pain
Species: horse
Term
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Definition
Unilateral adrenal cortical adenoma
How does this impact the other adrenal gland? Cortical atrophy of contralateral gland
Term
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Definition
Unilateral thyroid adenoma
DAMNITV: Neoplastic, degenerative, metabolic
Term
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Definition
Diffuse Hyperplastic Goiter
- Both lobes of thyroid are uniformly enlarged (mostly young animals)
Term
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Definition
Colloid Goiter
- Hyperplastic follicular cells continue to produce colloid but endocytosis of colloid is decreased from low pituitary TSH
-Bilateral diffuse enlargement but paler in color and translucent due to macrofollicles filled with colloid
Term
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Definition
Inherited Dyshormonogenetic Goiter
- Autosomal recessive trait
-Common in goats and young animals
-Inability to synthesize and secrete adequate amounts of thyroid hormones
- Symmetric enlargement of thyroids at birth due to intense hyperplasia of follicular cells
Term
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Definition
Inherited Dyshormonogenetic Goiter
- Autosomal recessive trait
-Common in goats and young animals
-Inability to synthesize and secrete adequate amounts of thyroid hormones
- Symmetric enlargement of thyroids at birth due to intense hyperplasia of follicular cells
Term
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Definition
Nodular Hyperplasia
Older animals
- Multiple white-tan nodules of varying size
- Poorly to non encapsulated; do not cause compression of adjacent parenchyma
Term
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Definition
Term
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Definition
White to tan
- Tend to be solitary, small
- Well encapsulated
- Can cause compression due to expansile growth but thyroid gland only moderately enlarged or distorted
Term
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Definition
White to tan
- Tend to be solitary, small
- Well encapsulated
- Can cause compression due to expansile growth but thyroid gland only moderately enlarged or distorted
Term
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Definition
Follicular Cell Carcinoma
-Can be uni/bilateral
-Most palpable near larynx
- Can cause respiratory distress if impinged on larynx and trachea
-Not freely movable
Term
Dogs get thyroid carcinoma more than adenomas
Cats get adenomas more than carcinoma
Definition
Term
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Definition
Diffuse cortical hyperplasia
-hypertrophy and hyperplasia of zona fasiculata and zona reticularis in reponse to autonomous hypersecretion of ACTH by a corticotroph adenoma of pituitary gland
Term
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Definition
- Occur most frequently in older dogs
- Usually single, unilateral, well demarcated
- Larger ones are yellow to red and distort contour of the gland
Term
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Definition
Well defined spherical nodules in the cortex or attached to the capsule
-Hyperplastic nodules are usually multiple, bilateral, yellow
Term
Adrenocortical adenoma
Definition
Adenoma of adrenal cortex
- Usually unilateral; arise from cortex
- Usually circumscribed but incompletely encapsulated; grow by expansion
Term
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Definition
Cortical adenomas and carcinomas
- Cause severe atrophy of contralateral adrenal
Term
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Definition
Hyperpigmentation- excess of pituitary melanocyte-stimulating hormone that develops due to decrease of inhibitory adrenocortical hormone
Addison's disease
Term
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Definition
Adrenal Pheochromocytoma
- Dark reddish brown; variegated due to areas of hemorrhage and necrosis
- Single to multiple
-Incomplete encapsulated
- Lipofuscin may be seen at periphery tumor
- Some secrete epi/norepi
Term
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Definition
Adrenal Pheochromocytoma invasion of the vena cava
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