Term
|
Definition
| Activates platelet aggregation; causes release of ADP for platelet aggregation |
|
|
Term
|
Definition
| amplifies platelet aggregation |
|
|
Term
| PAR- protease activated receptor |
|
Definition
| Binds to thrombin to cause aggregation |
|
|
Term
|
Definition
| Large protein that bridges between platelets to promote aggregation |
|
|
Term
|
Definition
| binds leukocytes to platelets and endothelium |
|
|
Term
|
Definition
| Stimulates neutrophil and macrophage adhesion and promotes inflammation |
|
|
Term
|
Definition
| Most important coagulation factor |
|
|
Term
|
Definition
| Stabilizes fibrin polymers in secondary plug |
|
|
Term
| Factor XII- Hageman factor |
|
Definition
| Starts intrinsic clotting cascade when exposed to thrombogenic surface |
|
|
Term
|
Definition
| Inhibits activity of thrombin; binds to heparin-like molecules of endothelium |
|
|
Term
|
Definition
| Inactivates Tissue Factor- Factor VIIa complex |
|
|
Term
| D-dimers/Fibrin Split Products |
|
Definition
| Diagnostic for DVT, DIC, Pulmonary Edema |
|
|
Term
|
Definition
| Catabolized to make plasmin |
|
|
Term
| Alpha 2 Plasmin Inhibitor |
|
Definition
| Restricts and deactivates plasmin |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Acts as a target for antibodies when bound to heparin in cases of Heparin Induced Thrombocytopenia (HIT) |
|
|
Term
|
Definition
| Required for trophoblast invasion of the uterus |
|
|
Term
|
Definition
| The cause of widespread thrombi in DIC |
|
|
Term
|
Definition
| Activated by endotoxin to promote coagulation |
|
|
Term
|
Definition
| Inhibits platelet aggregation; potent vasodilator |
|
|
Term
|
Definition
| Cofactor in the coagulation pathways |
|
|
Term
|
Definition
| A gene mutation for this factor causes HYPERcoagulability |
|
|
Term
|
Definition
| Prevents thrombosis- is activated by Heparin |
|
|
Term
|
Definition
| Binds to thrombin and inhibits coagulation by activating protein C |
|
|
Term
|
Definition
| Promotes platelet aggregation |
|
|
Term
|
Definition
| Degrades ADP and inhibits platelet aggregation |
|
|
Term
|
Definition
| Convergence of the extrinsic and intrinsic coagulation pathways |
|
|
Term
|
Definition
| Deficiency causes Hemophilia B |
|
|
Term
|
Definition
| Deficiency causes Hemophilia A |
|
|
Term
|
Definition
| Reduced/deficient in Von Willebrands Disease (Not vWF) |
|
|
Term
|
Definition
| Inhibits Va and VIIIa- if deficient, causes hypercoagulability |
|
|
Term
|
Definition
| Required for heparin binding |
|
|
Term
|
Definition
| Cause platelet aggregation; can be inhibited by aspirin |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Administered for prophylaxis for DVT |
|
|
Term
|
Definition
| released in brain injury; starts extrinsic pathway (also called Tissue factor, factor III) |
|
|
Term
|
Definition
| released in brain injury; starts extrinsic pathway (also called thromboplastin, factor III) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Deficiency causes increased bleeding time; binds to factor VIII causing platelet adhesion |
|
|
Term
|
Definition
| Activates clotting in sepsis |
|
|
Term
| D-dimers/Fibrin split products |
|
Definition
| Signify elevated fibrinolysis |
|
|
Term
|
Definition
| Potent endothelial-derived vasoconstrictor |
|
|
Term
|
Definition
| exposed at site of injury- procoagulant glycoprotein- acts with factor VII |
|
|
Term
|
Definition
| Acts with factor III to initiate extrinsic clotting cascade |
|
|
Term
|
Definition
| Result of clotting cascade- cleaves fibrinogen to fibrin |
|
|
Term
|
Definition
| recruits and activates platelets |
|
|
Term
| Tissue Plasminogen Activator |
|
Definition
| Limits the size of the clot plug- cleaves plasminogen to make plasmin |
|
|
Term
|
Definition
| Produced by endothelium; prevents platelet adhesion; vasodilator |
|
|
Term
|
Definition
| Produced by endothelium; prevents platelet adhesion; causes vasodilation |
|
|
Term
|
Definition
| Heparin-like anticoagulant; converts thrombin from procoagulant to anticoagulant form via Protein C |
|
|
Term
|
Definition
| Heparin-like anticoagulant on cell surface that inhibits Factor VIIa and Xa |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Cleaves fibrin to degrade thrombosis |
|
|
Term
|
Definition
| Limits fibrinolysis- favors thrombosis |
|
|
Term
|
Definition
| Bridge between platelet surface receptors and exposed collagen |
|
|
Term
|
Definition
| Platelet surface receptor |
|
|
Term
|
Definition
| Serum- antiprotease- stops inflammation |
|
|
Term
|
Definition
| Neutrophil- antiprotease- stops inflammation |
|
|
Term
|
Definition
| Major activator of macrophages |
|
|
Term
|
Definition
| Chemokine for eosinophil recruitment |
|
|
Term
|
Definition
| Toxic to parasites AND mammalian epithelium |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Secreted by activated T-Cells; mediates granulomatous inflammation |
|
|
Term
| Tumor Necrosis Factor (TNF) |
|
Definition
| Secreted by activated macrophages; activates lymphocytes and fibroblasts |
|
|
Term
|
Definition
| Complement fragment that is chemotactic for neutrophils |
|
|
Term
|
Definition
| From macrophages- promotes fibrosis |
|
|
Term
|
Definition
| Potent vasodilator that takes over after the short-term effects of histamine |
|
|
Term
| Sialyated Oligosaccharides |
|
Definition
| Bind to selectins in rolling of neutrophils |
|
|
Term
|
Definition
| Binds to integrins in firm adhesion |
|
|
Term
|
Definition
| A genetic lack of this prevents firm adhesion- cause of LAD |
|
|
Term
|
Definition
| Contracts endothelium; separates gap junctions; increases permeability |
|
|
Term
|
Definition
| Increased permeability that is delayed in onset and long in duration |
|
|
Term
|
Definition
| Ligands for leukocyte adhesion molecule CD44 |
|
|
Term
|
Definition
| Move P-selectin from stores to cell surface (along with histamine and thrombin) |
|
|
Term
|
Definition
| Stimulate venular adhesion molecules |
|
|
Term
|
Definition
| Stimulate adherent leukocytes to pass through interendothelial spaces |
|
|
Term
|
Definition
| Major roll in ROLLING of leukocytes |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Critical complement activator |
|
|
Term
|
Definition
| Vasodilator from platelets and enterochromaffin cells |
|
|
Term
|
Definition
| Main link between coagulation system and acute inflammation |
|
|
Term
|
Definition
| Initiates clotting, kinins, fibrinolysis, and complement |
|
|
Term
|
Definition
| Inhibit leukocyte recruitment and block cellular components of inflammation |
|
|
Term
|
Definition
| Causes most of the features of inflammation |
|
|
Term
|
Definition
| Causes bronchoconstriction and vasoconstriction as well as leukocyte adhesion |
|
|
Term
|
Definition
| Calcium independent inducible NOS |
|
|
Term
|
Definition
| Vasodilation, platelet antagonism, reduced leukocyte recruitment, microbicidal activity |
|
|
Term
|
Definition
| Mutations in the gene for this cause increased thrombosis and increased PT |
|
|
Term
|
Definition
| Antibodies binding to this give false positive for syphillis |
|
|
Term
|
Definition
| How platelets adhere to vWF |
|
|
Term
|
Definition
| Without this cofactor, bleeding is the result due to a breakdown of multiple pathways |
|
|
Term
|
Definition
| How platelets bind to each other using fibrinogen and this |
|
|
Term
|
Definition
| Antibodies against this are antiplatelet; this is seen in ITP |
|
|
Term
|
Definition
| ELIZA test for this is elevated in pulmonary embolism |
|
|
Term
|
Definition
| High levels of this cause the release of TNF, IL-1, IL-6, and IL-8 |
|
|
Term
|
Definition
| Powerful chemotactic factor and activator of neutrophils; increases vascular permeability |
|
|
Term
|
Definition
| Opsonin that promotes phagocytosis |
|
|
Term
|
Definition
| Release of this is stimulated by C3a and C5a |
|
|
Term
|
Definition
| Chemotactic for neutrophils, eosinophils, lymphocytes, monocytes, and basophils |
|
|
Term
|
Definition
| Causes pain and increased vascular permeability |
|
|
Term
|
Definition
| Vasodilation at the site of inflammation |
|
|
Term
| IL-1 and Tumor Necrosis Factor |
|
Definition
| Leukocyte release from the bone marrow |
|
|
Term
|
Definition
| Major fever producing cytokines |
|
|
Term
|
Definition
| Leukocyte transmigration- firm adhesion |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Transforms macrophages into epitheliod cells in granulomatous inflammation |
|
|
Term
|
Definition
|
|
Term
|
Definition
| FEVER- stimulates hypothalamus |
|
|
Term
|
Definition
| C-reactive protein; fibrinogen; serum amyloid A protein- opsonization and clearing of necrotic cells |
|
|
Term
|
Definition
| Causes RBC to stack up- ROULEAUX |
|
|
Term
|
Definition
| Endothelial surface receptor that converts thrombin from pro-coag to anti-coag |
|
|
