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Pathology exam 3 General Concepts
General Concepts for exam 3
111
Pathology
Graduate
08/29/2016

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Term
5 etiologies of peripheral nerve injuries.
Definition
Diabetes Mellitus
Ethanol Abuse
Trauma
Herniated Nucleus Pulposus
Guillan-Barre
Term
Diabetes Mellitus and PNI
Definition
Axonopathy caused by high blood sugar that begins distally in the legs and feet.
Term
Ethanol Abuse and PNI
Definition
Those who drink alcohol heavily may have resulting in axonopathy and myelinopathy
from the toxicity of alcohol.
Term
Trauma and PNI
Definition
Laceration, GSW’s, fractures, traction injuries, and thermal injuries can either sever the nerves or cause tissue death.
Term
Herniated Nucleus Pulposus and PNI
Definition
When the nucleus pulposus herniates and compresses the spinal nerve resulting in radiculopathy.
Term
Guillan-Barre and PNI
Definition
 rapid-onset muscle weakness caused by autoimmune response with antibodies in the myelin after an immunization, surgery, or viral respiratory infection. Immune system attacks myelin
Term
2 general categories of Peripheral Nerve injuries
Definition
Primary Myelinopathy- where the myelin goes bad on the neuron

Primary Axonopathy – where both the axon and the myelin goes bad (the myelin can’t survive without a healthy axon)
Term
classifications of nerve injuries by Seddon.
Definition
-Neurapraxia
-Axonotmesis
-Neurotmesis
Term
Neurapraxia
Definition
Local conduction block with normal nerve conduction proximal then distal to the lesion.

Usually a compression, it usually gets better within seconds, but can last longer.
Term
Axonotmesis
Definition
The axon and neurolemma are disrupted, but the endoneurium is intact. Recovery is usually good, but slow.
Term
Neurotmesis
Definition
The nerve is severed or torn entirely, it must be surgically repaired, and the recovery is poor.
Term
List 5 clinical manifestations of peripheral nerve injuries
Definition
o Sensory loss in the nerve field
o Projected pain
o Diminished 2-point discrimination
o Motor weakness and atrophy
o Altered vascular response (usually diminished).
Term
What are the functions of the inner ear?
Definition
o Stabilize visual images
o Postural stability
o Spatial orientation
Term
List and describe the otolith organs.
Definition
o Utricle – horizontal and tilt perception
o Saccule – vertical perception
Term
List and describe 5 types of “dizziness.”
Definition
o Disequilibrium – feeling of being off balance or unsteady at the feet

o Lightheaded – “woozy” check BP and blood glucose levels

o Vertigo – perception of internal or external motion (you are moving or the ground is moving)

o Behavioral – anything from fear/avoidance to secondary pain.

o Motion Intolerance – negative response to body motion or perceived motion (car wash or car next to you moving causing a feeling of reverse movement),
Term
5 pathologies of the vestibular system.
Definition
-Motion Sickness
-Mal De Debarquement
-Presbystasis
-Meniere’s Disease
-BPPV – Benign paroxysmal positional vertigo.
-Perilymphatic Fistula
Term
Motion Sickness
Definition
vestibular system has a hard time sifting through the stimuli information and
causes the body to feel sick.
Term
Mal De Debarquement
Definition
the body syncs to the rock of the boat, but when you arrive on land your
body gives sensation of movement that was felt on the boat.
Term
Presbystasis
Definition
natural dizziness due to aging. The stereocilia and kenocilia start to lose function.
Term
Meniere’s Disease
Definition
over production of the fluid in the inner ear region. The area cannot expand to accommodate the extra fluid and causes HeadAche, pain, vertigo, ringing in the ears, and increased motion perception.
Term
BPPV
Definition
Benign paroxysmal positional vertigo. An intermittent sensation of vertigo that occurs depending on certain body positions.
Term
Perilymphatic Fistula
Definition
a tearing in the membrane between the middle and inner ear causing problems with regulating internal pressure.
Term
alzheimer's disease
what's going on?
Definition
gradual and progressive onset.
A change in the neurons where plaques from on axons and dendrites of neurons, causing the dendrites to retract and eventually disconnect from one another
Term
Alzheimer's disease
symptoms
Definition
AMNESIA - memory deficit
APHASIA - inability to communicate
APRAXIA - loss of ability to perform learned tasks
AGNOSIA - inability to self-observe
Term
Alzheimer's disease
-Mild Stage
Definition
-slight personality changes
-they will try to hide it
-will have difficult with tasks
Term
Alzheimer's disease
-moderate stage
Definition
-no obvious cognitive impairment
-need supervision
-have more frequent behavior problems
Term
Alzheimer's disease
-severe stage
Definition
-patients do not recognize those close to them (e.g., children, family)
-often institutionalized
-personality and behavioral changes
-any communication is difficult
Term
alzheimer's disease survival rate
Definition
8 years after diagnosis
Term
alzheimer's disease treatment
Definition
Acetylcholinerase inhibitors
Term
alzheimer's disease risk factors
Definition
 Age

Head injury earlier in life
Females
Genetics
Low socioeconomical status
Term
Multiple sclerosis
what's going on, generally?
Definition
Immune response to plaques forming in the CNS.
T-cells destroy plaques but also myelin surrounding nerve axons, causing lesions and scar tissue that inhibit the ability to send and receive signals
Term
Multiple sclerosis
-s&s
Definition
-sensory changes first
-blurred and double vision
-weakness
-balance problems
Term
4 types of multiple sclerosis
Definition
-Relapsing-Remitting Multiple Sclerosis
-Secondary-Progressive Multiple Sclerosis
-Primary-Progressive Multiple Sclerosis
-Progressive-Relapsing Multiple Sclerosis
Term
Relapsing-Remitting Multiple Sclerosis
Definition
Person experiences attack and then it backs off periodically through life
Term
Secondary-Progressive Multiple Sclerosis
Definition
Goes with the relapsing remitting ms where the attacks decrease however, the progression increases
Term
Primary-Progressive Multiple Sclerosis
Definition
Never really had an attack, person just starts off progressive and has a steady decline
Term
Progressive-Relapsing Multiple Sclerosis
Definition
Eventually a person with primary-progressive will have an attack, then they will be categorized of having progressive-relapsing MS
-- Average attack is 1x/year
Term
Multiple Sclerotic Syndromes
Definition
- Corticospinal- stiffness, slowness, weakness, spasticity, paresthesia
- Brainstem- gaze palsy, nystagmus, dysarthria, ocular mobility impairments
- Cerebellar- weakness, postural and movement disorders
- Cerebral- memory loss, optic nerve changes, depression, behavioral changes
Term
TREATMENT OF MULTIPLE SCLEROSIS
Definition
- Immunosuppressant drugs
- Corticosteroids
- ACTH
Term
Parkinson’s disease
-what's going on, generally
Definition
Progressive idopathic disease affecting the grey matter of the basal ganglia. The reduction in dopamine production affects movement, coordination, and general control
Term
parkinson's disease
-s&s
Definition
tremors
bradykinesia
akinesia
freezing
rigidity
Term
parkinson's disease
clinical manifestations
Definition
-postural instability - (bent posture, altered center of gravity)
-tremors
-gait slowed, shuffling, stiff
Term
parkinson's disease treatment
Definition
-Dopamine supplement therapy
---L dopa, carbidopa
-Weight shifting
-get the patient to do things out of the ordinary: (wake up and stimulate pathways)
---stamp feet, rhythms, clapping, backward walking---
Term
ALS What is it?
Definition
Amyotrophic lateral sclerosis -disease of motor neurons causing wasting of neurons that control voluntary muscles. Muscles atrophy
Term
ALS
s&s
Definition
amyotrophic lateral sclerosis
-weakness (asymmetric)
-deformities
-oral flaccidity(Bulbar signs)
-dyspnea
-atrophy
Term
Exercise with Stage 1-3 ALS
Definition
INDEPENDENT
-ROM, stretching
-AVOID contractures
-non-fatiguing
-use adaptive equipment
Term
Exercise with Stage 4-5 ALS
Definition
SEMI DEPENDENT
-chair transfers
-positioning
-adaptations
Term
Exercise with Stage 6 ALS
Definition
BED RIDDEN
-completely dependent ADL's
Term
Stroke is due to
Definition
vascular event that destroys surrounding brain tissue
Term
Infectious diseases of the CNS
Definition
-Meningitis
-Encephalitis
-Brain Abscess
Term
Infectious diseases of the CNS
-RISK FACTORS
Definition
-insect bites
-contaminated food
-exposure to bodily fluids
-penetrating trauma
-weakened immune system
Term
how to diagnose infections of the CNS
Definition
-lumbar.spinal puncture to extract CSF
-MRI/CT
Term
Infectious diseases of the CNS
-treatment
Definition
-antibiotics
-corticosteroids
-craniotomy
Term
meningitis
-signs and symptoms
Definition
-headache
-fever
-stiff neck
-vomiting
-seizures
-weakness
Term
etiology for encephalitis
Definition
-insect bites (west nile virus)
-mumps
-rubella
-herpes
Term
west nile virus
-s&s
Definition
headache
nausea
fatigue
pain
chills
Term
etiology of brain abscess
Definition
-infections that produce pus and dead tissue in the brain
-infection can spread from the ear, teeth, sinuses...
Term
neoplasms
-primary vs secondary tumors
Definition
primary: develops in the brain/spinal cord
secondary: metastic, spread to the CNS from another site such as the lungs
Term
brain tumors
s&s
Definition
-headache
-pain
-fatigue
-nausea
-vomiting
-lethargy
-blurred vision
Term
PT implications for brain tumor
Definition
-a very thorough evaluation should be performed focusing on balance, headaches, and weakness
-keep in mind that they may be on chemo or radiation
-review the lab values
Term
signs of hematologic disorders
Definition
-edema
-congestion
-infarction (not enough oxygen)
-thrombosis
-embolism
-lymphedema
-bleeding and bruising
-shock
-lymphadenopathy
Term
early manifestations of shock
Definition
-tachycardia
-pallor
-sweating
-syncope
-anxiety
Term
amenia is...
(everything)
Definition
a decreased number of RBC
-caused by increased destruction of erythrocytes or lack of production
-Less oxygen = less energy
-TREATMENT: bone marrow replacement, nutrition
Term
Leukocytosis
Definition
-increased number of WBC in the system
-usually a sign of infection if above 10,000
Term
leukopenia
Definition
decreased number of WBC in system
Below 5000 WBC/mm3
causes: immunosuppression, HIV, radiation/chemotherapy
Term
Leukemia
what is it?
Definition
Cancer of the WBC - uncontrollable production of WBC
-this can lead to anemia, since WMC compete for resources
Term
Four types of Leukemia
Definition
- Acute Lymphoblastic Leukemia (ALL)
- Chronic Lymphoblastic Leukemia (CLL)
- Acute Myeloid Leukemia (AML)
- Chronic Myeloid Leukemia(CML)
Term
Acute leukemia (ALL and AML )
-describe
Definition
High proportion of (blast) immature, nonfunctional cells in bone marrow and peripheral circulation
-abrupt onset and complications occur
Term
Chronic leukemia (CLL and CML)
-describe
Definition
Higher proportion of mature cells
Insidious onset
Mild signs and better prognosis
More common in older people
Term
Acute leukemia
s&s
Definition
o Severe and steady bone pain
o Weight loss
o Fatigue
o Fever
o Headache
o Blurry vision
o Vomiting
Term
Chronic leukemia
s&s
Definition
o Fatigue
o Weight loss
o Anorexia
o 40% is asymptomatic
o Can progress from chronic to acute
Term
2 types of lymphomas
Definition
Hodgkin’s Lymphoma
non-Hodgkin’s Lymphoma
Term
Hodgkin’s Lymphoma
Definition
o First sign is an enlarged painless lymph node
o Followed by splenomegaly
o Treatment:
----Radiation and chemotherapy
Term
Non-Hodgkin’s Lymphoma
Definition
o Solid tumors are formed from cells and travel
o Treatment:
---- Radiation to break up local tumors
---- Chemotherapy for more wide spread disease
Term
4 stages of lymphoma
Definition
o 1-early stage cancer found in lymph node
o 2-cancer found two or more lymph nodes
o 3-Spread to lymph nodes above and below diaphragm
o 4-cancer is found in several organs
Term
Multiple Myeloma
-what is it?
Definition
 Increased production of plasma cells in the bone marrow which travel to the lymphoid system
 Multiple tumors are found in the bone
Term
Multiple Myeloma
-s&s
Definition
o Bone pain
o Bone loss
o Fracture of bone due to bone loss
o Looking for dark spots on the Radiographs
Term
Thrombocytopenia
Definition
a condition where decreased number of platelets in system
Term
Von Willebrand’s Disease
Definition
 Inherited Bleeding disorder
 people bruise easily because of lack of clotting factors
Term
Hemophilia
-what is it?
Definition
-inherited clotting disored
-manifested in men but carried by women
Term
Hemophilia
-s&s
Definition
prolonged bleeding after trauma
bleeding in gums, into joint (hemarthrosis)
hematuria
Term
hemophilia treatment
Definition
Desmopressin (DDAVP)
Replacement therapy for factor VIII
Blood transfusions
Term
hemophilia and physical therapy concerns
Definition
As a PT, we need to be on the defense. We need to educate these patients that prevention is the key.

Bleeding in the joints are not good. Some people get clotting disorders by taking too many NSAIDS.
Term
 What is Lymphedema?
Definition
o Accumulation of lymph in the extracellular spaces
o Due to a blockage in the lymphatic vessels
o Primary- born with it
o Secondary- get it due to damage of lymph vessels
o Can cause functional and structural impairments
Term
4 Stages of Lymphedema
Definition
o 0-lymph circulation is reduced
o 1-Pitting edema
o 2- non-pitting edema, scar tissue
o 3-non- pitting edema with significant connective and scar tissue build up (elephantitits)
Term
Lymphedema
s&s
Definition
o Skin tightness
o Feeling of having “full skin”
o Tight fitting clothes and jewelry
o Skin changes
Term
physical therapy considerations for lymphedema
Definition
 Be Infection control
 Compression stockings
 Exercise (muscle pump)
 Educate the patient
Term
Lymphadenitis
Definition
 Inflammation of the lymph nodes
Term
Lymphangitis
Definition
Inflammation of the lymph vessels
Term
Lipedema
Definition
Often confused with lymphedema but instead is an accumulation of fat in the areas usually arms and legs
Term
Hemorrhagic stroke
-what is it?
-treatment
Definition
Hemorrhage is a ruptured blood vessel (more lethal than ischemic)
-DO NOT USE BLOOD THINNERS
Term
Ischemic stroke
-what is it?
-treatment
Definition
Ischemic is usually due to a thrombus or embolism blocking a vessels passage of blood to the brain, Causing it to be deprived of oxygen
-treat:use blood thinners
Term
Uterine Prolapse
Definition
Uterus protrudes outside of the vagina
Term
Pelvic Floor Dysfunction
Definition
Decreased ability to use the muscles of the pelvic floor to do functional tasks
Term
What are 5 types of prolapses?
Definition
 Cystocele -
 Rectocele -
 Uterine prolapse -
 Enterocele prolapse -
 Vaginal vault prolapse -
Term
Cystocele
Definition
tough fibrous wall between a woman's bladder and her vagina is torn by childbirth, allowing the bladder to herniate into the vagina.
Term
Rectocele
Definition
tear in the rectovaginal septum
Rectal tissue bulges through this tear and into the vagina as a hernia.
Term
Uterine prolapse
Definition
uterus protruding from the opening of the vagina
Term
vaginal vault prolapse
Definition
the upper portion of the vagina loses its normal shape and sags or drops down into the vaginal canal or outside of the vagina
Term
enterocele
Definition
the small intestine (small bowel) descends into the lower pelvic cavity and pushes at the top part of the vagina, creating a bulge
Term
Symptoms of pelvic organ prolapse
Definition
 Vaginal Bulging
 Pelvic Pressure
 Feel the need to manually put pressure on vagina
 Low back pain
Term
causes of pelvic organ prolapse
Definition
 Pregnancy
 Obesity
 Respiratory problems
 Constipation
 Pelvic cancer
Term
Pelvic Inflammatory Disease
-what is it?
-what does it cause?
Definition
-Inflammation of the pelvis and surrounding tissue due to infection of female upper genital tract

- Common cause of ectopic pregnancy (pregnancy in fallopian tube), infertility, and chronic pain
Term
Pelvic Inflammatory Disease
s&s
Definition
o Vaginal bleeding
o Chills
o Fever
o Painful Menstruation
o Back pain
Term
Endometriosis-
Definition
where the inner lining of the uterus is growing outside of the uterus
Term
Uterine Fibroids-
Definition
Benign tumors in the uterus
 Primary reason for hysterectomy
Term
Endometrial Carcinoma-
Definition
Cancer of the lining of the uterus
Term
Interstitial Cystitis
-What is it?
-s&s
Definition
Inflammation of bladder wall
 Signs and Symptoms
o Urgency and frequency of urination
o Pain
o Pressure
o Poor sleep
o Burning feeling in groin
Term
Vulvodynia
Definition
 Pain of the female external genitalia
 Itching burning, stabbing pain
Term
Levator Ani Syndrome
What is it?
Etiology
Definition
 Spasms of the pelvic floor muscles

 Etiology
o Trauma
o Posture
o Childbirth
o Low back pain
o Sexual abuse
Term
breast cancer
s&s
Definition
-Lump - not painful
o Lump changing shape of breast
o Bleeding of nipple
o Color changes
o Inversion of nipple
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