Term
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Definition
| The CAUSE of disease, either intrinsic/genetic or acquired |
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Term
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Definition
| The mechanism of disease development |
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Term
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Definition
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Term
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Definition
| Decrease in size and function of a cell |
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Term
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Definition
Decreased workload or disuse
Ischemia (as in sickle cell)
Lack of hormonal/neuronal signalling
Malnutrition
Aging |
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Term
| What are terminally differentiated cells? |
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Definition
| Non-replicating- heart, brain |
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Term
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Definition
| Increase in size and function without increasing number of cells |
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Term
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Definition
Increased mechanical demand:
Can be physiologic- like weight lifting, or pathologic- like cardiac muscle in hypertension
Increased endocrine stimulation:
-breast size during lactation
-gravid uterus (estrogen)
-puberty (growth hormone) |
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Term
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Definition
| Increase in NUMBER of cells |
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Term
| What types of cells do not undergo hyperplasia? |
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Definition
| Nerve, heart, skeletal muscle |
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Term
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Definition
| Endocrine or neuronal stimulation |
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Term
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Definition
| faded basophilia (necrosis) |
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Term
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Definition
| nuclear shrinkage (necrosis) |
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Term
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Definition
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Term
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Definition
| Calcium salts as a result of necrosis |
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Term
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Definition
| Ischemia- GHOSTS- hypoxic cell death |
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Term
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Definition
| Blood vessels, kidney- from long standing hypertension- RED |
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Term
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Definition
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Term
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Definition
| Cysteine protease- apoptotic executioners that degrade DNA |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Undigested intracellular lipid (peroxidation) |
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Term
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Definition
| Tyrosine- action of enzyme tyrosinase in response to sun |
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Term
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Definition
Elevated serum calcium - from alkalosis
-kidney- renal failure
-lung- resp probs |
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Term
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Definition
| regulate cell cycle- bind to CDK (cyclin dependent kinases)- can be blocked by inhibitors |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| causes migration and prolif of fibroblasts, SMC, monocytes |
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Term
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Definition
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Term
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Definition
| fibrogenic- increases collagen production |
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Term
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Definition
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Term
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Definition
| measure collagen production |
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Term
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Definition
| basic Fibroblast Growth Factor- ANGIOGENSIS |
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