Term
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Definition
| solid joints, minimal movement |
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Term
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Definition
| cranial sutures, tooth roots |
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Term
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Definition
| also cartilaginous synarthroses, symphyses |
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Term
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Definition
| joint space with wide range of motion. |
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Term
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Definition
| cuboid connective cells that synthesize hyaluronic acid. Lining lacks basement membrane |
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Term
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Definition
| knees and hands in women and hips in men |
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Term
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Definition
| chondrocyte injury, chrondrocytes proliferate and initiate inflammatory changes, then repetitive injury leads to chondrocyte drop out |
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Term
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Definition
| dislodged pieces of cartilage and subchondral bone tumble into the joint forming loose bodies |
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Term
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Definition
| friction burnished exposed bone |
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Term
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Definition
| mushroom-shaped bony outgrowth at the margins of the articular suface in OA. Capped by fibrocartilage |
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Term
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Definition
| deep, achy, worsens with use, morning stiffness, crepitus. Heberden nodes |
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Term
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Definition
| prominent osteophytes at the distal interphalangeal joints, common in women but not men |
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Term
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Definition
| chronic systemic inflammatory disorder. women 3-5 more often. malaise fatigue, symmetrical with small joints first. swollen, warm, stiff. Joint effusions, osteopenia, morning stiffness, nodules |
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Term
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Definition
| inflammatory iniltrate, vascularity due to vasodilations w/ hemosiderin deposits, fibrin covering synovium and floating, accumulation of neutrophils, osteoclastic activity, pannus w/ potential fibrous ankylosis |
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Term
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Definition
| mass of synovium and granulation that grows over the articular cartilage and causes erosion. Can lead to fibrous ankylosis |
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Term
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Definition
| edematous, thickened, hyperplastic synovium; rheumatoid nodules, erosive vessel disease, vasculitis, peripheral neuropathy, ulvers and gangrene. |
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Term
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Definition
| skin subjected to pressure, firm, nontender, fibrinoid necrosis surrounded by histiocytes/macrophages |
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Term
| Juvenile Idiopathic (Rheumatoid) Arthritis Subsets |
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Definition
| systemic, oligoarthritis, RF+ polyarthritis, RF- polyarthritis, enthesitis, psoriatic, undifferentiated |
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Term
| Juvenile Idiopathic (Rheumatoid) Arthritis VS RA |
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Definition
More: oligoarthritis, systemic disease, large joints, ANA seropositive.
Less: Nodules and RF |
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Term
| Systemic Juvenile Arthritis |
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Definition
| abrupt onset common, fevers, skin rash, hepatosplenomegaly, serositis |
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Term
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Definition
| fouror fewer joints in the first 6 months without psoriasis. asymmetric, <6 years, iridocylitis and ANA+ |
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Term
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Definition
| similar to the adult form. > 5 joints in first 6 months. |
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Term
| Enthesitis related arthritis |
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Definition
| male children younger than 6 years, HLA-B27. Affects tendoliganemtous insertions sites and lower extremities |
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Term
| Undifferentiated juvenile arthritis |
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Definition
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Term
| Seronegative Spondyloarthropathies |
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Definition
| Ankylosing spondyloarthritis, Reiter Syndrome, Enteritis-Associated Arthritis, Psoriatic Arthritis |
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Term
| Ankylosing SPondyloarthritis |
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Definition
| articular cartilage destruction by chronic synovitis. 2/3 decades. Male predominance. HLA-B27 more common. Genes: ARTS1, IL23R |
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Term
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Definition
| Triad: arthritis, nongonococcal urethritis/cervicitis, and conjunctivitis. Men 20-30s, HLA-B27. sausage finger and ossification. aortic regurgitation. |
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Term
| Enteritis-Associated Arthritis |
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Definition
| GI infection: Yersinia, Salmonella, Shigella, Campylobacter. Lipopolysaccharides. Knees and ankles. lasts about a year |
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Term
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Definition
| chronic inflammatory arthropathy. HLA-B27 and Cw6. ages 30-50. Sausage-like finter, interphalangeal joints, sacroiliac and spinal. |
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Term
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Definition
| 90 of nongonococcal cases are a single joint, most often the knee. Gonococcus, staphylococcus, streptococcus, H. influenzae, gram-negative bacilli. Fever, leukocytosis, high sed rate. Axial for drug addicts. |
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Term
| H. influenzae Arteritis Demographic |
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Definition
| predominantly children under 2 |
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Term
| S. aureus Arteritis Demographic |
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Definition
| older children and adults |
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Term
|
Definition
| late adolescence and young adulthood. Mainly sexually active young women. |
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Term
| Salmonella Arteritis Demographic |
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Definition
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Term
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Definition
| gradual progressive pain. synovium may grow as a pannus. Obliteration of the joint space. Weight-bearing joints most affected. |
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Term
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Definition
| spirochete Borrelia burgdorferi, Ixodes ricinus ticks. Initial infection of the skin. Arthritis in late disease. Onion-skin thickening. Resemble rheumatoid arthritis. Silver stains. HLA-DR may result in autoimmunity. |
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Term
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Definition
| Alphavirus, parvovirus B19, rubella, EBV, Hep B/C, HIV (autoimmune) |
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Term
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Definition
| URAT1: urate transporter gene. HGPRT: salvage pathway. acute arthritis, tophaceous arthritis, tophi, neutrophilic iniltrate. May encrust surfaces in chronic. 20% die of renal failure. |
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Term
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Definition
| hallmark. articular cartilage, ligaments, endons, soft tissues. Negatively birefringent crystals |
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Term
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Definition
| Only in males. HGPRT deficiency. Triad of mental retardation, hyperuricemia, self-mutilation |
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Term
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Definition
| deposition in the renal medullary intersitium. May cause pyelonephritis |
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Term
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Definition
| Calcium Pytophosphate Crystal deposition disease |
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Term
| Calcium pyrophosphate crystal deposition disease (Pseudogout) |
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Definition
| Linked to ANKH gene (transmembrane pyrophosphate transport channel) crystals first in articular matrix. phagocytosed by macrophages which activate NALP3 inflammasome. Neutrophils cause inflammation. Chalky-white friable deposits. Oval blue-purple aggregates in H&E. weakly birefringent |
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