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**Pathology 24 Parathyroid
Robbins and Cotran
17
Pathology
Graduate
03/25/2011

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Cards

Term
Chief Cells
Definition
light to dark pink. polygonal, PTH
Term
Oxyphil Cells
Definition
water-clear due to glycogen, acidophilic, packed with mitochondria
Term
PTH effects
Definition
increased renal Ca reabsorption, Vit D kidney conversion, urinary phosphate excretion, GI Ca absorption
Term
Most common cause of clinically apparent hypercalcemia
Definition
Malignancy
Term
Osteoprotegerin
Definition
decoy receptor of RANKL which siphons off excess ligand
Term
MEN-2
Definition
activating mutation of RET tyrosine kinase inhibitor
Term
Familial hypocalciuric hypercalcemia
Definition
autosomal-dominant, decreased Ca sensitivity, calcium-sensing receptor (CASR) on 3q
Term
Parathyroid Adenoma Genetics
Definition
Pericentric 11q inversion including Cyclin D1 placed near the PTH gene regulator. Also MEN1 (11q13)
Term
Parathyroid Adenomas
Definition
compressed, non-neoplastic capsule, endocrine atypia, abundant water-clear cells
Term
Endocrine Atypia
Definition
bizarre and pleomorphic nuclei
Term
Parathyroid carcinomas
Definition
gray-white, irregular masses, invasion is the only true marker
Term
Parathyroid Cancer symptoms
Definition
Bonen disease, nephrolithiasis, GI disturbances, depression, lethargy, seizures, weakness, fatigue, cardiac manifestations
Term
Most common cause of secondary parathyroidism
Definition
renal failure
Term
Hypoparathyroidism most common cause
Definition
surgery
Term
Hypoparathyroid genetic causes
Definition
Autoimmune in autoimmune polyendocrine syndrome type 1 (APS1) with AIRE mutation, CASR, familial isolated hypoparathyroidism (FIH) is dominant in precursor gene and recessive with GCM2
Term
Chvostek sign
Definition
tapping along the facial nerve induces contractions
Term
Trousseau sign
Definition
carpal spasms produced by occlusion of the circulation to the forearm
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