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Pathology 184 - 197
Robbins and Cotran
28
Pathology
Graduate
04/05/2011

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Cards

Term
TCR
Definition
T-cell receptor that is antigen-specific
Term
alpha-beta TCR
Definition
95% of TCRs. Recognizes antigens presented on MHC molecules.
Term
Rag-1/2
Definition
Genes that code the enzyme that mediates rearrangement of antigen receptor genes
Term
TCR signal is transduced by
Definition
CD3 and zeta proteins
Term
gama-delta TCR
Definition
recognizes peptides, lipids, and small molecules without MHC proteins
Term
NK-T cells
Definition
express NK cells markers. Limited diversity of TCRs, recognize glycolipids
Term
B-cells surface antibodies
Definition
IgM and IgD
Term
B-cells signal transduction for antigens
Definition
Ig-alpha and Ig-beta
Term
B-cells transducers
Definition
Ig-alpha, Ig-beta, and CD40, Fc receptor, CR2/CD21
Term
NK cells
Definition
azurophilic granules, also large granular lymphocytes. Kill infected and tumor cells. CD16/56. ADCC. NKG2D receptors. IL-2 and IL 15 cause proliferation and IL-12 activates killing
Term
ADCC
Definition
Anti-body-dependent cell-mediated cytotoxicity
Term
B-cells in lymph nodes
Definition
Peripheral in follicles
Term
T-cells in lymph nodes
Definition
Central in paracortex, adjacent to the follicles
Term
HEVs
Definition
High endothelial venules: Naive T cells enter these to T-cell zones
Term
MHC1
Definition
All nucleated cells + platelets. HLA-A/B/C. Heavy alpha(1/2/3) and smaller beta2. Cleft between alpha1/2. Displays cytoplastic proteins
Term
MHC2
Definition
Mainly of phagocytosing cells. HLA-D(P/Q/R). alpha(1/2) and beta(1/2) with cleft between alpha1 and beta1. beta2 binds CD4
Term
HLA-B27
Definition
ankylosing spondylitis, arthropathies, acute anterior uveitis
Term
DR4
Definition
RA, DM
Term
DR3
Definition
chronic active hepatitis, Sjogren, DM
Term
Innate cytokines
Definition
TNF, IL-1, IL-12, IFNgamma, chemokines
Term
Adaptive Cytokines
Definition
IL-2, IL-4, IL-5, IL-17, IFN-gamma
Term
T-cell costimulators
Definition
B7 proteins: CD80 and CD86. Recognized by CD28 on naive cells
Term
CD40
Definition
Activates macrophages and B-cells when bound by C40L
Term
IL-4
Definition
stimulates B-cells
Term
IL-5
Definition
Activates eosinophils
Term
Antibodies stimulated by polysaccharides and lipids
Definition
IgM
Term
Antibodies stimulated by proteins
Definition
IgG, IgA, IgE
Term
Isotype switching cytokines
Definition
IFN-gamma and IL-4
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