Term
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Definition
| T-cell receptor that is antigen-specific |
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Term
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Definition
| 95% of TCRs. Recognizes antigens presented on MHC molecules. |
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Term
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Definition
| Genes that code the enzyme that mediates rearrangement of antigen receptor genes |
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Term
| TCR signal is transduced by |
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Definition
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Term
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Definition
| recognizes peptides, lipids, and small molecules without MHC proteins |
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Term
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Definition
| express NK cells markers. Limited diversity of TCRs, recognize glycolipids |
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Term
| B-cells surface antibodies |
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Definition
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Term
| B-cells signal transduction for antigens |
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Definition
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Term
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Definition
| Ig-alpha, Ig-beta, and CD40, Fc receptor, CR2/CD21 |
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Term
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Definition
| azurophilic granules, also large granular lymphocytes. Kill infected and tumor cells. CD16/56. ADCC. NKG2D receptors. IL-2 and IL 15 cause proliferation and IL-12 activates killing |
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Term
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Definition
| Anti-body-dependent cell-mediated cytotoxicity |
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Term
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Definition
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Term
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Definition
| Central in paracortex, adjacent to the follicles |
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Term
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Definition
| High endothelial venules: Naive T cells enter these to T-cell zones |
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Term
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Definition
| All nucleated cells + platelets. HLA-A/B/C. Heavy alpha(1/2/3) and smaller beta2. Cleft between alpha1/2. Displays cytoplastic proteins |
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Term
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Definition
| Mainly of phagocytosing cells. HLA-D(P/Q/R). alpha(1/2) and beta(1/2) with cleft between alpha1 and beta1. beta2 binds CD4 |
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Term
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Definition
| ankylosing spondylitis, arthropathies, acute anterior uveitis |
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Term
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Definition
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Term
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Definition
| chronic active hepatitis, Sjogren, DM |
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Term
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Definition
| TNF, IL-1, IL-12, IFNgamma, chemokines |
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Term
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Definition
| IL-2, IL-4, IL-5, IL-17, IFN-gamma |
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Term
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Definition
| B7 proteins: CD80 and CD86. Recognized by CD28 on naive cells |
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Term
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Definition
| Activates macrophages and B-cells when bound by C40L |
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Term
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Definition
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Term
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Definition
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Term
| Antibodies stimulated by polysaccharides and lipids |
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Definition
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Term
| Antibodies stimulated by proteins |
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Definition
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Term
| Isotype switching cytokines |
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Definition
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