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Patho Ch. 28
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27
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Undergraduate 4
04/25/2012

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Term
nephron
Definition
functional part of the kidney
tubular structure
Term
cortical nephron
Definition
only within cortex
Term
juxtamedullary nephron
Definition
portion within the medulla
Term
cortex
Definition
outer layer containing most of nephron
Term
medulla
Definition
consists of triangular-shaped wedges (pyramids) which are separated from each other by areas of cortical tissue called renal columns
Term
What do the columns of Bertini contain?
Definition
collecting ducts
Term
What do the collecting ducts do?
Definition
enter into calyces which lead into renal pelvis and then into ureter at the hilus
Term
What is found in the wall of afferent arteriole?
Definition
modified smooth muscle cells
Term
What is found in the wall of distal tubule?
Definition
narrowed macula densa cells
Term
What's the function of blood flow?
Definition
releases renin when renal blood flow is depressed
Term
What does renin do?
Definition
ultimately triggers formation formation of angiotensin II which induces vasoconstriction and promotes release of aldosterone
Term
What does aldosterone do?
Definition
stimulates sodium reabsorption which causes increase water reabsorption and thus plasma volume is increased
Term
What does increased plasma volume to do blood pressure?
Definition
elevates BP which facilitates reduction of renal ischemia
Term
What are the 3 steps of urine formation?
Definition
filtration, reabsorption, secretion
Term
filtration
Definition
movement of plasma ultrafiltrate out of glomerulus into Bowman's capsule
Term
filtration pressure
Definition
effective force driving fluid out of glomerulus
Term
glomerular blood pressure
Definition
pushes fluid out of glomerulus into Bowman's capsule
normally measures 60 mm Hg
Term
glomerular colloid osmotic pressure
Definition
serves to draw fluid out of Bowman's capsule back into glomerulus
normal ranges around 32 mm Hg
Term
bowman's capsule pressure
Definition
resist movement of fluid out of glomerulus into Bowman's capsule
normally 18 mm Hg
Term
What does glomerular blood pressure depend on?
Definition
volume of blood entering the glomerulus
Term
Autoregulation mechanisms
Definition
reflex responses that guard against rapid changes in glomerular blood pressure
Term
What does dilation of afferent arteriole promote?
Definition
increase in glomerular blood volume
Term
What does vasoconstriction of afferent arteriole depress?
Definition
flow of blood through glomerulus
Term
Glomerular colloid osmotic pressure
Definition
varies primarily with plasma concentration of large protein molecules
Term
What influence surinary composition?
Definition
status of glomerular membranei
Term
What's reabsorption provide?
Definition
means for selectively retaining certain substances that initially filter into Bowman's capsule
Term
What does 65% of reabsorption take place?
Definition
PCT--proximal convulated tubule
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