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Path 2
Inflammatory mediators
23
Pathology
Professional
01/29/2012

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Cards

Term
Histamine and serotonin
Definition
Source: Mast cells and platelets
Increase vascular leakage
Term
Bradykinin
Definition
Source: Plasma substrate
Increase vascular leakage
PAIN
Term
C3a
Definition
Source: Plasma protein via liver
Increase vascular leakage
OPSONIC FRAGMENT (C3b)
Term
C5a
Definition
Source: Macrophages
Increase vascular leakage
Increase chemotaxis
LEUKOCYTE ADHESION AND ACTIVATION
Term
Prostaglandins
Definition
Source: Mast cells from phspholipids
Potentiate other mediators
VASODILATION, PAIN, FEVER
Term
Leukotriene B4
Definition
Source: Leukocytes
Increase chemotaxis
LEUKOCYTE ADHESION AND ACTIVATION
Term
Leukotriene C4, D4, E4
Definition
Source: Leukocytes, Mast Cells
Increase vascular leakage
BRONCHOCONSTRICTION, VASOCONSTRICTION
Term
Oxygen Metabolites
Definition
Source: Leukocytes
Increase vascular leakage
ENDOTHELIAL DAMAGE, TISSUE DAMAGE
Term
PAF- Platelet Aggregation Factor
Definition
Source: Leukocytes and Mast Cells
Increase vascular leakage and chemotaxis
BRONCHOCONSTRICTION, LEUKOCYTE PRIMING
Term
IL-1 and TNF
Definition
Source: Macrophages, etc.
Increase chemotaxis
ACUTE ACUTE ACUTE ACUTE ACUTE-PHASE
ENDOTHELIAL ACTIVATION
Term
Chemokines
Definition
Source: Leukocytes, etc.
Increase chemotaxis
LEUKOCYTE ACTIVATION
Term
Nitric Oxide
Definition
Source: Macrophages, endothelium
Increase vascular leakage and chemotaxis
VASODILATION, CYTOTOXICITY
Term
What mediators are involved in vasodilation?
Definition
Prostaglandins (Prostacyclin)
Nitric Oxide (maintains vasodilation)
Histamine (starts vasodilation)
Term
What mediators are involved in increasing vascular permeability?
Definition
Vasoactive Amines
C3a and C5a
Bradykinin
Leukotriens C4, D4, E4
PAF
Substance P
Term
What mediators are involved in chemotaxis, leukocyte recruitment, and activation?
Definition
C5a
Leukotriene B4
Chemokines
IL-1,TNF
Bacterial products
Term
What mediators are involved in fever?
Definition
IL-1, TNF
Prostaglandins
Term
What mediators are involved in pain?
Definition
Prostaglandins
Bradykinin
Term
What mediators are involved in tissue damage?
Definition
Neutrophils and macrophage lysosomal enzymes
Oxygen metabolites (ROS)
Nitric Oxide
Term
What is the role of P-selectin?
Definition
Rolling (neutrophils, monocytes, T lymphocytes)
Term
What is the role of E-selectin?
Definition
Rolling and adhesion (neutrophils, monocytes, T lymphocytes)
Term
What is the role of L-selectin?
Definition
Rolling (neutrophils, monocytes)
Term
What is the role of ICAM-1?
Definition
Adhesion, arrest, transmigration (neutrophils, monocytes, lymphocytes)
Term
What is the role of VCAM-1?
Definition
Adhesion (eosinophils, monocytes, lymphocytes)
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