Term
| Three types of cytoskeletal filaments are very common to eucaryotic cells and are fundamental to the spatial organization of cells. They are actin filaments, intermediate filaments and ________________ |
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Definition
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Term
| Microtubules can quickly rearrange themselves to form a _________________ during cell division |
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Definition
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Term
| Anticancer drugs are organized into two groups both based on severely disrupting the mitotic spindle. |
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Definition
1) Those that cause depolymerization (dissassembly) of tubulin microtubules to predominant over assembly
2)Those that result in stabilization of tubulin polymers, enabling assessmbly to predominate |
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Term
| The medicinal benefits of the periwinkly plant is formerly know as __________ |
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Definition
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Term
| The two major vinca alkaloids are_________________ and _______________ |
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Definition
Vinblastine (Velban)
Vincristine (Oncovin) |
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Term
| What occurs when a vinca compound binds to the tubulin dimer? |
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Definition
| The normal dynamic steady state is altered, allowing disassembly to predominate over assembly therefore blocking mitosis |
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Term
| Which drug is used for pediatric leukemias? |
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Definition
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Term
| Which drug is used in adult lymphomas |
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Definition
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Term
| Which drug is used in testicular carcinomas? |
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Definition
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Term
| Which drug is used in lymphomas such as Hodgkin's disease? |
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Definition
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Term
| The two major vinca alkaloids are vinblastine and vincristine. What is the third member of this class? |
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Definition
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Term
| ___________ produces severe neurological toxicity |
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Definition
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Term
| Which drug is never to be injected intrathecally because of its devastating neurotoxic effects which are usually fatal? |
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Definition
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Term
| What drug consists of an estrogen linked to a nitrogen mustard? |
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Definition
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Term
| Estramustine is effective against hormone refractory and metastatic __________ cancers |
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Definition
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Term
| Which drug was first isolated from the bark of the western yew? |
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Definition
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Term
| Members of this class all contain the taxane ring system and are referred to as _______ or __________ |
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Definition
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Term
| What occurs when a taxane binds to the tubulin dimer? |
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Definition
| The normal dynamic steady state is altered, allowing assembly to predominate over disassembly |
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Term
| ____________ is used in metastatic ovarian and breast cancers |
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Definition
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Term
This drug has very limited solubility in water and must be administered by infusion in a vehicle of 50% ethanol and 50% polyethoxylated castor oil.
Hypersenstiivity reactions are relatively common |
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Definition
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Term
| Which drug is used in drug eluting coronary stents? |
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Definition
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Term
| Which durg is used to prevent in-stent restenosis? |
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Definition
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Term
| Which drug is a semisynthetic analog of paclitaxel that is approved for metastatic breast cancer and also used in non small cell lung cancer ? |
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Definition
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Term
| Which drug is adminsitered in polysorbate 80, and therefore has __________ hypersensitivity reactions. |
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Definition
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Term
| What is the newest taxane derivative approved for the treatment of advanced prostate cancer? |
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Definition
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Term
| Which drug promotes tubulin polymerization and microtubule stabilization? |
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Definition
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