Term
Methylphenidate and Amphetamines
MOA??
Tx: ADHD, ADD
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Definition
Release catecholamine and block uptake 1
S/Es: depression, insomnia, decreased appetite and linear growth rate |
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Term
phentolamine, prazosin, phenoxybenzamine
=3 Ps |
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Definition
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Term
Phentolamine/PBZ ____ HR via baroreflex
Prazosin _____ HR |
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Definition
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Term
What is the major S/E of alpha blocker? |
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Definition
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Term
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Definition
blocks α1a receptors in the GU tract in pts w/ BPH to enhance voiding |
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Term
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Definition
Phentolamine --> ↓BP (EPI reversal) |
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Term
Nifedipine & amlodipine have a greater ___ BP than diltiazem & verapamil |
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Definition
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Term
Verapamil and Distiazem ___ AV conduction via ____ in ERP and HR |
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Definition
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Term
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Definition
↑ BP, ↑SNS activity via CNA, presynaptic enhancement of NE release, blocks NE uptake, release ADH, release of aldosterone, decreases mesenteric BF. |
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Term
ACE inhibitors have what effect on TPR, BP, HR, CO |
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Definition
↓TPR and BP
NO change on HR, and CO |
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Term
What causes the cough of ACE inhibitors |
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Definition
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Term
What is a type of carbonic anhydrase inhibitor? |
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Definition
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Term
What drug enhances digoxin toxicity via hypokalemia? |
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Definition
Furosemide & ethacrynic acid
and the thiazides |
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Term
What is one main difference btw the loop diuretics (furosemid) and thiazides (HCTZ) in regards to Ca+? |
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Definition
HCTZ actually ↓excretion of CA+ in hypercalcinuria --> used to ↓ formation of kidney stones. |
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Term
What class of drugs?
Amiloride, Triamterene, and Spironolactone? |
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Definition
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Term
Aldo antagonist, partial agonist at androgen/progesterone receptors |
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Definition
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Term
Main effects of digoxin in the heart: |
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Definition
1) Positive inotropic effect --> ↑SV, and ↑CO
2) Increase Vagal tone --> ↓HR, atrial contraction, and AV node |
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Term
On what phase or the AP cycle does quinidine work on? |
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Definition
↓ Phase 4 --> decrease automaticity
↓ phase 0 --> ↓conduction velocity and widen the QRS |
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Term
Lidocaine
what phase and why
what for |
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Definition
↓Phase 4 --> to prevent automaticity
tx for PVCs |
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Term
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Definition
phase 3
inhibits outward K current --> delays repolarization and ↑APD and ERP in atria, AV node |
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Term
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Definition
Cardiovert a.fib and a.flutter to sinus rhythm
*** main S/E torsade de pointes |
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Term
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Definition
↓phase 4 --> decreases automaticity (blocks Na+) channels
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Term
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Definition
acute (i.v.) and recurrent (p.o) ventricular tachycardia/fibrillation |
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Term
Verapamil and Beta-blockers
Tx for what? |
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Definition
AVNRT
bc: ↓HR, ↓conduction velocity, ↑ERP
myocardium: ↓dp/dt, ↓CO |
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