Term
| 4 Aspects of Neuro Pathology |
|
Definition
1. Localization is important (neoplasm in nonvital area v. benign cyst in vital area)
2. similarities to other body parts (e.g. abscess can form)
3. special manifestations of generalized disease (hypertension --> intracerebral hemorrhage (not presented anywhere else)
4. disease process specific to CNS (e.g. multiple sclerosis) |
|
|
Term
| Examples of diseases of specific CNS systems |
|
Definition
| amytrophic lateral sclerosis, acute poliomyelitis, Parkinson's, neurosyphilis (selective vulnerability due to shared features) |
|
|
Term
| example of ubiquitous CNS diseases |
|
Definition
| every neuron involved - lysosomal storage diseases (tay-sachs) |
|
|
Term
|
Definition
| Myelin undergoes degeneration distally as it requires complex lipids - can see linear arrays of axonal and myelin debris with macrophages. |
|
|
Term
| When do you see red neurons? |
|
Definition
| Acute ischemic injury 2˚ to hypoxia/hypoglycemia |
|
|
Term
| What pigment in the brain is common in elderly, associated with wear and tear and oxidative injury? |
|
Definition
|
|
Term
| A newborn lacking conjugation enzymes in liver, common in hemolytic anemias, can have what? |
|
Definition
| Kernicterus (unconjugated bilirubin accumulating in brain) |
|
|
Term
| HSV can present with what intracellular inclusions? |
|
Definition
|
|
