| Term 
 
        | Trade Name for Streptokinase |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Streptokinase--drug class |  | Definition 
 
        | Fibrinolytic (thrombolytic enzyme) |  | 
        |  | 
        
        | Term 
 
        | Streptokinase--Mechanism of Action |  | Definition 
 
        | Converts plasminogen to plasmin, which aids in the dissolution of blood clots. |  | 
        |  | 
        
        | Term 
 
        | Streptokinase--Contraindications |  | Definition 
 
        | -Active internal bleeding -Cerebrovascular accident w/in 2 mos
 -Intracranial or intraspinal surgery
 -Severe, uncontrolled HTN (syst > 180, diast > 110)
 -Significant trauma (sp. head)
 -Prolonged CPR
 |  | 
        |  | 
        
        | Term 
 
        | Streptokinase--Indications |  | Definition 
 
        | -AMI -Pulmonary Embolism
 -DVT (deep venous thrombosis)
 -Arterial Thrombosis
 -Embolism
 |  | 
        |  | 
        
        | Term 
 
        | Streptokinase--Precautions |  | Definition 
 
        | -May cause severe bleeding -Use one IV line exclusively for admin
 |  | 
        |  | 
        
        | Term 
 
        | Streptokinase--Available Forms |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | -AMI, infuse 1.5 mil units/45 mL w/in 60 mins -Embolism/Thrombosis, admin loading dose of 250,000 units via IV into a peripheral vein over 30 min
 |  | 
        |  | 
        
        | Term 
 
        | How does streptokinase come prepared? |  | Definition 
 
        | 250,000 or 750,000 or 1.5 million units powder in a vial that must be reconstituted |  | 
        |  | 
        
        | Term 
 
        | How is streptokinase administered? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Pediatric dosage of streptokinase. |  | Definition 
 
        | Safety in pediatric Pts has not been established. |  | 
        |  | 
        
        | Term 
 
        | Side-effects of streptokinase. |  | Definition 
 
        | -Bleeding -Allergic rxn
 -HypoTN
 -Chest pain
 -Reperfusion dysrhythmias
 -Abdominal pain
 |  | 
        |  | 
        
        | Term 
 
        | Streptokinase interacts with... |  | Definition 
 
        | -Anticoagulants -Agents that alter platelet fxn (aspirin, NSAIDs)
 -Thrombolytic agents
 -Agents that alter coagulation
 |  | 
        |  | 
        
        | Term 
 
        | Trade name for t-PA (altepase). |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | Same as streptokinase, converts plasminogen to plasmin. |  | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | Indications for t-PA admin. |  | Definition 
 
        | -Acute ischemic stroke -AMI caused by occlusion
 -Pulmonary thrombosis/embolism
 |  | 
        |  | 
        
        | Term 
 
        | Contraindications for t-PA admin. |  | Definition 
 
        | -Intracranial hemorrhage or Hx thereof -Recent intraspinal or intracranial surgery
 -Serious head trauma
 -Previous stroke
 -Hx of severe HTN
 -Seizure w/ stroke
 -Active internal bleed
 -Trauma surgery w/in 10 days
 -Pt > 75 y/o
 |  | 
        |  | 
        
        | Term 
 
        | Precaution of t-PA admin. |  | Definition 
 
        | Recommended min. of 3 patent IV sites prior to admin |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | One vial powder to be reconstituted with one vial sterile water. |  | 
        |  | 
        
        | Term 
 
        | How does t-PA come prepared? |  | Definition 
 
        | 100 mg, 50 mg, or 2 mg/vial |  | 
        |  | 
        
        | Term 
 
        | How is t-PA administered? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of t-PA for cardiac problems? |  | Definition 
 
        | 0.9 mg/kg infused over 60 min w/ 10% of total dose pushed as an IV bolus over 1 min (MTD 100 mg). |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of t-PA for suspected CVA? |  | Definition 
 
        | 15 mg IV bolus, followed by 0.75 mg/kg infusion over 30 min |  | 
        |  | 
        
        | Term 
 
        | What is the ped dosage of t-PA? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the side effects of t-PA? |  | Definition 
 
        | -HypoTN -Bleeding
 -Fever
 -NV
 -Easy bruising/bleeding
 |  | 
        |  | 
        
        | Term 
 
        | What are the signs of t-PA toxicity? |  | Definition 
 
        | -Syncope -Vision changes
 -Coughing/vomiting blood
 -Slurred speech
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | Do not use with other anticoagulants (ex. Warfarin, Aspirin, etc.) |  | 
        |  | 
        
        | Term 
 
        | This is the generic name for aspirin. |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | Prevents the formation of thromboxane and inhibits the production of prostaglandins. |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | -Antiplatelet (inhibits the production of thromboxane) -Analgesic (blocks the synthesis of prostaglandins and prevents sensitization of pain receptors)
 -Antipyretic (lowers temp via vasodilation)
 |  | 
        |  | 
        
        | Term 
 
        | What are the indications of aspirin admin? |  | Definition 
 
        | -Ischemic chest pain -Stroke (?)
 |  | 
        |  | 
        
        | Term 
 
        | Contraindications of aspirin admin. |  | Definition 
 
        | -Reye's -Pt w/ GI bleed
 -Alcoholics
 -Hemophilia
 -Nose polyps
 -VonWillebrand's
 -Breast feeding
 -Blood clotting disorders
 |  | 
        |  | 
        
        | Term 
 
        | What are the precautions of aspirin admin? |  | Definition 
 
        | Lethal dose achieved at 400 mg/kg |  | 
        |  | 
        
        | Term 
 
        | Aspirin is available in what forms? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of aspirin for ischemic chest pain? |  | Definition 
 
        | 324 mg, chewed and swallowed |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 15-30 min after ingestion |  | 
        |  | 
        
        | Term 
 
        | Side effects of aspirin admin? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the signs of aspirin toxicity? |  | Definition 
 
        | -"Classic" signs are tachycardia, febrile, and tachypnea -Hepatotoxicity
 -Anemia
 -Forms concentrations in the stomach
 |  | 
        |  | 
        
        | Term 
 
        | What is the generic name of nitroglycerine? |  | Definition 
 
        | Nitrostat, Tridil (IV form) |  | 
        |  | 
        
        | Term 
 
        | Nitro is what class of drugs? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the site of action of Nitro? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | Breaks down Nitric Oxide (NO) |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | -Relaxes smooth muscle -Decreases preload/afterload
 -Dilates coronary arteries
 |  | 
        |  | 
        
        | Term 
 
        | Indications for nitro admin. |  | Definition 
 
        | -Ischemic chest pain -Pulmonary edema (incl. CHF)
 -HTN crisis
 |  | 
        |  | 
        
        | Term 
 
        | Contraindications of nitro admin. |  | Definition 
 
        | -HypoTN -Bradycardia
 -ED drugs w/in 24 hr
 |  | 
        |  | 
        
        | Term 
 
        | Precautions of nitro admin. |  | Definition 
 
        | Pt w. inferior (R. sided) AMI |  | 
        |  | 
        
        | Term 
 
        | Nitro is available in what forms? |  | Definition 
 
        | Spray, tablet, solution, paste |  | 
        |  | 
        
        | Term 
 
        | How does nitro come prepared? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | Sublingual, oral, IV, topical |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of nitro for chest pain? |  | Definition 
 
        | 0.4 mg sublingual, q 5 min (as long as systolic stays > 90 mm Hg) |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of nitro for edema? |  | Definition 
 
        | 0.4-0.16 mg sublingual q 5 min (as long as diastolic stays > 100 mm Hg) |  | 
        |  | 
        
        | Term 
 
        | What is the pediatric dosage of nitro? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the onset, and peak effect of nitro? |  | Definition 
 
        | 1-4 min onset, 8 min peak |  | 
        |  | 
        
        | Term 
 
        | What are the side-effects of nitro admin? |  | Definition 
 
        | -HA -HypoTN
 -Reflex tachycardia
 |  | 
        |  | 
        
        | Term 
 
        | If you admin nitro, and the Pt complains of a throbbing headache, it means... |  | Definition 
 
        | The Pt has received a therapeutic level of nitro (no more is needed). |  | 
        |  | 
        
        | Term 
 
        | What is the sign of Nitro toxicity? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of morphine for pain? |  | Definition 
 
        | 2-4 mg slow IV over 1-5 min every 5-30 min, titrate to effect |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of morphine for STEMI? |  | Definition 
 
        | 2-4 mg IV, may give additional doses at 2-8 mg @ 15 min intervals |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of morphine for NSTEMI? |  | Definition 
 
        | 1-5 mg IV, only if symptoms are not relieved by nitrates, or if symptoms reoccur. |  | 
        |  | 
        
        | Term 
 
        | What is the pediatric dosage of morphine? |  | Definition 
 
        | 0.1-0.2 mg/kg IV, MTD 15 mg |  | 
        |  | 
        
        | Term 
 
        | What is the trade name for adenosine? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Adenosine belongs to what class of meds? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | •	Slows tachycardias associated with AV node via modulation of the autonomic NS •	Slows conduction through the AV node, and blocks reentry pathways
 |  | 
        |  | 
        
        | Term 
 
        | Indications for adenosine use. |  | Definition 
 
        | •	SVTs (including WPW) refractory to vagal maneuvers •	Stable monomorphic wide complex tachycardia
 |  | 
        |  | 
        
        | Term 
 
        | Contraindications for adenosine use. |  | Definition 
 
        | •	2nd or 3rd Degree HB •	Sick sinus syndrome
 •	Known AFib/AFlut (won’t harm, but won’t fix)
 •	Irregular wide-complex tachycardias
 |  | 
        |  | 
        
        | Term 
 
        | Precautions for adenosine use. |  | Definition 
 
        | May cause refractory bronchospasm (so use cautiously in COPD and asthma Pts) |  | 
        |  | 
        
        | Term 
 
        | How does adenosine come prepared? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of adenosine? |  | Definition 
 
        | 6 mg rapid IV bolus followed by 20 mL flush and extremity elevation. |  | 
        |  | 
        
        | Term 
 
        | How may adenosine be readministered? |  | Definition 
 
        | If no response in 1-2 min to initial bolus, admin 12 mg. |  | 
        |  | 
        
        | Term 
 
        | What is the onset of adenosine? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the duration of adenosine? |  | Definition 
 
        | 10 sec (so must administer very quickly, usually simultaneously with partner pushing NS flush) |  | 
        |  | 
        
        | Term 
 
        | What are the side effects of adenosine? |  | Definition 
 
        | •	Flushing •	Chest pain
 •	Dyspnea
 •	HA
 •	Diaphoresis
 •	Metallic taste
 •	Dizziness
 •	Lightheadedness
 •	Numbness
 •	NV
 •	Palpitations
 |  | 
        |  | 
        
        | Term 
 
        | What are the interactions of adenosine? |  | Definition 
 
        | •	Additive effects—digoxin, CBBs •	Antagonistic effects--methylxanthines
 |  | 
        |  | 
        
        | Term 
 
        | What are the special considerations of adenosine admin? |  | Definition 
 
        | •	Consider having partner admin flush for speed purposes •	Admin very rapidly
 •	Have EKG printout going before and during push
 |  | 
        |  | 
        
        | Term 
 
        | Adenosine should be administered for... |  | Definition 
 
        | -SVTs (incl. WPW) -Monomorphic Wide Complex Tachycardia
 |  | 
        |  | 
        
        | Term 
 
        | Trade name for amiodarone. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Drug class of amiodarone. |  | Definition 
 
        | Antiarrhythmic (Class III) |  | 
        |  | 
        
        | Term 
 
        | Indications for amiodarone admin. |  | Definition 
 
        | •	Recurrent VFib •	Sustained VTach
 •	Refractory VTach/VFib
 |  | 
        |  | 
        
        | Term 
 
        | Contraindications for amiodarone. |  | Definition 
 
        | •	HypoTN •	Cardiogenic Shock
 •	Bradycardia
 •	2nd or 3rd Degree HB
 •	Do not use w/ drugs that prolong QT intervals
 |  | 
        |  | 
        
        | Term 
 
        | How does amiodarone come prepared? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | How is amiodarone administered? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of admiodarone for cardiac arrest? |  | Definition 
 
        | 300 mg/20-30 mL NS, readmin 150 mg @ 3-5 min with MTD 450 mg |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of admiodarone for VTach/VFib? |  | Definition 
 
        | 150 mg over 10-15 min, q @ 10 min |  | 
        |  | 
        
        | Term 
 
        | What is the onset of amiodarone? |  | Definition 
 
        | 5-15 min, peaks at 30-45 min |  | 
        |  | 
        
        | Term 
 
        | What is the duration of amiodarone? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the side-effects of amiodarone admin? |  | Definition 
 
        | •	Vasodilation •	Hepatoxicity
 •	HypoTN
 •	Prolonged QT
 •	Bradycardia
 •	VTach/VFib
 •	Heart blocks
 |  | 
        |  | 
        
        | Term 
 
        | What are the interaction concerns of amiodarone admin? |  | Definition 
 
        | •	May increase Digoxin levels and lead to Digoxin toxicity •	May cause HypoTN, bradycardia, and decreased CO when concurrently used with Fentanyl
 |  | 
        |  | 
        
        | Term 
 
        | What is the trade name of atropine sulfate? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What classes of drugs does atropine belong to? |  | Definition 
 
        | •	Anticholinergic •	Parasympatholytic
 •	Antimuscarinic
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | •	Inhibits ACh at postganglionic sites in smooth muscle •	Blocks vagal nerve stimulation (vagalytic)
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | •	Increase HR •	Decrease GI and respiratory secretions
 |  | 
        |  | 
        
        | Term 
 
        | What are the indications for atropine admin? |  | Definition 
 
        | •	Symptomatic sinus bradycardia •	Low-degree HB (1st Degree/2nd Degree Type I)
 •	Pesticide poisoning (organophosphates)
 |  | 
        |  | 
        
        | Term 
 
        | What are the contraindications for atropine admin? |  | Definition 
 
        | •	NAG •	Acute hemorrhage
 •	Tachycardia
 •	Destructive disease of the GI
 |  | 
        |  | 
        
        | Term 
 
        | What are the precautions of atropine admin? |  | Definition 
 
        | •	Intra-abdominal infections •	Lactation
 •	Infants w/ Down Syndrome
 |  | 
        |  | 
        
        | Term 
 
        | Atropine comes in what forms? |  | Definition 
 
        | PFS, vial, ampule and autoinjector |  | 
        |  | 
        
        | Term 
 
        | How does atropine come prepared? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of atropine for bradycardia? |  | Definition 
 
        | 0.5 to 1 mg, q @ 3-5 min, MTD 3 mg |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of atropine for poison? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the onset of atropine? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the duration of atropine? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Atropine admin side-effects: |  | Definition 
 
        | •	Drowsiness •	Confusion
 •	Blurred vision
 •	Tachycardia
 •	Heart palpitations
 •	Dry mouth
 •	Constipation
 •	Urinary hesitancy
 •	Pulmonary edema
 •	Flushing/decreased sweating
 |  | 
        |  | 
        
        | Term 
 
        | What are the interaction concerns of atropine? |  | Definition 
 
        | May alter the absorption of orally administered drugs by slowing the motility of the GI tract. |  | 
        |  | 
        
        | Term 
 
        | What is the trade name of diltiazem? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What class of drug does diltiazem belong to? |  | Definition 
 
        | Class IV Antiarrythmic (Ca++ Blocker) |  | 
        |  | 
        
        | Term 
 
        | What are the actions of diltiazem? |  | Definition 
 
        | •	Arterial Vasodilator •	Negative dromotrope
 |  | 
        |  | 
        
        | Term 
 
        | Indications for diltiazem admin: |  | Definition 
 
        | •	AFib and AFlut •	MAT
 •	PSVT (2nd line)
 |  | 
        |  | 
        
        | Term 
 
        | Contraindications for diltiazem admin: |  | Definition 
 
        | •	HypoTN •	Sick sinus syndrome
 •	WPW
 •	VTach
 •	AMI
 •	2nd and 3rd Degree HB
 |  | 
        |  | 
        
        | Term 
 
        | Diltiazem is available in what form? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | How does diltiazem come prepared? |  | Definition 
 
        | 25 mg/5 mL and 50 mg/10 mL |  | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of diltiazem? |  | Definition 
 
        | 10 mg over 2 min, q @ 10-15 min |  | 
        |  | 
        
        | Term 
 
        | What is the onset of diltiazem? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the duration of diltiazem? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Side-effects of diltiazem admin: |  | Definition 
 
        | •	1st and 2nd Degree HB •	Bradycardia
 •	Ventricular dysrhythmias
 •	HypoTN
 •	Syncope
 •	Flushing
 •	Chest pain
 |  | 
        |  | 
        
        | Term 
 
        | What are the interaction concerns of diltiazem? |  | Definition 
 
        | •	Potentiates Versed, ASA •	Don’t combine w/ B-blockers or Lasix
 |  | 
        |  | 
        
        | Term 
 
        | What are the special considerations of Tx a Pt with diltiazem? |  | Definition 
 
        | •	Shelf life of approx. 30 days (so rarely carried prehosp) •	In general, a Pt with Afib will rarely be Tx (preference is cardioversion or transport for Dr review)
 |  | 
        |  | 
        
        | Term 
 
        | What are the trade names of dopamine hydrochloride? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What class of drugs does dopamine belong to? |  | Definition 
 
        | Inotrope (adrenergic dopaminergic catecholamine sympathomimetic) |  | 
        |  | 
        
        | Term 
 
        | Where is the site of action for dopamine? |  | Definition 
 
        | Naturally occurring catecholamine that is the chem precursor of NE. |  | 
        |  | 
        
        | Term 
 
        | What are the indications of dopamine? |  | Definition 
 
        | •	Cardiogenic shock •	Cardiogenic shock with pulmonary edema (CHF)
 •	Hypovolemic shock/HypoTN (after fluid resuscitation)
 •	Neurogenic shock
 •	Septic shock
 •	Refractory symptomatic bradycardia
 •	HypoTN after ROSC (return of spontaneous circulation)
 |  | 
        |  | 
        
        | Term 
 
        | What are the contraindications of dopamine admin? |  | Definition 
 
        | •	Hypovolemic shock •	Pheocromocytoma
 •	Tachydysrhythmias
 •	Women on oxytocin
 •	VFib/VTach
 |  | 
        |  | 
        
        | Term 
 
        | What are the precautions of dopamine admin? |  | Definition 
 
        | •	Have two lines, one for dopamine, other for other drugs •	DO NOT MIX DOPAMINE AND SODIUM BICARB!!!
 |  | 
        |  | 
        
        | Term 
 
        | Dopamine is available in what forms? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | How does dopamine come prepared? |  | Definition 
 
        | 200, 400, or 800 mg in 5 mL |  | 
        |  | 
        
        | Term 
 
        | What are the dose specific actions of dopamine? |  | Definition 
 
        | Dose dependent actions of Dopamine •	1-2 mcg/kg/min—increases renal blood flow
 •	2-10 mcg/kg/min—inotropic and chronotropic effects as stimulate B1 receptors (below 5 mcg will still get renal effects)
 •	10-20 mcg/kg/min—vasoconstriction of renal and peripheral arteries/veins via stimulation of B1 and A receptors
 •	>20 mcg/kg/min—mimics NE’s pure alpha effects
 |  | 
        |  | 
        
        | Term 
 
        | What's the adult dosage of dopamine? |  | Definition 
 
        | •	2-20 mcg/kg/min; not to exceed 20 mcg/kg/min w/o med direction.  Generally start at 5-10 mcg/kg/min. |  | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the side-effects of dopamine admin? |  | Definition 
 
        | •	Dysrhythmias •	HTN
 •	HA
 •	NV
 •	Dizziness
 •	Ectopy
 •	Bradycardia
 •	Tremors
 •	Angina, AMI
 •	Pain
 •	Tachycardia incl. VTach/VFib
 |  | 
        |  | 
        
        | Term 
 
        | What are the signs of dopamine toxicity? |  | Definition 
 
        | •	Tachycardia •	Dysrhythmias
 |  | 
        |  | 
        
        | Term 
 
        | What are the interaction concerns of dopamine? |  | Definition 
 
        | TCAs, MAOIs, bretylium, precipitates alkaline solutions (sodium bicarb) |  | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | What drug class does epinephrine belong to? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | •	Alpha 1—constricts blood vessels, smooth muscles, stimulates glucose production, and decreases GI venous supply •	Beta 1—Heart, stimulates SA node and L ventricle
 •	Beta 2—Lungs, relaxes smooth muscle of the lungs, blood vessels, uterus and cerebellum
 |  | 
        |  | 
        
        | Term 
 
        | What are the actions of epi? |  | Definition 
 
        | •	Constricts blood vessels •	Increases HR
 •	Increases heart contractility
 •	Decreases GI blood supply
 •	Counteracts histamine
 •	Dilates bronchioles
 |  | 
        |  | 
        
        | Term 
 
        | What are the indications for epi admin? |  | Definition 
 
        | •	Anaphylaxis/Allergic rxn •	Bronchial asthma
 •	Cardiac arrest
 •	Pediatric symptomatic bradycardia
 •	Severe hypoTN w/ bradycardia when Atropine/pacing fail (secondary med)
 •	Croup
 |  | 
        |  | 
        
        | Term 
 
        | What are the contraindications of epi admin? |  | Definition 
 
        | •	None in cardiac arrest or life-threatening situations •	Lower dose or admin slowly in Pts w/ heart disease
 •	Hypovolemic shock
 |  | 
        |  | 
        
        | Term 
 
        | What are the precautions of epi admin? |  | Definition 
 
        | •	MAOI may potentiate effects •	May be deactivated by sodium bicarb (so flush line before admin Epi)
 •	Do not use PFS for Epi infusions
 •	Syncope in asthmatic children can occur
 •	Have EKG and IV in place
 |  | 
        |  | 
        
        | Term 
 
        | Epi is available in what forms? |  | Definition 
 
        | PFS, vials, and auto-injectors |  | 
        |  | 
        
        | Term 
 
        | How does epi come prepared? |  | Definition 
 
        | •Vials—1 mg/1 mL (1:1,000) or 1 mg/10 mL (1:10,000) •Auto-injector—0.3 mg/mL (1:2,000) for adult, 0.15 mg/mL for peds
 |  | 
        |  | 
        
        | Term 
 
        | What are the routes of epi admin? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the proper doses of epi? |  | Definition 
 
        | Severe Bradycardia/HypoTN (extremely rare except w/ peds) •	Adult—2-5 mcg/min infusion titrated to response
 
 Pulseless Arrest
 •	Adult—1 mg (1:10,000) IV/IO push diluted in 10 mL, rpt 3-5 min
 
 Anaphylactic Arrest
 •	Adult—(mild) 0.3-0.5 mg (1:1,000) IM/SQ, q 15 min; (severe) 0.3-0.5 mg (1:10,000) slow IV over 5 min
 
 Croup
 •	0.25-0.5 mL of a 2.25% solution
 |  | 
        |  | 
        
        | Term 
 
        | What is the onset of epi? |  | Definition 
 
        | SQ/IM 5-10 min IV/ETT 1-2 min
 |  | 
        |  | 
        
        | Term 
 
        | What is the duration of epi? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are special considerations relative to epi dosing and admin route? |  | Definition 
 
        | SQ/IM use 1:1,000 IV/ETT use 1:10,000
 |  | 
        |  | 
        
        | Term 
 
        | What is the trade name of lidocaine hydrochloride? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | Lidocaine belongs to what class of drugs? |  | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | Depresses the action potential of purkinje fibers. |  | 
        |  | 
        
        | Term 
 
        | What are the actions of lidocaine? |  | Definition 
 
        | •	Increases the ventricular threshold (increases refractory period of cells) •	Blocks fast Na+ channels
 •	Decreases Phase 4 depolarization
 |  | 
        |  | 
        
        | Term 
 
        | What are the indications for lidocaine admin? |  | Definition 
 
        | •	Stable monomorphic VTach w/ pulse •	Pulseless VTach/VFib
 •	Prophylactic for ICP pre-RSI
 •	PVCs (currently not recommended)
 |  | 
        |  | 
        
        | Term 
 
        | What are the contraindications of lidocaine admin? |  | Definition 
 
        | •	Advanced AV blocks •	IVR/Bradycardia
 •	Adam-Stokes Syndrome
 •	HypoTN
 •	WPW
 |  | 
        |  | 
        
        | Term 
 
        | What are the precautions of lidocaine admin? |  | Definition 
 
        | Cut maintenance dose in half if they are heptic impaired, in shock, or in heart failure. |  | 
        |  | 
        
        | Term 
 
        | How does lidocaine come prepared? |  | Definition 
 
        | •	2% (100 mg/5 mL), PFS •	20% (1 g/5 mL), pre-mixed solution for maintenance dose
 •	1 g/250 mL, maintenance mixture
 |  | 
        |  | 
        
        | Term 
 
        | What are the routes of lidocaine admin? |  | Definition 
 
        | •	IV, IO, IM, ETT (1 of 4, LEAN) •	Remember with ETT, dose is 2-2.5x normal dose (but still equates to single IV dose)
 |  | 
        |  | 
        
        | Term 
 
        | What are the four drugs that can be administered via ETT? |  | Definition 
 
        | Lidocaine, Epi, Atropine, Narcan |  | 
        |  | 
        
        | Term 
 
        | What are the adult doses of lidocaine? |  | Definition 
 
        | •	Cardiac Arrest—1 or 1.5 mg/kg (usually 1.5 mg), q 3-5 min, MTD 3 mg/kg (so typically admin’d 2x) •	Maintenance Dose—1 g/250 mL NS (4 mg/mL), @ 2-4 mg/min (rd up total Bolus dose to next whole number for maintenance dose)
 o	Only hang maintenance dose if rhythm converted
 •	Vent. Ectopy/Wide Complex Tachycardia—intial dose 1 or 1.5 mg/kg, with MTD 3 mg/kg, and rpt doses half initial dose
 |  | 
        |  | 
        
        | Term 
 
        | What is the onset of lidocaine? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the duration of lidocaine? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the side effects of lidocaine admin? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the signs of lidocaine toxicity? |  | Definition 
 
        | •	Seizure •	Tinnitus
 •	Fasciculation
 •	Slurred speech
 •	ALOC
 |  | 
        |  | 
        
        | Term 
 
        | What are the interaction concerns of lidocaine admin? |  | Definition 
 
        | Added cardiac depression when used concurrently with amiodarone, procainamide, and B-Blockers |  | 
        |  | 
        
        | Term 
 
        | What is the trade name of vasopressin? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What class of drugs does vasopressin belong too? |  | Definition 
 
        | Antidiuretic hormone (naturally occurring in the body...ADH) |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | •	Vasoconstrictor w/o inotropic or chronotropic effects and a smooth muscle stimulator in the GI tract |  | 
        |  | 
        
        | Term 
 
        | Vasopressin is indicated for the Tx of... |  | Definition 
 
        | Cardiac Arrest (and diabetes insipidus) |  | 
        |  | 
        
        | Term 
 
        | What are the contraindications of vasopressin admin? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the precautions of vasopressin? |  | Definition 
 
        | •	Migraine •	Epilepsy
 •	CHF
 •	CAD
 •	Asthma
 |  | 
        |  | 
        
        | Term 
 
        | Vasopressin is available in what form? |  | Definition 
 
        | Vial (5 units/mL or 20 units/mL) |  | 
        |  | 
        
        | Term 
 
        | Vasopressin is admin'd via what route? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What is the adult dosage of vasopressin? |  | Definition 
 
        | 40 units in one single dose |  | 
        |  | 
        
        | Term 
 
        | The onset of vasopressin is... |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What's the duration of vasopressin? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | What are the side-fx of vasopressin? |  | Definition 
 
        | Post resuscitation, may see: o	Ischemic chest pain
 o	ABD distress
 o	NV
 o	Bronchial constriction
 o	Tremors
 o	Sweating
 |  | 
        |  | 
        
        | Term 
 
        | What are the interaction concerns of vasopressin? |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | In what way can vasopressin be utilized during cardiac arrest? |  | Definition 
 
        | Can be used in place of 1st and 2nd dose of epi in cardiac arrest Tx (1 dose of vasopressin = 2 doses of epi). |  | 
        |  | 
        
        | Term 
 
        | What are the side effects of digoxin? |  | Definition 
 
        | •	HA •	Weakness
 •	Confusion
 •	Seizures
 •	HypoTN
 •	NV
 •	Skin rash
 •	High-degree AV blocks
 |  | 
        |  | 
        
        | Term 
 
        | What are the signs of dig-toxicity? |  | Definition 
 
        | •	Dysrhythmias (most commonly junctional tach) •	Visual disturbances (blurred, yellow or green vision)
 |  | 
        |  | 
        
        | Term 
 
        | What are the interaction concerns of digoxin? |  | Definition 
 
        | •	Amiodarone, vererpamil, and quindine may increase serum digoxin concentration by 50-70% •	Erythromycin and tetracycline may increase serum digoxin levels by reducing hepatic breakdown
 •	Diuretics may potentiate digoxin cardiotoxicity via loss of K+
 |  | 
        |  | 
        
        | Term 
 
        | You would use these medications to Tx ischemic chest pain. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | You would use these drugs for the Tx of shock. |  | Definition 
 
        | Epi (anaphylactic) and Dopamine (cardiogenic, hypovolemic W/ FLUID Tx, neurogenic, and septic) |  | 
        |  | 
        
        | Term 
 
        | You would use these drugs to Tx symptomatic bradycardia/hypoTN. |  | Definition 
 
        | Dopamine (after ROSC), atropine and epi. |  | 
        |  | 
        
        | Term 
 
        | These drugs are used in cardiac arrest. |  | Definition 
 
        | Epi, amiodarone, lidocaine and vasopressin. |  | 
        |  | 
        
        | Term 
 
        | These drugs are used to Tx Vtach and Vfib. |  | Definition 
 
        | Amiodarone and Lidocaine. |  | 
        |  | 
        
        | Term 
 
        | You would use this drug in suspected pesticide (organophosphate) poisoning. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | This drug is used to Tx SVTs and WCTs. |  | Definition 
 | 
        |  | 
        
        | Term 
 
        | This drug is used to Tx Afib/Aflut, MAT, and PSVTs. |  | Definition 
 | 
        |  |