| Term 
 
        | common symptoms of End-Stage |  | Definition 
 
        | fatigue, anorexia-cachexia, constipations, N/V, delirium, dyspnea, pain |  | 
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        | SSRIs, other antidepressants |  | 
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        | antihistamines, B blockers, statins, benzos |  | 
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        | benzos, anti-hypertensives |  | 
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        | a separate medical benefit |  | 
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        | patient must have less than 6 months to live |  | 
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        | Term 
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        | pay little/ nothing for med (which are directly provided), med orders based on protocol, allows rapid change in pain meds if needed |  | 
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        | hospice covers comfort care |  | Definition 
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        | Term 
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        | patients may have terminal illness, focused on comfort care, BUT may have condition with which they could live for years |  | 
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        | severe COPD, painful conditions like compression fractures or rheumatoid arthritis |  | Definition 
 
        | conditions where patients might live for years, but patient might need end of life care |  | 
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        | palliative care is not necessarily terminal |  | Definition 
 
        | could still have curative focus even while providing comfort |  | 
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        | possible symptom management suggestions |  | Definition 
 
        | appropriate meds, dosing and easiest route for patient |  | 
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        | Term 
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        | may be related to difficulty swallowing at end of life, potentially from severe nausea |  | 
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        | cannot be used if patient is opioid NAIVE |  | 
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        | appropriate initiation of fentanyl patch |  | Definition 
 
        | patient must be taking at least 60 mg of morphine per day or equivalent for 25 mcg/hr patch |  | 
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        | fentanyl patch can still cause nausea |  | Definition 
 
        | because nausea caused by opioid is a systemic effect |  | 
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        | fentanyl patch may be ineffective in cachectic patients |  | Definition 
 
        | because in these patients there is LESS fat leading to less absorption |  | 
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        | Term 
 | Definition 
 
        | potential issue in cancer patients |  | 
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        | concentrated opioid solutions |  | Definition 
 
        | small volume, easier to mix with food |  | 
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        | concentrated opioid solutions |  | Definition 
 
        | can be placed under tongue and allow to be absorbed if patient is not eating at all |  | 
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        | concerns when using concentrated opioid solutions |  | Definition 
 
        | MUST be careful with dosing, use dropper that comes with bottle, educate caregiver! |  | 
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        | as needed/ short term basis due to dosing limitations and not easy route |  | 
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        | at home with ACUTE need may "make" suppositories |  | Definition 
 
        | butter/ vaseline can be used with smaller oral tablets of oxycontin/ MS contin (ONLY do this other options are not available) |  | 
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        | allow the most flexible dosing (easy adjustment) |  | 
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        | SC route preferred over IV rout |  | Definition 
 
        | when at home because there is lower risk of infection |  | 
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        | volume limitations when doses are increased |  | 
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        | epidural or intrathecal route |  | Definition 
 
        | useful if other methods not effective, more complicated procedure |  | 
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        | allow drug delivery to most localized area (trathecal/ epidural) |  | Definition 
 
        | may provide better pain relief, reduces CNS side effects |  | 
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        | Term 
 | Definition 
 
        | patient can take more medication |  | 
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        | physical symptoms if the med is not taken |  | 
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        | taking drug becomes more important that the original benefit from it |  | 
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        | an addict takes a med to get away from life |  | Definition 
 
        | someone seeking pain relief takes med to get on with life |  | 
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        | does not facilitate the healing of wounds or prevent pressure ulcers in end of life |  | 
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        | increased risk of aspiration, diarrhea and other complications |  | Definition 
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        | contribute to wasting syndromes |  | 
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        | weight loss is common in end of life |  | Definition 
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        | less appealing, body is slowing down |  | 
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        | altered phisiology and body chemistry at end of life |  | Definition 
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        | eliminate dietary restrictions |  | Definition 
 
        | and provide favorite foods, smaller and more frequent |  | 
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        | some potentially inappropriate meds for geriatrics |  | Definition 
 
        | may become appropriate (anti-nausea); more worried about comfort than side effects |  | 
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        | Term 
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        | sometimes used for severe nausea because it is a very strong dopamine blocker |  | 
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        | may be the cause of nausea especially as pain meds are increased |  | 
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        | promethazine, prochlorperazine |  | Definition 
 
        | may make constipation worse especially if it is the cause of nausea |  | 
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        | Term 
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        | may not need to treat hallucinations or behaviors; only an issue if at risk of harming self/ others |  | 
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        | no need to start dementia meds |  | 
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        | unnecessary offending medications |  | 
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        | NMDA receptor antagonist properties, useful for allodynia |  | 
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        | pain due to a stimulus that doesn't normally cause pain |  | 
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        | appropriate for patients with allodynia |  | Definition 
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        | must be dosed cautiously, not first line but might be useful for some cases |  | 
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        | may also be helpful for allodynia |  | 
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        | used in anethesia most commonly, also blocks NMDA; might be used for advanced allodynia cases |  | 
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        | inflammation can be cause of pain in bone metastases |  | Definition 
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        | dexamethasone, prednisone |  | Definition 
 
        | useful for pain caused by inflammation (bone metastases) |  | 
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        | might be useful for bone pain (high dose) |  | 
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        | less effective than glucocorticoids, consider possible adverse reactions |  | 
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        | subjective symptom of not being able to breath |  | 
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        | Term 
 | Definition 
 
        | not necessarily associated with decreased O2 in bloodstream, may occur with progressive cancer and other conditions |  | 
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        | treatments of "air hunger" |  | Definition 
 
        | oxygen, opioids, benzos are most common |  | 
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        | in terminal dyspnea, respiratory center |  | Definition 
 
        | is like a thermostat that keeps heat pumping out when temp is already too hot |  | 
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        | may calm respiratory center down |  | 
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        | with hyperactivity of respiratory center you have |  | Definition 
 
        | DECREASED risk of respiratory suppression, as long as doses are appropriate |  | 
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        | easiest for opioids/ benzos for respiratory hyperactivity |  | 
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        | not always effective in trials but often works in practice |  | 
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        | benefits of nebulized opioids |  | Definition 
 
        | may be related to Mu receptors in lungs |  | 
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        | Term 
 | Definition 
 
        | may be caused by nebulized opioid |  | 
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        | best option for nebulized opioid |  | Definition 
 
        | preservative-free intravenous opioid often used to prevent sensitivity |  | 
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 | Definition 
 
        | lroazepam oral, can be sublingual (can give IV via neb) |  | 
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        | more predictable half-life |  | 
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        | opioids and benzos can be used together |  | Definition 
 
        | if added benefit seems to be helpful |  | 
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        | suction for oral secretions |  | Definition 
 
        | extremely uncomfortable and rarely necessary at end of life |  | 
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        | if oral secretions are uncomfortable for the patient |  | Definition 
 
        | anticholinergics can help |  | 
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 | Definition 
 
        | often preferred because a low dose can be used for unwanted oral secretions |  | 
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        | stimulant that might be helpful for drowsiness/fatigue from opioids or other treatments |  | 
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