Term
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Definition
| Compounds present in opium. |
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Term
| What are the 3 endogenous opioid peptides? |
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Definition
| Dinorphins, Endorphins, Enkephalins |
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Term
| What purposes doe endogenous peptides serve? |
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Definition
| Neuromodulators, neurohormones, neurotransmitters |
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Term
| What is the response to stimulation of MU opioid receptors: |
|
Definition
| Analgesia, respiratory depression, euphoria and sedation |
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Term
| What is the response to stimulation of Kappa opioid receptors: |
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Definition
| Analgesia, sedation--possible psychomimetic effects (paranoid dilusions) |
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Term
| What is the response to stimulation of DELTA opioid receptors: |
|
Definition
| Not usually involved in analgesics |
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Term
| What is the MOA of morphine? |
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Definition
| Binds to opiate receptors in the CNS causing inhibition of ascending pain pathways altering perception and response to pain produces generalized CNS depression |
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Term
| what are the three classes of opioid analgesics? |
|
Definition
| Pure Agonists (Mu and Kappa activators), Agonist-Antagonist, Pure Antagonist (no analgesia, reverses respiratory and CNS depression) |
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Term
| Where does morphine come from? |
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Definition
| The seeds of the poppy plant. |
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Term
|
Definition
| Decreases ESP constant dull pain, decreases cough, decreases anxiety |
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Term
| What are the primary side effects of opioid analgesics |
|
Definition
| Respiratory depression, urinary retention, constipation, drowsiness, euphoria |
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Term
| What are some ways to decrease the side effects of opioid analgesics: |
|
Definition
| Monitor RR before and after if 12 breaths/min or less w/h and notify!!!, educate pts RE risk of respiratory depression and instruct them to notify prescriber if occurs. |
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