Term
| What is the first approach to the Influenza viurs? |
|
Definition
|
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Term
| What is the MOA for Tamilfu and Relenza? |
|
Definition
| They are neuraminidase inhibitors that affrect the release of viral particles |
|
|
Term
| What should treatmen of the flu be initiated? |
|
Definition
| Within 48 hrs of the onset of symptoms |
|
|
Term
| What affect does tamiflu have on the duration adn severity of the flu? |
|
Definition
| Reduce severity and duration by 1-1.5 days and reduce the incidence of lower resp tract complications |
|
|
Term
Which types of the infleunza virus is each affective against?
1) Tamilfu
2)Relenza
3)Symmetrel
4) Flumadine |
|
Definition
1) Tamilfu- A&B
2)Relenza-A&B
3)Symmetrel-A only
4) Flumadine-A only |
|
|
Term
T/F
Oseltamivir needs to be converted into an actice form |
|
Definition
TRUE
it is a prodrug requiring ester hydrolysis into its actice form |
|
|
Term
What is the minumum age for people taking Tamilfu?
What are the symptom requirements? |
|
Definition
| 1 year and symptomatic for less than 2 days |
|
|
Term
| Can Tamilfu be used for prophylaxis? |
|
Definition
|
|
Term
| What are common ADE of tamiflu? |
|
Definition
| nausea, vomiting, and diarrhea |
|
|
Term
| What pregnancy category is tamiflu? |
|
Definition
|
|
Term
| What concentration is Tamiflu powder for suspension? |
|
Definition
|
|
Term
| What concentration is Tamiflu is using the capsule for suspension? |
|
Definition
|
|
Term
| What is the recommended treatment dose for Tamiflu in adults? |
|
Definition
|
|
Term
What is the recommended prophylaxis dose for Tamiflu in adults?
(Outbreak & Close Contact) |
|
Definition
Outbreak- 75mg QD indefinitely
Contact- 75mg QD x 10 days |
|
|
Term
| What is the minimum age for Zanamivir (Relenza)? |
|
Definition
|
|
Term
| How is Relenza administered? |
|
Definition
|
|
Term
| Who can use Relenza for prophylaxis? |
|
Definition
| adults and children 5 years and older |
|
|
Term
| IN what patients has Zanamivir not been proven effective for? |
|
Definition
People with underlying airway diseases
prophylaxis in a nursing home |
|
|
Term
| What are the contraindications for Zanamivir? |
|
Definition
| People with a history of allergic reaction to any ingrediant in the formula and lactose |
|
|
Term
| How is Zanamivir supplied? |
|
Definition
| on a Rotadisk with 5mg blisters of powder for oral inhalation |
|
|
Term
| What are some common ADE of Zanamivir? |
|
Definition
| dizziness, sinusitis and fever/chills |
|
|
Term
| What is the dosage for Zanamivir? |
|
Definition
|
|
Term
| What is the dosage for prophylaxis in the hosptial and community setting? |
|
Definition
Hospital 10mg QD x 10 days
Community 10mg QD x 28 days |
|
|
Term
| What can be used for treatment of the flu in acutely ill patients? |
|
Definition
Peramivir
Not yet fully approved |
|
|
Term
| What was the first drug found to work against type A influenza only? |
|
Definition
|
|
Term
| What are the ADE of Amantadine and Rimantadine? |
|
Definition
CNS effects nervousness, anxiety, lethargy
Rimantadine is less likely to have ADE
may cause anticholinergic ADE |
|
|
Term
| What steps should be taken with amantadine and patients with renal dysfunction? |
|
Definition
| Dosage should be monitored b/c the drug is primarily excreted in the urine |
|
|
Term
| Can Amantadine and Rimantadine be used during pregnancy? |
|
Definition
| No it has been shown to cause teratogenic effects in animals |
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