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        | osteroarthritis definition |  | Definition 
 
        | wearing down of joints, especially cartilage; does not involve the immune system so you don't need to give something for inflammation |  | 
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 | Definition 
 
        | inhibits substance P involved in pain signaling, does not block pathway, might take few weeks to see improvement |  | 
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        | Term 
 | Definition 
 
        | recommended over oral NSAIDs with reduced risk for side effects, epensive |  | 
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        | Term 
 
        | lidoderm patch; lidocane topical |  | Definition 
 
        | might be useful for specific pain (ie. back pain); expensive and might not be covered |  | 
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        | Term 
 | Definition 
 
        | 500mg X 6 tabs/day = 3000mg limit |  | 
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        | 325 X 10 tabs/day = 3250mg limit |  | 
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        | 650mg X 6 tabs/day = 3900mg limit |  | 
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 | Definition 
 
        | inhibits Cox1 (housekeeping) and Cox2 (inflammation) |  | 
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 | Definition 
 
        | housekeeping; involved in mucus layer production in stomach, ulceration occurs from systemic effect |  | 
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        | Term 
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        | inhibition of prostaglandins periferally; decreasing inflammation |  | 
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        | Salsalate, choline-magnesium salicylates |  | Definition 
 
        | non-acetylated salicylates; weaker than some NSAIDs but better SE profile |  | 
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        | Term 
 | Definition 
 
        | used to help re-build cartilage; takes time (4-6wks) |  | 
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        | Term 
 | Definition 
 
        | similar to heparin, may increase risk of bleeding |  | 
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        | Term 
 | Definition 
 
        | may increase glucose in blood, debated |  | 
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        | Term 
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        | for severe cases and can acquire tolerance, causes CONSTIPATION |  | 
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        | used to lubricate the joint, used in knee as injection (medical device rather than drug) |  | 
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        | Term 
 | Definition 
 
        | may be useful for acute pain, helpful for patients with local inflammation and joint effusion; no more than every three months |  | 
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