Term
| what are the categories of non neoplastic bone diseases |
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Definition
inherited diseases (from chapter 6)
benign and malignant neoplasms (chapter 7)
central and peripheral giant cell granulomas (chapter 2)
aneurysmal bone cyst (chapter 5) |
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Term
| three forms of cemento-osseous dysplasia |
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Definition
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Term
| dyspasia of cemento osseous and fibrous refers to |
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Definition
| disordered production of cementum and bone. |
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Term
| benign fibro-0sseous lesions of the jaws examples |
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Definition
fibrous dysplasia( monostotic, polystotic/jaffe and albright, and craniofacial type.
periapical cemento-ossifying fibroma
cemento ossifying fibroma
cementifiying fibroma
cementoblastoma
focal cemento-osseous dysplasia
florid cemento osseous dysplasia
peripheral ossifying fibroma |
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Term
| benign fibro osseous lesion definition |
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Definition
benign lesion of bone characterized microscopically by cellular fibrous connective tissue admixed with irregularly shaped bone trabeculae or cementoid material.
vascularized, cellular fibrous connective tissue interspersed |
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Term
disease characterized by replacement of bone with abnormal fibrous connective tissue interspersed with varying amounts of calcification.
the cause of this disease is unknown but may be attributed to abnoramal mesenchymal cell function.
this appears like ground glass a diffuse radiopacity. can be unilocular or multilocular or a mix.
there are 3 types: monostotic, polystotic, or craniofacial |
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Definition
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Term
| three types of fibrous dysplasia |
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Definition
monostotic (one bone)
polystotic (more than 1 bone)
craniofacial (happens in craniofacial bones) |
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Term
this is the most common form of fibrous displasia
it affects mandible and maxilla, ribs, femur, tibea
Max usually more affected than mandible.
appears as painless swelling of bone or bulging of buccal plate.
expanded lesion can cause malocclusion, tipping or displacement of adjacent teeth.
teeth are rarely mobile |
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Definition
| monostotic fibrous displasia |
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Term
this type of fibrous displasia usually occurs more often with children and more often in females it is characterized by involvement of more than 1 bone.
it affects skull, face, clavicles, long bones are most effected.
cafe au lait spots present |
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Definition
| polystotic fibrous displasia |
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Term
| what are some forms are polystotic fibrous dysplasia |
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Definition
craniofacial
jaffe-lichtenstein
albright syndrome |
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Term
| this form of polystotic dysplasia involves maxilla and extends into the sinuses and adjacent to zygoma, sphenoid and occipital bones. |
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Definition
| craniofacial polystotic fibrous dysplasia |
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Term
| this form of polystotic fibrous displasia involves multiple long bones and cafe au lait macules on skin. |
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Definition
| jaffe-lichtenstein polystotic dysplasia |
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Term
this is the most severe type of polystotic fibrous dysplasia
involves endocrine abnormalities
precocious puberty in females
stunted/deformed skeletal growth of both males and females due to premature closing of epiphyseal plate
other complications that may happen are diabetes and hyperthyroidism.
also has cafe au lait macules on skin |
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Definition
| albright syndrome (a polystotic fibrous dysplasia) |
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Term
| clinical and radiographic appearance of fibrous dysplasia |
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Definition
ground glass can be multilocular, unilocular or both radiographically.
painless, progressive, unilateral enlargement of bone clinically. |
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Term
| periapical cemento osseous dysplasia/cementoma |
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Definition
common in african american women
common in anterior of mandible of pts over 30 yrs of age
not a neoplasm
a common disease with unknown cause that affects periapical bone
lesion composed of fibrous tissue and calcifications resembling bone cementum or both. |
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Term
the radiographic image of this dysplasia is of a middle aged african american woman.
she has well circumscribed early lesions and are radiolucent to start, as they calcify they become more radiopaque.
the teeth are vital
what dysplasia am i |
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Definition
periapical cemento-osseous dysplasia/ aka cementoma
a side note on histology: early lesions have more fibrous connective tissue, older lesions contain more calfications |
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Term
| when do cementifying and ossifying fibromas usually occur, specifically what life decades? |
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Definition
| third and fourth decade of life |
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Term
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Definition
| ossifying fibromas have calcifications that look more like trabeculae. |
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Term
| cemento-ossifying fibromas |
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Definition
| cemento ossifying fibromas are calcifications of cementum, bone and trabeculae. |
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Term
| how would you treat cementifying and ossifying fibromas? |
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Definition
| surgical excision is needed for cementifying and ossifying fibromas. |
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Term
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Definition
producing lesion that is fused to the root of the tooth.
radiographically there is a mass in continuity with the root or apex of tooth. a radiolucent halo surrounds it.
they often occur in young adults
commonly seen with mandibular molar or premolar.
pain is a symptom
treatement includes ucleation of tumor and removal of involved teeth. they do not re occur. |
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Term
| focal cemento osseous dysplasia |
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Definition
usually occurs in females ages 30-50
is more common in african american women
occurs in posterior of mandible as an isolated well delineated radiolucent to radiopaque lesion 1.5cm in size
composed of many gritty pieces of fibrous connective tissue intertwined with bone trabeculae and cementum like material
this can progress to florid cemento osseous dysplasia |
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Term
| florid cemento osseous dysplasia |
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Definition
characterized by disordered cementum and bone development.
involves multiple quadrants in maxilla and mandible
occurs usually in african american women over 40
radiographically large radiopaque, dense, sclerotic masses of bone/cementum. it differs from periapical cemento-osseous dysplasia because it may involve several quads in maxilla/mandible. |
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Term
| paget's disease of bone (osteitis deformans) |
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Definition
a chronic metabolic bone disease (leoniasis ossea)
characterized by resorption, osteoblastic repair and remineralization of bone involved.
cause is unknown but suspected to be viral
it is slow progressing
serum alkaline phosphatase is elevated!!!
common in men over 50
affects pelvis spinal chord
enlarged bone and spacing between teeth can occur
headache, dizziness, deafness can happen due to enlarged bone inpinging on cranial nerves. |
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Term
radiographically this disease shows up like cotton-wool appearance it is patchy radiolucent and radiopaque.
bone also has a mosaic bone appearance: involved bone shows prominent reversal lines that result from resorption and deposition of bone. |
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Definition
| paget disease/osteitis deformants/leoniasis ossea |
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Term
| what are some problems that can go along with pagets disease radiographically besides the cotton wool appearance? |
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Definition
| hypercementosis, loss of lamina dura, obliteration of PDL |
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Term
| in pagets disease why would overlying skin of affected bone feel warm? |
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Definition
| becasue the connective tissue between trabeculae is so well vascularized. |
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Term
| what are complications associated with pagets disease? |
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Definition
| fracture, malignant tumor, heart disease |
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Term
| what causes osteomalacia? |
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Definition
a calcium deficiency over a long time
rickets occurs in children with vit. D deficiency
in adults caused by malabsorption syndrome, drugs, liver/kidney disease, chronic antacid use or tumors |
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Term
| clinically what do you see with osteomalacia |
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Definition
delayed tooth eruption
periodontal disease
pathologic fractures |
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Term
| central giant cell granuloma |
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Definition
a non-neoplastic leasion of unclear origin
composed of well vascularized connective tissue containing multinucleated giant cells, red blood cells and chronic inflammatory cells.
occurs in peripheral (gingiva or alveolar mucosa) and central(within bone)
affects anterior of maxilla and mandible
it affects children and young adults/ females most common
it is similar to a lesion that occurs in pts with hyperparathyroidism |
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Term
radiolucency in bone
borders are sclerotic or ill defined
unilocular or multilocular
divergence of roots of teeth adjacent to lesion
this is a radiographic description of what condition? |
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Definition
| Central Giant cell granuloma |
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Term
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Definition
| a pseudocyst that consists of blood filled spaces surrounded by giant multinucleated cells and fibrous connective tissue. no epithelial lining. |
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Term
| osteopetrosis/ albers-schonberg disease |
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Definition
rare congenital disorder where bones are overly dense.
due to imbalance between formation of bone and bone breakdown.
bone appears dense on x ray and cannot resist average stressors and breaks easily.
diagnosed with bone density, CAT scans or MRI skeletal xray |
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Term
| a 48 yr old black woman has multiple asymptomatic radiopaque masses in the mandible and maxilla. no expansion on bone is noted what is the most likely diagnosis? |
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Definition
| florid cemento osseous dysplasia because it has affected both maxillary and mandibular. |
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Term
all of the following are examples of benign fibro-osseous lesions except:
a. fibrous dysplasia
b. periapical cemento-osseous dysplasia
c. central ossifying fibroma
d. osteoma |
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Definition
| Osteoma is not a benign fibro-osseous lesion |
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Term
| what is the disease that is characterized by precocious puberty in females? |
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Definition
| albright-Mccune type fibrous dyspasia |
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Term
| periapical cemento osseous dysplasia is located in which part of the mouth? |
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Definition
| periapical cemento osseous dysplasia is located in the anterior mandible |
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Term
| what is another name for periapical cemento osseous dysplasia? |
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Definition
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Term
| what condition of the bone often has cafe au lait spots? |
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Definition
| polyostotic fibrous dysplasia types=cafe au lait spots |
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Term
| what is the name of the type of fibrous dysplasia that involves the maxilla and adjacent bones |
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Definition
| craniofacial involves maxilla and adjacent bones |
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Term
which of the following is not a feature of Paget disease?
A. deposition of amorphous material
B. resorption and osteoblastic repair
C. chronic metabolic bone disease
D. hypercementosis |
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Definition
| Deposition of amorphous material is not a feature of Paget's disease |
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Term
| The most characteristic radiographic appearance of fibrous dysplasia is described as? |
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Definition
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Term
all of the following are histologic features seen in Paget disease except:
A. osteoblasts and osteoclasts
B. bone with prominent irregular dark lines
C. well-vascularized fibrous connective tissue
D. hyperchromatic nuclei and atypical mitotic figures. |
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Definition
| hyperchromatic nuclei and atypical mitotic figures |
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Term
which of the following does not have a characteristic radiographic appearance.
A. Paget disease
B. Osteomalacia
C. Florid cemento osseous dyspasia
D. periapical cemento osseous dysplasia |
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Definition
| Osteomalacia does not have a characteristic radiographic appearance. |
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Term
in patients with fibrous dysplasia, which of the following is the only recommended treatment of modality.
A. Surgery
B. Radiation therapy
C. chemotherapy
D. sclerosing agent |
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Definition
| Surgery for fibrous dysplasia |
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Term
| what is elevated in Paget disease and can help diagnose it in a lab test? |
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Definition
| serum alkaline phosphotase |
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Term
| osteomalacia is caused by what vitamin deficiency? |
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Definition
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Term
| osteomalacia in children is called? |
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Definition
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Term
| in what fibrous dyplasia may there be an increased risk of osteosarcoma? |
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Definition
| Paget disease can lead to tumors and osteosarcoma |
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Term
which of the following is not true of the aneurysmal bone cyst?
A. radiographic honey comb appearance
B. it is a true cyst
c. associated with other primary bone lesions
D. usually treated with curettage and enucleation |
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Definition
B. it is a true cyst
this is false because aneurysmal bone cyst is a psuedocyst. |
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Term
| leontiasis ossea and osteitis deformans are other names for what disease |
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Definition
| these are other names for paget disease |
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Term
the central giant cell granuloma which one is true?
A. may occur on tongue
B. may present as a multilocular radiolucency
C. occurs in children under 6
D. is histologically the same as periapical granuloma |
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Definition
| central giant cell granuloma presents as multilocular radiolucency |
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Term
who does florid cemento osseous dysplasia usually effect?
A. hispanic men over 60
B. white women in 30's
C. black men under 30
D. black women over 40 |
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Definition
| florid cemento osseous dysplasia usually effects black women over 40 |
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Term
which is not a characteristic of Paget disease?
A. expansion of maxilla
B. occurs in young children
C. may have a cotton wool appearance
D. elevated serum alkaline phosphotase |
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Definition
| Pagets disease does not occur in young children |
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Term
brown tumors are associated with which
A. aneurysmal bone cyst
B. Fibrous dysplasia
C. osteomalacia
D. hyperparathyroidism |
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Definition
| brown tumors=hyperparathyroidism |
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Term
| pain is a common feature in which fibro ossous dysplasias |
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Definition
| pain in paget, polystotic, florid cemento osseous dyspasia |
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Term
pain is experienced with central giant cell granuloma?
T/F |
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Definition
| F. pain is not a common symptom of central giant cell granuloma |
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Term
Albright syndrome involves all but one of these:
A. prococious puberty in females
B. endocrine abnormalities
C. stunting or deformity of skeletal growth
D. characteristic loss of teeth |
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Definition
| characteristic loss of teeth is not associated with albright syndrome |
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Term
diabetes can be associated with which disease
a. albrights
b. pagets
c. periapical cemento osseous dysplasia
d. osteomalacia |
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Definition
| diabetes can be associated with albrights disease |
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