Term
| T/F Verruca vulgaris is the most common benign epithelial lesion? |
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Definition
| F...it's squamous papilloma |
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Term
| What does this describe? Small (up to 0.5 cm) exophytic, sessil or pedunculated papule? |
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Definition
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Term
| T/F Squamous papilloma can be located on any location in the oral cavity? |
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Definition
| T...prefers soft tissue, especially the tongue, lip, soft palate, and mostly the gingiva |
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Term
| What differentiates verruca vulgaris from squamous papilloma? |
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Definition
| verruca vulgaris is multiple, mostly on anterior part of oral cavity, and occurs often with young people with warts on their fingers. While squamous papilloma is in a single location. |
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Term
| T/F The etiology of squamous papilloma is HPV 6 and 11 |
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Definition
| F...it is only suspected, although it does appear in 50% of those with papilloma |
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Term
| Describe a squamous papilloma |
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Definition
| White (keratinized) or pink (lots of blood supply), pedunculated or sessile (exophytic) surface projections (papule or nodule) that usually doesn't grow larger than 0.5 cm. |
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Term
| T/F Squamous papilloma has the potential to become malignant? |
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Definition
| F...never! It is a slow growing, nonneoplastic papule with a central core of CT that is continous |
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Term
| What is the etiology of verruca vulgaris? |
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Definition
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Term
| What does a verruca vulgaris look like microscopically? |
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Definition
| Virus infected epithelial cells with clusters of koilocytes (pyknotic, raisin-like nucleus with a clear cytoplasm) which show up only in young lesions |
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Term
| What is the etiology of condyloma accuminatum? |
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Definition
| HPV 2,6,11 (better prognosis) or HPV 16, 18 (has oncogenic potential) |
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Term
| How do you differentiate condyloma accuminatum from verruca vulgaris? |
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Definition
| they both have koilocytes histologically and are multiple, but condyloma is fast-growing with coalescing papillomas that usually are a lot larger than the other epithelial lesions |
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Term
| T/F Up to 30% of squamous cancers in the oral cavity are caused by HPV? |
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Definition
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Term
| T/F You surgically excise all of the following as treatment? squamous papilloma, verruca vulgaris, condyloma accuminatum, heck's dx, keratoacanthoma, seborrheic keratosis? |
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Definition
| F...Heck's dx resolves on its own |
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Term
| T/F Heck's dx is a single papilloma that is acanthotic, sessile, soft papule caused by HPV 13. |
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Definition
| F....all is true except it is multiple (not single) |
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Term
| What was described in 1934 as "self-healing squamous cell carcinoma" and why was it called this? |
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Definition
| Keratoacanthoma because the fleshy nodule falls off |
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Term
| What has multiple small facial hair follicle tumors as well as multiple papules on gingiva, tongue and buccal mucosa? |
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Definition
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Term
| What benign epithelial lesion develops from hair follicles but does NOT occur in the mouth? |
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Definition
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Term
| What are 2 big differences between Keratoacanthoma and SCC (not on an individual but statistically)? |
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Definition
| keratoacanthoma's growth rate is much faster and forms equally on either lip...SCC only on the lower lip. |
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Term
| What are the 4 phases of a keratoacanthoma? |
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Definition
| 1.) Growth phase: 2-8 weeks 2.) Stationary phase: 2-8 weeks 3.)Involutional Phase (gets smaller): 2-8 weeks 4.) Healing/falls off 6 weeks to 6 months (leaving a scar) |
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Term
| What is different about the treatment of a keratoacanthoma? |
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Definition
| the excision must be complete and one biopsies the entire thing |
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Term
| What is multiple keratoacanthoma a sign of? |
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Definition
| undiagnosed internal malignancy |
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Term
| What benign epithelial lesion does this describe: soft, sessile, friable growth, that appears pink, white or brown but never becomes malignant? |
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Definition
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Term
| With what type of epithelial lesion can Leser Trelat occur and what is it? And what should you look for if it occurs? |
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Definition
| With seborrheic keratosis....it is when there are multiple lesions that suddely occur. You should look for internal malignancy (usually GI) |
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Term
| What do melanocytes come from embryologically? |
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Definition
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Term
| What is the difference between epidermal melanocytes and dermal melanocytes? |
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Definition
| epidermal: round, clear cells that do NOT store pigment dermal: produce & store melanin and are spindly elongated cells |
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Term
| What is a macrophage that ingests melanin called? |
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Definition
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Term
| What does this describe? yellow to brown macule that develop on exposed parts of skin and has increased melanin in basal layer but no increase in melanocytes? |
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Definition
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Term
| Describe a labial-vermillion melanocyte macule |
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Definition
| less than 7mm, symmetrical, no growth, histologically like freckle except always pigmented and doesn't respond to the sun |
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Term
| What is the difference between an oral melanocytic macule and malignant melanoma? |
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Definition
| smaller and symmetrical (even though they both start out the same way) |
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Term
| Where does the oral melanocytic macule most often occur? |
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Definition
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Term
| What is the scientific name for the "liver spot" and describe it |
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Definition
| Actinic lentigo: appears only on the skin(hands and shoulders of elderly) where there is an increase in a linear fashion of a melanocyte (histologically) |
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Term
| T/F A nevi is common in the mouth but uncommon on skin? |
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Definition
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Term
| What is it called when there are clusters of 5 or more melanocytes? |
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Definition
| Theque...occurs in a nevi |
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Term
| What is the histological difference between an oral melanocytic macule and a nevi? |
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Definition
| A nevi has an increase in melanocytes(while an oral melanocytic macule only has an increase in pigment, not melanocytes) |
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Term
| What is the difference between a fleshy colored nevus and papilloma? |
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Definition
| fleshy colored nevus is smooth, symmetrical and has been there a long time |
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Term
| Which type of theque form only at the zone of epidermis? |
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Definition
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Term
| which type of theque is in epidermis and CT? |
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Definition
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Term
| Which theque is only in CT? |
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Definition
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Term
| What is the tyndall effect on a blue nevus? |
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Definition
| the bluish tint due to light reflection |
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Term
| T/F You see theques in all type of nevi? |
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Definition
| F....there aren't any in blue nevi |
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Term
| What 2 lesions are due to child abuse or mimic child abuse? |
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Definition
| venereal condylomas in children ARE child abuse and mongolian spots MIMIC child abuse |
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Term
| T/F Racial pigmentation and heavy metal poisoning show up on attached gingiva? |
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Definition
| F...heavy metal poisoning shows up on free gingiva |
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Term
| Which Cafe au lait spots syndrome shows a jagged outline? |
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Definition
| Albright's sx....Neurofromatosis shows a smooth outline |
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Term
| What does this describe: perioral pigmentation around lips and on fingers; polyps through out GI tract? |
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Definition
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Term
| If a pt is craving salt, weak, has low BP and has multiple pigmented lesions on lips, intraorally, skin and nails, what do they most likely have? |
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Definition
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Term
| Name some of the drugs that can cause melanocytic macules |
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Definition
| minocycline, plaquenil, BCP, anti-malarials (chloroquine), phenolphthalein (in laxatives), AIDS meds, tranquilizers (chlorpromazine) |
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Term
| What is post-inflammartoey scarring often due to? |
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Definition
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Term
| What respiratory disturbance produces lots of ACTH? |
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Definition
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Term
| What are the non-melanocytic causes of pigmented lesions? |
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Definition
| Heavy metal poisoning, amalgam tattoo, blood filled lesions. |
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Term
| What epithelial lesions occur only in the skin? |
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Definition
| seborrheic keratosis and keratoacanthoma |
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Term
| What melanotic lesions occurs only in the skin? |
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Definition
| ephelis, lentigo, cafe au lait spots |
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Term
| What does Exophytic mean? |
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Definition
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Term
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Definition
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Term
| What does Pedunculated means? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| What is pseudoepitheliomatous hyperplasia? |
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Definition
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