Unilocular radiolucencies:

Pericoronal location

More likely:

• Hyperplastic dental follicle
• Dentigerous cyst

Likely:

• Eruption cyst
• Odontogenic keratocyst

Less Likely:

• Orthokeratinized odontogenic cyst
• Ameloblastoma
• Ameloblastic fibroma
• Adenomatoid odontogenic tumor
• Calcifying odontogenic cyst
• Carcinoma arising in dentigerous cyst
• Intraosseous mucoepidermoid carcinoma

Unilocular radiolucencies:

Periapical location

More likely:

• Periapical granuloma
• Periapical cyst

Likely:

• Periapical cemento-osseous dysplasia (early)

Less Likely:

• Periapical scar
• Dentin dysplasia type I

Unilocular radiolucencies:

Other locations

More Likely:

• Developing tooth bud

Likely:

• Lateral radicular cyst
• Nasopalatine duct cyst
• Lateral periodontal cyst
• Residual (periapical) cyst
• OKC
• Central giant cell granuloma
• Stafne bone defect

Less Likely:

• Cemento-osseous dysplasia
• Central ossifying fibroma
• Ameloblastoma
• Langerhans cell histiocytosis

More Likely:

• OKC
• Ameloblastoma

Likely:

• Central giant cell granuloma

Less Likely:

• Ameloblastic fibroma
• Odontogenic myxoma
• Central odontogenic fibroma
• Calcifying epithelial odontogenic tumor
• Orthokeratinized odontogenic cyst
• Lateral periodontal cyst
• Calcifying odontogenic cyst
• Central hemangioma
• Aneurysmal bone cyst
• Cherubism
• Hyperparathyroidism
• Intraosseous mucoepidermoid carcinoma
• Fibrous dysplasia

Radiolucencies:

Poorly defined or ragged borders

More Likely:

• Periapical granuloma or cyst
• Focal osteoporotic marrow defect

Likely:

• Osteomyelitis
• Bisphosphonate associated osteonecrosis

Less Likely:

• Simple bone cyst
• Metastatic tumors
• Osteoradionecrosis
• Multiple myeloma
• Primary intraosseous carcinomas
• Osteosarcoma
• Chondrosarcoma
• Ewing's sarcoma

Radiolucencies:

Multifocal or Generalized

More Likely:

• Cemento-osseous dysplasia

Likely:

• Nevoid basal cell carcinoma syndrome
• Multiple myeloma

Less Likely:

• Cherubism
• Hyperparathyroidism
• Langerhans cell histiocytosis

Radiopacities:

Well-Demarcated borders

Most Likely:

• Torus or exostosis
• Retained root tip
• Condensing osteitis
• Idiopathic osteosclerosis

Likely:

• Pseudocyst of the maxillary sinus
• Odontoma, compound
• Odontoma, complex
• Cemento-osseous dysplasia
• Soft tissue radiopacity superimposed

Less Likely:

• Intraosseous foreign body
• Osteoma
• Enamel pearl
• Osteoblastoma/osteoid osteoma/cementoblastoma

Radiopacities:

Poor demarcated borders

Likely:

• Cemento-osseous dysplasia
• Condensing osteitis
• Bisphosphonate-associated osteonecrosis
• Sclerosing osteomyelitis
• Fibrous dysplasia

Less Likely:

• Paget's disease of bone
• Proliferative periostitis
• Osteosarcoma
• Chondrosarcoma

Radiopacities:

Multifocal or Generalized

Likely:

• Florid cemento-osseous dysplasia
• Idiopathic osteosclerosis
• Bisphosphonate associated osteonecrosis

Less Likely:

• Paget's disease of bone
• Gardner syndrome
• Polyostotic fibrous dysplasia
• Osteopetrosis

Radiopacities: